Plants have long been a source of nutrition and therapy to man. The medicinal value of these plants lies in some chemical substances that produce a definite physiological action in the human body. This study evaluated the oxytocic potential of methanol extract of Sida acuta on female albino rats in vitro. Oxytocin was used as a standard drug though it is a biochemically synthesized hormone that act on distant hormone receptor to induce contractions. The methanol extract was prepared using cold maceration method. Matured female non pregnant albino rats were used for this study using their uterine smooth muscle tissue. The extracts 667µg/ml, 1334µg/ml and 2668µg/ml was applied respectively to the organ bath containing the uterine tissue and using a digital physiological recorder, the extract was found to induce contraction of the uterine tissue. The extract produced its optimum frequency at 2668µg/ml (57.10%). The extract like oxytocin induce contraction by increasing Ca2+ influx which activates Ca2+ dependent cytosolic protein (calmodulin) to form Ca2+-calmodulin complex.
TABLE OF CONTENTS
3.1 APPARATUS AND EQUIPMENTS
RESULT AND ANALYSIS
DISCUSSION, CONCLUSION AND RECOMMENDATIONS
Iyke, J (2020). Evaluation of Oxytocic Potential of Methanol Extracted sida acuta on Female Albino Rats. Afribary.com: Retrieved August 03, 2020, from https://afribary.com/works/afriby-project-submission-main
Johnson, Iyke. "Evaluation of Oxytocic Potential of Methanol Extracted sida acuta on Female Albino Rats" Afribary.com. Afribary.com, 08 Jul. 2020, https://afribary.com/works/afriby-project-submission-main . Accessed 03 Aug. 2020.
Johnson, Iyke. "Evaluation of Oxytocic Potential of Methanol Extracted sida acuta on Female Albino Rats". Afribary.com, Afribary.com, 08 Jul. 2020. Web. 03 Aug. 2020. < https://afribary.com/works/afriby-project-submission-main >.
Johnson, Iyke. "Evaluation of Oxytocic Potential of Methanol Extracted sida acuta on Female Albino Rats" Afribary.com (2020). Accessed August 03, 2020. https://afribary.com/works/afriby-project-submission-main