Research Papers/Topics in Biochemistry

EFFECT OF SWIMMING TRAINING ON COGNITIVE FUNCTION IN SCOPOLAMINE INDUCED DEMENTIA IN MICE.

ABSTRACTThe present study investigated the effects of a 2-week swimming exercise on scopolamine-induced dementia in a mice model. Thirty-two mice, were randomly divided into four groups (8 rats in each). Group A served as control without exercise and received saline only; Group B served as induced control and receive a single dose of scopolamine (1 mg/kg, i.p.) only on the last day; group C mice were subjected to short-term exercise (swimming) + single dose of scopolamine (1 mg/kg, i.p.) on t...

Evaluation of Nutritional and Anti-nutritional Compositions of Leaves of Gingko biloba (Maiden Hair) Tree Found in Nigeria.

ABSTRACTGinkgo biloba (GB) leaves and extracts have been recognized worldwide for its renowned nutritional and medicinal properties. GB tree is highly grown and used in Asian and South American countries unlike Nigeria. In this study, we examined the nutritional and anti-nutritional compositions of GB leaves (whole dried, and aqueous and ethanol extracts) grown in Nigeria. Association of Official Analytical Chemists (AOAC) method was used to determine the proximate and vitamin compositions wh...

In Vitro Antioxidant Activity and Nitric Oxide Scavenging Activity on Citrullus Lanatus Seeds

Citrullus lanatus (water melon) is a commonly consumed fruit worldwide. The seeds are often thrown away without considering its potential nutritional and medicinal benefits. In this study, a methanol extract of citrullus lanatus seeds was analyzed for the presence of bioactive secondary metabolites and to determine its ability to scavenge 2, 2‐ diphenyl ‐1‐ picrylhydrazyl (DPPH.) radical, superoxide anion radical (O2.‐), and nitric oxide radical (NO.). Quantitative phytochemical a...

Molecular Docking and Structure Based Drug Design

Docking is a structure-based technique which attempts to find the “best” match, between two molecules. Molecular docking can be thought of as a problem of “lock-and-key”, in which one wants to find the correct relative orientation of the “key” which will open up the “lock” (where on the surface of the lock is the key hole, which direction to turn the key after it is inserted, etc.). The explosion of structural informatics, genomics and proteomic plays a major role in leading t...

NUTRITIONAL AND ANTI-NUTRITIONAL CONTENTS OF INGREDIENTS USED IN PREPARING GRANULATED DUMPLING (DAMBU)

ABSTRACTNutritional and antinutritional content of ingredient used in preparing dambu were determined by proximate composition, vitamins, minerals and antinutritional contents analysis. Maize and Moringa flowers were used as the experimental samples and the work was conducted in triplicate which resulted in obtaining the experimental result in mean and standard deviation. Appreciable amount of nutritive composition were obtain in the used maize and Moringa samples. While the antinutritional c...

KIDNEY FUNCTION PARAMETERS F PLASMODIUM PASSAGED MICE TREATED WITH CRUDE METHANOLEXTRACT OF AZADIRACHTA INDICA (NEEM)

ABSTRACT Kidney function parameters were evaluated in plasmodium berghei infected mice treated with crude methanol extracts of Azadirachta indica leaves in this study. A total of  forty (40) male albino mice inoculated with quinine resistant strains of plasmodium berghei were randomized into nine (9) groups of (4) animals each while four additional mice serve as the uninfected control group. Group 1 was treated with tween 80, group 2 treated with 10mg/kg chloroquine while groups 3,4...

Effects of White Grub Extracts on Serum Glucose and Lipid Profile of Alloxan Induced Diabetes in Rats

Diabetes mellitus is a syndrome characterized by chronic hyperglycemia and disturbances of carbohydrate, fat and protein metabolism associated with an absolute or relative deficiency in insulin secretion or insulin action. To investigate the effect of white grub extract on alloxan-induced diabetic rats. Diabetes was induced in rats after 18 hours of fasting intraperitoneally by alloxan (80 mg/kg). A total of 40 rats used, were divided into eight groups (G1- GVIII) of five rats each. GII-G...

Consumption of green tea (Camellia sinensis)

ABSTRACT Consumption of green tea (Camellia sinensis) may provide protection against chronic diseases, including cancer. Green tea polyphenols are believed to be responsible for this cancer preventive effect, and the antioxidant activity of the green tea polyphenols has been implicated as a potential mechanism. This hypothesis has been difficult to study in vivo due to metabolism of these compounds and poor understanding of the redox environment in vivo. Green tea polyphenols can be...

Therapeutic Effect of Methanolic Extract of Telfairia occidentalis Leaves against Ethanol-Induced Oxidative Stress in Wistar Rats

This study sought to investigate the therapeutic effectof methanolic extract of Telfairia occidentalis leavesagainst acute ethanol-induced oxidative stress inWistar rats. Fresh plants of T. occidentalis werepurchased from Oja-Oba Market in Ibadan. Theleaves were dried and extracted using soxhletapparatus and methanol as the solvent. The methanolwas evaporated in a rotary evaporator at 35 oC witha yield of 2.31g representing a percentage yield of9.24%. Twenty adult male Wistar rats were used f...

Antihaemolytic Effect of Ethanolic Leaf Extract of Vernonia amygdalina in Wistar Rats

Antihaemolytic effect of ethanolic leaf extract ofVernonia amygdalina in Wistar rats is the aim of thisstudy. Fresh plants of V. amygdalina were harvestedfrom the Institute of Agricultural Research andTraining, Ibadan. The leaves were carefully removedfrom the stem and washed in running water toremove contaminants. They were air dried at roomtemperature in an open laboratory space for 14 daysand milled into powder. The extraction was doneusing soxhlet apparatus and ethanol as the solvent.Etha...

Preventive and Therapeutic Activities of Methanolic Extract of Talinum triangulare Leaves against Ethanol-Induced Oxidative Stress in Wistar Rats

Preventive and therapeutic activities of methanolicextract of Talinum triangulare leaves againstethanol-induced oxidative stress in wistar rats is theaim of this study. Fresh plants of T. triangulare werepurchased at a local market in Orita-Challenge,Ibadan. The leaves were dried and extracted usingsoxhlet apparatus and methanol as the solvent. Themethanol was evaporated in a rotary evaporator at35 oC with a yield of 2.76 g which represents apercentage yield of 11.04%. Twenty Wistar rats with...

Antioxidant Defense System in a Germinating P.Vulgaris

Phaseolus vulgaris, Common Bean is a herbaceous annual plant grown worldwide for its edible dry seed (known as just "beans") or unripe fruit (green beans) and a member of the legume family Fabaceae.  They are quite popular amongst the natives because of its high protein, minerals and vitamins content (Gentry et al., 1999).The use of a wide range of chemicals to destroy pests and weeds is an important aspect of agricultural practice in both developed and developing countries but there is a wi...

Antioxidant Property of Coconut (Cocos nucifera) Water

ABSTRACTCoconut water is a natural nutritious beverage that contains several biologically active compounds. This study was set up to evaluate the antioxidant potential of coconut water. Twenty five adult male albino rats, used in this work, were grouped into five (A, B, C, D and E), of five rats per group. Groups A, B, C and D were administered orally with 0.5, 1.0, 1.5 and 2.0mg/kg body weight respectively of the coconut water for seven consecutive days. Group E was the control. Giutathione ...

COMPARATIVE ANALYSIS OF HEAVY METALS IN BRASSICA OLERACEA FROM KENYATTA MARKET, NAIROBI AND KAGOCHI, KARATINA

ABSTRACTVegetables has been an integral part of day to day diet for so many people in Kenya. It is used in the form of raw fruits, dried, powdered or cooked vegetables. This is a research that addresses this way of living to act as a precaution towards making the food healthier. It is with a significant concentration in Kenyatta market than Kagochi while chromium’s level was higher in Kagochi compared to Kenyatta market.From the above figures of heavy metals, it was conc...

Alteration in biochemical indices following chronic administration of methanolic extract of Nigeria bee propolis in Wistar rats

Objective: To determine the noxious attribute of methanol extract of Nigeria bee propolis at 300 and 600 mg/kg body weight in rats.Methods: Healthy Wistar rats were indiscriminately assigned into three groups (A-C) of five rats each. The control rats (Group A) were orally given 0.5 mL of dimethyl sulfoxide daily for 21 days while rats in Groups B and C were administered the same 0.5 mL dimethyl sulfoxide containing 300 and 600 mg/kg body weight methanol extract of bee propolis respectivel...

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