Analgesic Effects Of Synedrella Nodiflora (L) Gaertn Whole Plant Extract In Streptozotocin- Induced Diabetic Neuropathy In Rats.

ABSTRACT

Background: The ethanolic extract of Synedrella nodiflora has demonstrated analgesic activity in acute and chemotherapy-induced neuropathic pain in rodents. The present study evaluates the analgesic effect in hyperalgesia and allodynia associated with streptozotocin–induced diabetic neuropathy in rats and also elucidates the antioxidant activity of the extract.

Method: Diabetic neuropathy was induced by intraperitoneal injection with 55 mg/kg freshly prepared streptozotocin (STZ) dissolved in 0.1 mol/l citrate buffer (pH 4.4). At the end of the first week after STZ injection, blood sugar measurements were taken for diagnosing diabetes. Rats that became neuropathic after 3 weeks of successful diabetes induction were pretreated with SNE (100, 300, 1000 mg/kg, p.o), pregabalin (PGB) (10, 30,100 mg/kg, p.o) and vehicle (0.5ml normal saline) respectively. Pain assessment tests; hot plate, cold water and the paw pressure analgesimeter were used to measure the pain threshold on alternate days. Blood serum was collected for biochemical analysis and assayed for malondialdehyde concentration and superoxide dismutase activity. Selected organs of interest were isolated and examined for any pathological alterations using the haematoxylin and eosin method

Results: Synedrella nodiflora (SNE) increased reaction latency to thermal and mechanical hyperalgesia dose- dependently and significantly (p

Subscribe to access this work and thousands more
Overall Rating

0

5 Star
(0)
4 Star
(0)
3 Star
(0)
2 Star
(0)
1 Star
(0)
APA

–BOAHEN, K (2021). Analgesic Effects Of Synedrella Nodiflora (L) Gaertn Whole Plant Extract In Streptozotocin- Induced Diabetic Neuropathy In Rats.. Afribary. Retrieved from https://afribary.com/works/analgesic-effects-of-synedrella-nodiflora-l-gaertn-whole-plant-extract-in-streptozotocin-induced-diabetic-neuropathy-in-rats

MLA 8th

–BOAHEN, KWABENA "Analgesic Effects Of Synedrella Nodiflora (L) Gaertn Whole Plant Extract In Streptozotocin- Induced Diabetic Neuropathy In Rats." Afribary. Afribary, 09 Apr. 2021, https://afribary.com/works/analgesic-effects-of-synedrella-nodiflora-l-gaertn-whole-plant-extract-in-streptozotocin-induced-diabetic-neuropathy-in-rats. Accessed 24 Jul. 2024.

MLA7

–BOAHEN, KWABENA . "Analgesic Effects Of Synedrella Nodiflora (L) Gaertn Whole Plant Extract In Streptozotocin- Induced Diabetic Neuropathy In Rats.". Afribary, Afribary, 09 Apr. 2021. Web. 24 Jul. 2024. < https://afribary.com/works/analgesic-effects-of-synedrella-nodiflora-l-gaertn-whole-plant-extract-in-streptozotocin-induced-diabetic-neuropathy-in-rats >.

Chicago

–BOAHEN, KWABENA . "Analgesic Effects Of Synedrella Nodiflora (L) Gaertn Whole Plant Extract In Streptozotocin- Induced Diabetic Neuropathy In Rats." Afribary (2021). Accessed July 24, 2024. https://afribary.com/works/analgesic-effects-of-synedrella-nodiflora-l-gaertn-whole-plant-extract-in-streptozotocin-induced-diabetic-neuropathy-in-rats