Research Papers/Topics in Pharmacology

Protective Role of Aqueous Leaf Extract of Vernonia Amygdalina Del. (Asteraceae) and Ocimum Gratissimum Linn (Lamiaceae) in Cyclophosphamide Induced Urotoxicity and Myelosuppression

ABSTRACT  Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. In the present study, the protective potential of Vernonia amygdalina and Ocimum gratissimum aqueous leaf extracts in CP-induced urotoxicity and myelosupression were evaluated using biochemical and histopathological approaches. Sodium -2-macarptoethane sulfonate (MESNA) was used as a...

Evaluation of the Subacute and Delayed Toxicity of Artemether-Lumefantrine Combination in Rats

ABSTRACT  Despite the reported rapid increase in demand for artemisinin and its derivatives, there is little independent collaboration of the toxicity patterns of artemether-lumefantrine combination besides those documented by the manufacturer in its application for approval. It is however, pertinent to conduct an independent evaluation of the subacute and delayed toxicity of artemether-lumefantrine combination (ALC). In this study, rats in groups I-VI were administered varying concentration...

Evaluation of the Immunomodulatory Activities of the Aqueous Extract and the BetaD-Glucan-Rich Polysaccharide Fraction of Pleurotustuberregium(Pleurotaceae)

ABSTRACT Mushroom cuisines are global delicacies and have been used for decades, not only as food, but mostly for the health benefits which are claimed or scientifically proven. The present study explored the immunomodulatory activities of the hot aqueous extract of a local oyster mushroom, Pleurotustuberregium (Fr.) Singer (Pleurotaceae) (PT) and its β–D-Glucan-Rich Polysaccharide fraction (BGP).The effects of the aqueous extract (PT) and the β–D-Glucan-Rich Polysaccharide fraction (B...

Effects of Heavy Metals on the Air Pollution Tolerance Indices ( Apti ) of Five Medicinal Plants Growing Within Quarry Site in Ishi-Agu, Ebonyi State, Nigeria.

ABSTRACT Effects of heavy metals on the Air Pollution Tolerance Indices (APTI) of five medicinal plants growing within quarry site in Ishi-Agu, Ebonyi State, Nigeria were studied. Following laboratory analysis of the leaves of the plants for metal load and four biochemical parameters of APTI computation. The metal load was determined by the Atomic Absorption spectrophotometric method, while the ascorbic acid was determined by the titremetric method, leaf extract pH by the electro-chemical tec...

Antihyperlipidemic and Antioxidant Effects of Phaseolus Vulgaris Linn in Wistar Rats

ABSTRACT In this study, the antihyperlipidemic and antioxidants activities of the extract and fractions of Phaseolus vulgaris L. were evaluated. The crude extract (PVE) of dried pulverized plant material was obtained by maceration in methylene chloride/methanol (1:1) while the solvent fractions were obtained by successive solvent-solvent partition in separating funnel between the crude extract suspended in aqueous medium and solvents of increasing polarity to obtain the n-hexane fraction (PVH...

Antioxidant and Hepatoprotective Studies of Annonasenegalensispers. (Annonaceae) Stem Bark.

Abstract The study was carried out to determine pharmacognostic standards, phytochemical constituents, evaluate the antioxidant and hepatoprotective activities of the extract and fractions of Annona senegalensis Pers. (Annonaceae) by employing both the in vitro and in vivo experimental models. The acute toxicity tests result showed the drug is safe at 5000mg/kg doses. The effect of DPPH free radical scavenging, ABTS radical scavenging, Hydroxyl radical scavenging, Hydrogen peroxide scavenging...

Pharmacological Evaluation and Characterization of the Antiulcer Constituents of Stem Bark Extract of Bridelia Ferruginous Benth (Euphorbiaceous)

ABSTRACT Peptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. The search for an ideal antiulcer drug continues and has also been extended to medicinal plants. Bridelia ferruginea Benth (Euphorbiaceae) is a plant used in traditional medical practice in South West Nigeria. This study was aimed at evaluating the antiulcer activity and mechanisms of the extract of the stem bark and to isolate the bioactive constituents responsible for the antiulcer activity. Metha...

Pharmacological Assessment of Lupinus Arboreus Sims (Fabaceae) Methanol Extract and Three Active Constituents for Antinociceptive and Anti-Inflammatory Effects

ABSTRACT The methanol extract and chemical constituents of Lupinus arboreus leaf were investigated for antinociceptive and anti-inflammatory activities. The study was by experimental design. the extract was partitioned to yield hexane, ethylacetate, and methanol fractions. Phytochemical tests were done on the extract and fractions. Acute toxicity test (LD50) was carried out on crude methanol leaf extract (CME). Extract hexane fraction (HEF), ethylacetate fraction (EAF) and methanol fraction (...

Evaluation of the Immunomodulatory Activities of the Aqueous Extract and the Beta–D-Glucan-Rich Polysaccharide Fraction of Pleurotustuberregium(Pleurotaceae)

ABSTRACT Mushroom cuisines are global delicacies and have been used for decades, not only as food, but mostly for the health benefits which are claimed or scientifically proven. The present study explored the immunomodulatoryactivites of the hot aqueous extract of a local oyster mushroom, Pleurotustuberregium (Fr.) Singer (Pleurotaceae) (PT) and its β–D-Glucan-Rich Polysaccharide fraction (BGP).The effects of the aqueous extract (PT) and the β–D-Glucan-Rich Polysaccharide fraction (BGP)...

2_Ajibo et al analgesic cpds

The Antioxidant Analgesic activity of some Natural plants in Comparison to Acetaminophen 

Pharmacological Effects of Methanol Extract of Garcinia Kola (Heckel) Seed on the Reproductive Profiles of Some Male Experimental Animals

ABSTRACT Garcinia kola is commonly consumed in Nigeria in social ceremonies and for leisure purposes. It is speculated to enhance sexual performance in males. The effects of methanolic extract of Garcinia kola seed on the male reproductive profiles of rats were determined at oral doses of 125, 250 and 500 mg/kg for 20 and 60 days respectively. The animals were administered the extract orally for either 20 or 60 days after which analysis of the parameters were carried out using known standard...

PHARMACOGNOSTIC INVESTIGATION, ISOLATION, CHARACTERIZATION AND CONFIRMATION OF THE STRUCTURE OF PHENACETINE EXTRACTED FROM THE DRIED POWDERED LEAVES OF TRADITIONAL MEDICINAL PLANT ALLOPHYLUS

Abstract Pharmacognostic investigation involving organoleptic evaluation, fluorescent analysis, phytochemical screening and mineral analysis was carried out on the dried powdered leaves of Allophylus africanus used for treating pain, headaches, common cold, Fever and as antibiotics in Eastern Province of Sierra Leone. The powdered leaves were light brown in colour with woody odour, bitter taste and gave significant fluorescent derivatives with the reagents 1M NaOH (aq), 1M NaOH(alc.), Ammonia...

Evaluation Of Efficacy Of Albendazole 2.5% Drench Formulation And Possible Multi-Drug Resistance For Treatment Of Gastrointestinal Nematodes In Naturally Infected Sheep

Part of this work has been accepted for publication as paper entitled: 1. Nuha Abu Elabbas Dia Alnaeim, Hisham Ismail Seri, Siham Elias Suliman, Omar Ibrahim Omar Ali (2019). Evaluation of Efficacy of four anthelmintics and possible multiple-Drug Resistance in Sheep in Sudan. SUST Journal of Agricultural and Veterinary Sciences, 20(1): (Accepted)

Serum Profiles Of Pro-Inflammatory Cytokines And Some Other Biomarkers Of Inflammation In Nigerian Tuberculosis Patients Undergoing Standard Chemotherapy At Enugu.

Introduction:Tuberculosis (TB) is a communicable disease that has afflicted man for centuries. It is one of the commonest causes of death from infectious diseases in the world. Nigeria is ranked among the 22 countries with the highest TB burden in the world. The discovery of host or pathogen specific biomarkers of TB for diagnosis, treatment, and prognosis has of recent become top research priority globally. The pathogenesis of TB involves cell-mediated immune response against Mycobacterium t...

Pharmacological Assessment Of Lupinus Arboreus Sims (Fabaceae) Methanol Extract And Three Active Constituents For Antinociceptive And Anti-Inflammatory Effects

ABSTRACT The methanol extract and chemical constituents of Lupinus arboreus leaf were investigated for antinociceptive and anti-inflammatory activities. The study was by experimental design. the extract was partitioned to yield hexane, ethylacetate, and methanol fractions. Phytochemical tests were done on the extract and fractions. Acute toxicity test (LD50) was carried out on crude methanol leaf extract (CME). Extract hexane fraction (HEF), ethylacetate fraction (EAF) and methanol fraction ...


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