Research Papers/Topics in Pharmacology

Evaluation Of Efficacy Of Albendazole 2.5% Drench Formulation And Possible Multi-Drug Resistance For Treatment Of Gastrointestinal Nematodes In Naturally Infected Sheep

Part of this work has been accepted for publication as paper entitled: 1. Nuha Abu Elabbas Dia Alnaeim, Hisham Ismail Seri, Siham Elias Suliman, Omar Ibrahim Omar Ali (2019). Evaluation of Efficacy of four anthelmintics and possible multiple-Drug Resistance in Sheep in Sudan. SUST Journal of Agricultural and Veterinary Sciences, 20(1): (Accepted)

Microbial Connections: The Rise of Antibiotic Resistance

Talk OutlineIntroduction to antibiotic resistanceThe antibiotic resistance crisisNext steps

Mechanisms of General Anesthesia

IntroductionThe branch of pharmacology that relates drug concentra￾tion to biologic effect is known as pharmacodynamics. Major goals of this area of study are determining the proper dose to administer to elicit the desired effect while avoiding toxicity. Although pharmacokinetics can be used to deter￾mine dosing requirements necessary to maintain a particu￾lar drug concentration, it is the relationship between drug concentration and effect that ultimately decides appropri￾ate dosi...

Serum Profiles Of Pro-Inflammatory Cytokines And Some Other Biomarkers Of Inflammation In Nigerian Tuberculosis Patients Undergoing Standard Chemotherapy At Enugu.

Introduction: Tuberculosis (TB) is a communicable disease that has afflicted man for centuries. It is one of the commonest causes of death from infectious diseases in the world. Nigeria is ranked among the 22 countries with the highest TB burden in the world. The discovery of host or pathogen specific biomarkers of TB for diagnosis, treatment, and prognosis has of recent become top research priority globally. The pathogenesis of TB involves cell-mediated immune response against Mycobact...

Pharmacological Assessment Of Lupinus Arboreus Sims (Fabaceae) Methanol Extract And Three Active Constituents For Antinociceptive And Anti-Inflammatory Effects

ABSTRACTThe methanol extract and chemical constituents of Lupinus arboreus leaf were investigatedfor antinociceptive and anti-inflammatory activities. The study was by experimental design.the extract was partitioned to yield hexane, ethylacetate, and methanol fractions.Phytochemical tests were done on the extract and fractions. Acute toxicity test (LD50) wascarried out on crude methanol leaf extract (CME). Extract hexane fraction (HEF),ethylacetate fraction (EAF) and methanol fraction ...

Contribution of Indigenous Health Care Givers to -The Herbal Management of Febrile Illnesses in Rivers State, South-South, Nigeria

Introduction Malaria remains a major public health concern, especially in Africa, despite several years of research and billions of dollars spent on the development of drugs for the treatment of the disease. It is estimated that about 300 to 500 million cases of malaria occur globally every year, out of which 90% of the cases occur In Africa. It is also estimated that malaria is responsible for 1-2 million deaths annually in Africa (Toklohuimnnot, 2000). For over fifty years, the mai...

Phytosterols from Spondias mombin Linn with Antimycobacterial Activities

ABSTRACT The growing problems of tuberculosis have led to the search for new anti-Mtb agents from higher plants. The stem bark of Spondias mombin was evaluated for its in vitro activity against Mycobacterium tuberculosis (H37Rv strain). Bioassay-guided fractionation of the methanol extract was carried out by Vacuum Liquid Chromatography (VLC) on Silica gel (230-400 mesh) and purification was done using HPLC and TLC. In vitro antimycobacterial susceptibility was performed by a fluor...

Studies Of The Excretion Of Aluminium By The Kidney And The Toxic Effects Of The Element On Dna

ABSTRACTTHESIS TITLE: Studies of the excretion of aluminium bythe kidney and the toxic effects of the element on DNA.CANDIDATE: Felix Salvador Emilio Monteagudo, c/oDepartment of Pharmacology, University of Cape Town, CapeTown. February, 1991.Aluminium is an element of increasing clinicalimportance. It not only has uses as a medicinal substancebut also in recent years it has been shown to be thecause of considerable toxicity, particularly in thesetting of chronic renal failure. Disea...

Evaluation Of The Immunomodulatory Activity Of Hoslundia Opposita Vahl (Lamiaceae) Leaf Extract

ABSTRACTThe immunomodulatory properties of methanol extract and fractions of Hoslundia opposita leafon Delayed-Type Hypersensitivity (DTH), primary and secondary humoral response and in vivoleucocyte mobilization were evaluated. Acute toxicity test of crude extract and phytochemistrystudy was carried out. The methanol extract (ME) at 200, 400 and 800 mg/kg body weightproduced significant (P

Studies On The Anti-Ulcer Activities Of The Fruit Extract And Fractions Of Cucumis Metuliferus (Cucurbitaceae)

ABSTRACTThe anti-ulcer and other gastrointestinal effects of the methanol extract and fractions ofCucumis metuliferus were investigated in rats and mice. Ethyl acetate (EAFCM), butanol(BFCM) and water (WFCM) fractions obtained from the methanol extract of Cucumismetuliferus (MECM) were screened for anti-ulcer activity. The anti-ulcer effect wasinvestigated on gastric ulcers induced by absolute ethanol, hypothermic-restraint stress andindomethacin in rats. The median lethal dose (LD50)...

Studies On Anthelmintic Activity Of Tithonia Diversifolia In Mbinga District, Tanzania

ABSTRACT Gastrointestinal nematode parasitism is a global problem in both sub-tropical and tropical countries. Due to frequent administration of chemical anthelmintics the gastrointestinal nematodes have developed resistance hence giving rise to the search of alternative anthelmintics. This study was carried out to evaluate anthelmintic effects of Tithonia diversifolia in Mbinga district, Ruvuma region, Tanzania. The study specifically dealt with evaluation of the efficacy of T. diversi...

Pharmacological Evaluation And Characterization Of The Antiulcer Constituents Of Stem Bark Extract Of Bridelia Ferruginea Benth (Euphorbiaceae)

ABSTRACTPeptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. The searchfor an ideal antiulcer drug continues and has also been extended to medicinal plants. Brideliaferruginea Benth (Euphorbiaceae) is a plant used in traditional medical practice in South WestNigeria. This study was aimed at evaluating the antiulcer activity and mechanisms of the extractof the stem bark and to isolate the bioactive constituents responsible for the antiulcer activity.Metha...

Effects Of Heavy Metals On The Air Pollution Tolerance Indices ( Apti ) Of Five Medicinal Plants Growing Within Quarry Site In Ishi-Agu, Ebonyi State, Nigeria.

ABSTRACT Effects of heavy metals on the Air Pollution Tolerance Indices (APTI) of five medicinal plants growing within quarry site in Ishi-Agu, Ebonyi State, Nigeria were studied. Following laboratory analysis of the leaves of the plants for metal load and four biochemical parameters of APTI computation. The metal load was determined by the Atomic Absorption spectrophotometric method, while the ascorbic acid was determined by the titremetric method, leaf extract pH by the electro-chemi...

Hepatoxicity And Hematological Effects Of Combination First Line Antituberculosis Drugs In Healthy Sprague-Dawley Albino Rats

ABSTRACTThe commonly used antituberculosis (anti-TB) drugs, pyrazinamide (PZA), isoniazid (INH), ethambutol (EMB), and rifampicin (RMP) were administered to albino rats for the purpose of investigating the toxic consequences of combination therapies on the hematological and hepatic systems. The drugs were evaluated by simulating the normal clinical dosage. A 24-week oral administration studies of standard therapy with anti-TB drugs in albino rats without disease were carried out. The do...


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