Anti-Hyperglycaemic And Anti-Oxidant Effect Of Synedrella Nodiflora (L) Gaertn In Streptozotocin-Induced Diabetes In Rats..

ABSTRACT Background: Synedrella nodiflora is a common weed in Ghana that is boiled to treat epilepsy and threatened abortion. The ethanolic whole plant extract has been demonstrated to have antiinflammatory, antioxidant, hypoglycemic, anticonvulsant, sedative, antidepressant and antipsychotic effects in murine models. The study presents the anti-oxidant and antihyperglycaemic effects of the ethanolic extract of the whole plant extract of Synedrella nodiflora (SNE) on a diabetic rat model. Method: Diabetes was induced using an intraperitoneal injection of streptozotocin (STZ) (55 mg/kg). SNE (100, 300, 1000 mg/kg, p.o) and insulin (0.1, 0.3, 1.0 IU/kg, s.c.) were administered for 8 weeks. Bodyweight and fasting blood sugar were measured twice weekly. Serum biochemistry, haematological indices, organ histopathology, MDA and SOD assay were done. Results: SNE induced a significant decrease (P< 0.05) in hyperglycaemia, with a corresponding increase in weight of the rats. The extract also reduced significantly the liver enzymes AST, ALT, ALP and increased albumin levels compared to the vehicle group (P< 0.01). SOD and MDA tests both showed significant increase (P< 0.05) and decrease (P< 0.01) respectively for SNE high dose of 1000 mg/kg, indicating antioxidant activity. Haematological indices showed a decrease in RBC and an increase in eosinophil count in the vehicle group (P< 0.05). Conclusion: The ethanolic extract of the whole plant of Synedrella nodiflora possess antioxidant and anti-hyperglycaemic effects on rat model of diabetes.