Antidiabetic And Wound Healing Properties Of Selected Kenyan Tea Cultivars

ABSTRACT

Diabetes mellitus is a metabolic disorder of multiple etiology, characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. It is associated with significant morbidity and mortality due to cardiovascular complications as a result of imbalance in lipid metabolism. Diabetic foot ulcers (DFUs) are estimated to occur in 15% of all patients with diabetes and precede 84% of all diabetes-related lower leg amputations. Tea is rich in bioactive molecules that may play a role in modulating carbohydrate metabolism and wound healing. The study sought to determine if tea can prevent or reverse metabolic disturbances induced by diabetes, including occurrence of diabetic wounds. Green and black teas were processed from four different cultivars and assayed for their total monomeric anthocyanin content, total polyphenols content, catechin profiles and theaflavin profiles. Teas rich in anthocyanins, epigallocatechin gallate (EGCG), theaflavins (TF) and total polyphenols were chosen for assay in an animal model. An alloxan induced diabetic mouse model was used to study the anti diabetic potential of processed tea. Hyperglycaemia resulting from alloxan administration caused a significant (p