In this study, we evaluated the effect of the total phenol extract of Zanthoxylum
zanthoxyloides leaves on oral glucose tolerance, lipid profile, liver function, oxidative stress
parameters, and pancreas histopathology in diabetic rats. Diabetes was induced in rats by
administration of alloxan monohydrate in a dose of 130 mg/kg b/w. Total phenol content of
Z. zanthoxyloides leaves was administered to rats at 100, 200 and 400 mg/kg b/w daily for 15
days. Blood glucose was measured by glucose oxidase method; lipid profile, liver function
and oxidative stress parameters were monitored by standard methods and pancreatic
histopathology evaluated microscopically. The results showed an increase in blood glucose
level of the rats after administration of alloxan monohydrate. Two weeks after treatment with
Z. zanthoxyloides, a significant (p<0.05) reduction in blood glucose was recorded within the
treatment groups compared to the untreated control group. Total cholesterol and low density
lipoproteins (LDL) were significantly (p<0.05) lower in the treated groups, with lowest
values recorded in the group treated with the highest concentration of the extract. The result
also showed that aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine
aminotransferase (ALT) activities were lowest on treatment with highest concentration of the
phenol extract, while glutathione (GSH) and vitamin C levels were increased in the treated
groups compared to the diabetic and untreated groups. The result of the pancreatic
histopathology further supported the protective effect of Z. zanthoxyloides phenol extract
towards diabetic damage. From these results, we suggested that total phenolics of Z.
zanthoxyloides may be effective in controlling blood glucose level in diabetics, and in
protecting pancreatic tissues from diabetic damage.
Edu, F (2021). Antidiabetic Properties of Total Phenol Content of Zanthoxylum zanthoxyloides Leaves on Albino Rats. Afribary.com: Retrieved April 20, 2021, from https://afribary.com/works/antidiabetic-properties-of-total-phenol-content-of-zanthoxylum-zanthoxyloides-leaves-on-albino-rats
Frontiers, Edu. "Antidiabetic Properties of Total Phenol Content of Zanthoxylum zanthoxyloides Leaves on Albino Rats" Afribary.com. Afribary.com, 08 Apr. 2021, https://afribary.com/works/antidiabetic-properties-of-total-phenol-content-of-zanthoxylum-zanthoxyloides-leaves-on-albino-rats . Accessed 20 Apr. 2021.
Frontiers, Edu. "Antidiabetic Properties of Total Phenol Content of Zanthoxylum zanthoxyloides Leaves on Albino Rats". Afribary.com, Afribary.com, 08 Apr. 2021. Web. 20 Apr. 2021. < https://afribary.com/works/antidiabetic-properties-of-total-phenol-content-of-zanthoxylum-zanthoxyloides-leaves-on-albino-rats >.
Frontiers, Edu. "Antidiabetic Properties of Total Phenol Content of Zanthoxylum zanthoxyloides Leaves on Albino Rats" Afribary.com (2021). Accessed April 20, 2021. https://afribary.com/works/antidiabetic-properties-of-total-phenol-content-of-zanthoxylum-zanthoxyloides-leaves-on-albino-rats