Cancer is among the leading causes of morbidity and mortality worldwide and accounts for up to 28,000 deaths annually in Kenya. Globally, approximately 13% of all deaths annually are attributed to cancer. Surgery, radiation and chemotherapy are the current treatment techniques for cancer; however, these methods are expensive, have high failure rates and have been associated with detrimental side effects. Plants derived products could be good candidates in alleviating challenges being experienced with current methods. This study aimed at evaluating the photochemistry, antiproliferative potential, safety and probable mechanism of action of Albizia gummifera, Senna didymobotrya, and Rhamnus staddo extracts. Preliminary phytochemical screening was done as per standard procedures. The common 3- (4, 5- dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium (MTT) dye was used in the determination of the antiproliferative activity of the extracts. Extracts induction of VEGF (angiogenesis) and p53 (apoptosis) genes’ expression was evaluated using Real Time Polymerase Chain Reaction with GAPDH as the endogenous control. Acute oral and sub-acute toxicity was evaluated in female Albino Swiss mice.
MBUGUA, R (2021). Antiproliferative Activities, Gene Expression Profiles And Toxicity Of Selected Medicinal Plants Against Cancerous And Normal Cells. Afribary. Retrieved from https://afribary.com/works/antiproliferative-activities-gene-expression-profiles-and-toxicity-of-selected-medicinal-plants-against-cancerous-and-normal-cells
MBUGUA, REGINA "Antiproliferative Activities, Gene Expression Profiles And Toxicity Of Selected Medicinal Plants Against Cancerous And Normal Cells" Afribary. Afribary, 05 Jun. 2021, https://afribary.com/works/antiproliferative-activities-gene-expression-profiles-and-toxicity-of-selected-medicinal-plants-against-cancerous-and-normal-cells. Accessed 18 Apr. 2024.
MBUGUA, REGINA . "Antiproliferative Activities, Gene Expression Profiles And Toxicity Of Selected Medicinal Plants Against Cancerous And Normal Cells". Afribary, Afribary, 05 Jun. 2021. Web. 18 Apr. 2024. < https://afribary.com/works/antiproliferative-activities-gene-expression-profiles-and-toxicity-of-selected-medicinal-plants-against-cancerous-and-normal-cells >.
MBUGUA, REGINA . "Antiproliferative Activities, Gene Expression Profiles And Toxicity Of Selected Medicinal Plants Against Cancerous And Normal Cells" Afribary (2021). Accessed April 18, 2024. https://afribary.com/works/antiproliferative-activities-gene-expression-profiles-and-toxicity-of-selected-medicinal-plants-against-cancerous-and-normal-cells