ABSTRACT
Malaria is the main cause of paediatric morbidity and mortality in holoendemic areas. The populations in these areas have similar transmission intensity and infection rates of Plasmodium falciparum malaria but present different malaria outcomes. The cause of the different clinical outcomes is poorly understood. Pf. has exerted selective pressure on the human genome leading to genetic variability in the host’s immune response genes mediating protection and susceptibility to Pf. malaria. Natural Cytotoxicity Triggering Receptor 3 directly interacts with ligands on parasitized Red Blood Cells activating natural killer cells to carry out cell-mediated cytotoxicity of Pf. pRBCs. However, the contribution of NCR3 promoter polymorphisms in conditioning malaria disease outcomes such as acquisition of parasitaemia, severe malaria anaemia (Hb
ODHIAMBO, O (2021). Association Between Ncr3 Promoter Polymorphisms With Plasmodium Falciparum Malaria Outcomes In Paediatric Population (Aged Below 3 Years) In Siaya County In Western Kenya. Afribary. Retrieved from https://afribary.com/works/association-between-ncr3-promoter-polymorphisms-with-plasmodium-falciparum-malaria-outcomes-in-paediatric-population-aged-below-3-years-in-siaya-county-in-western-kenya
ODHIAMBO, ONYANGO "Association Between Ncr3 Promoter Polymorphisms With Plasmodium Falciparum Malaria Outcomes In Paediatric Population (Aged Below 3 Years) In Siaya County In Western Kenya" Afribary. Afribary, 05 May. 2021, https://afribary.com/works/association-between-ncr3-promoter-polymorphisms-with-plasmodium-falciparum-malaria-outcomes-in-paediatric-population-aged-below-3-years-in-siaya-county-in-western-kenya. Accessed 28 Apr. 2024.
ODHIAMBO, ONYANGO . "Association Between Ncr3 Promoter Polymorphisms With Plasmodium Falciparum Malaria Outcomes In Paediatric Population (Aged Below 3 Years) In Siaya County In Western Kenya". Afribary, Afribary, 05 May. 2021. Web. 28 Apr. 2024. < https://afribary.com/works/association-between-ncr3-promoter-polymorphisms-with-plasmodium-falciparum-malaria-outcomes-in-paediatric-population-aged-below-3-years-in-siaya-county-in-western-kenya >.
ODHIAMBO, ONYANGO . "Association Between Ncr3 Promoter Polymorphisms With Plasmodium Falciparum Malaria Outcomes In Paediatric Population (Aged Below 3 Years) In Siaya County In Western Kenya" Afribary (2021). Accessed April 28, 2024. https://afribary.com/works/association-between-ncr3-promoter-polymorphisms-with-plasmodium-falciparum-malaria-outcomes-in-paediatric-population-aged-below-3-years-in-siaya-county-in-western-kenya