Effects Of Plasmodium Falciparum Infection On Monocyte And Neutrophil Function: A Basis For Increased Destruction Of Unparasitized Erythrocytes

Abstract It has become certain that part o f the haemolytic component o f the anaemia of Plasmodium falciparum malaria results from increased removal o f unparasitized red blood cells. There have been several reports o f associations between positive Coom bs’ DAT and anaemia, and also of observations o f unparasitized erythrocytes in monocytes o f patients with P. falciparum infections. Perturbations in cytokine balance have also been blamed for reduced red cell survival as well as for defective erythropoiesis. This study sought to ascertain to what extent increase in monocyte and neutrophil function and the general inflammatory response to P. falciparum infections contribute to the anaemia of malaria. Neutrophil phagocytic activity, monocytes surface expression of HLA-DR and FcyRIII, and plasma levels o f IL-10, TNF-a, IL8, neopterin, M IP -la and M IP-ip were compared among groups o f children with sesvere P. falciparum malaria anaemia (SA), others with other forms o f malaria (cerebral, CM or uncomplicated, UM) and healthy or asymptomatic controls (AC). Phagocytic activity was measured as ability o f neutrophils to take up fluorescent latex particles. All groups o f children with symptomatic malaria showed higher neutrophil phagocytic activity than the control group (p

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APA

AWANDARE, G (2021). Effects Of Plasmodium Falciparum Infection On Monocyte And Neutrophil Function: A Basis For Increased Destruction Of Unparasitized Erythrocytes. Afribary. Retrieved from https://afribary.com/works/effects-of-plasmodium-falciparum-infection-on-monocyte-and-neutrophil-function-a-basis-for-increased-destruction-of-unparasitized-erythrocytes

MLA 8th

AWANDARE, GORDON "Effects Of Plasmodium Falciparum Infection On Monocyte And Neutrophil Function: A Basis For Increased Destruction Of Unparasitized Erythrocytes" Afribary. Afribary, 06 Apr. 2021, https://afribary.com/works/effects-of-plasmodium-falciparum-infection-on-monocyte-and-neutrophil-function-a-basis-for-increased-destruction-of-unparasitized-erythrocytes. Accessed 17 Jul. 2024.

MLA7

AWANDARE, GORDON . "Effects Of Plasmodium Falciparum Infection On Monocyte And Neutrophil Function: A Basis For Increased Destruction Of Unparasitized Erythrocytes". Afribary, Afribary, 06 Apr. 2021. Web. 17 Jul. 2024. < https://afribary.com/works/effects-of-plasmodium-falciparum-infection-on-monocyte-and-neutrophil-function-a-basis-for-increased-destruction-of-unparasitized-erythrocytes >.

Chicago

AWANDARE, GORDON . "Effects Of Plasmodium Falciparum Infection On Monocyte And Neutrophil Function: A Basis For Increased Destruction Of Unparasitized Erythrocytes" Afribary (2021). Accessed July 17, 2024. https://afribary.com/works/effects-of-plasmodium-falciparum-infection-on-monocyte-and-neutrophil-function-a-basis-for-increased-destruction-of-unparasitized-erythrocytes