ABSTRACT
Terminalia superba Engl. & Diels (Combretaceae), is a member of the genus Terminalia that
comprises around 100 species distributed in tropical regions of the world. In Africa it is found
along the coast of west and central Africa. It has different uses in traditional medicine such as
antimalarial, anti-diabetic, anti-fungal, and anti-hypertensive in the areas where it is found.
Most of these uses are yet to be scientifically investigated. The powdered stem bark of
Terminalia superba was extracted by maceration using methanol. The crude extract was
chromatographically fractionated using n-hexane, ethyl acetate, and methanol. Phytochemical
analysis was conducted on the crude methanol extract, n-hexane, methanol, and ethyl acetate
fractions using standard procedures. The LD50 of the crude methanol extract was determined
using Lorke’s method. The phytochemical analysis showed the presence of alkaloids,
saponins, glycosides, flavonoids, tannins, terpenoids, resins and reducing sugars. The crude
extract, the methanol and ethyl acetate fractions were investigated for anti-ulcer activity using
the ethanol, stress, and aspirin induction models. The parameters evaluated were ulcer index
and percentage protective index. The data was statistically analysed. There was significant
difference (p < 0.05) between the group treated with the crude extract and the control group.
The microscopy showed the presence features characteristic of a bark. The anti-ulcer
screening showed that the methanol extract of Terminalia superba possesses antiulcer
property and its use in traditional medicine for treatment of stomach ulcer is justified.
ONYEGBULAM, C (2021). Evaluation Of Anti-Ulcer Properties Of Methanol Extract Of Terminalia Superba Engl. & Diels (Combretaceae) Stem Bark. Afribary. Retrieved from https://afribary.com/works/evaluation-of-anti-ulcer-properties-of-methanol-extract-of-terminalia-superba-engl-diels-combretaceae-stem-bark
ONYEGBULAM, CHUKUMA "Evaluation Of Anti-Ulcer Properties Of Methanol Extract Of Terminalia Superba Engl. & Diels (Combretaceae) Stem Bark" Afribary. Afribary, 14 May. 2021, https://afribary.com/works/evaluation-of-anti-ulcer-properties-of-methanol-extract-of-terminalia-superba-engl-diels-combretaceae-stem-bark. Accessed 22 Dec. 2024.
ONYEGBULAM, CHUKUMA . "Evaluation Of Anti-Ulcer Properties Of Methanol Extract Of Terminalia Superba Engl. & Diels (Combretaceae) Stem Bark". Afribary, Afribary, 14 May. 2021. Web. 22 Dec. 2024. < https://afribary.com/works/evaluation-of-anti-ulcer-properties-of-methanol-extract-of-terminalia-superba-engl-diels-combretaceae-stem-bark >.
ONYEGBULAM, CHUKUMA . "Evaluation Of Anti-Ulcer Properties Of Methanol Extract Of Terminalia Superba Engl. & Diels (Combretaceae) Stem Bark" Afribary (2021). Accessed December 22, 2024. https://afribary.com/works/evaluation-of-anti-ulcer-properties-of-methanol-extract-of-terminalia-superba-engl-diels-combretaceae-stem-bark