ABSTRACT
In the tropics, malaria has become the most alarming public health problem, hence the need
for a mosquito repellent, a personal protection against the vector. The concern about the
deleterious effects associated with synthetic chemicals like N, N-diethy-3-methylbenzamide
(DEET) has elicited the interest to explore plant materials as source of natural repellent for
mosquito control. The aim of this study was to formulate and evaluate herbal mosquito
repellent cream based on solid lipid microparticles (SLM). To determine the mosquito
repellent activity of Ocimum gratissimum ethanol extract and eucalyptus oil, SLM-based
creams containing various concentrations of Ocimum gratissimum and eucalyptus oil were
formulated and tested against three species of mosquito viz; Anopheles gambaiae, Aedes
aegypti and Culex quinquefasciatus. The SLM-based cream formulations were characterized
for their physicochemical (colour, texture, odour and stability) and rheological properties
(spreadability, oclusivity), particle size and pH. It was found that the repellent effect of the
creams was dependent on the concentration of the repellents. Also, the creams with Ocimum
gratissimum ethanol extract provided protection for up to two hours against Anopheles
gambaiae and Culex quinquefasciatus, while the creams with eucalyptus oil provided
protection for up to two hours against Anopheles gambaiae only.
On physical examination, the products were ‘cream’ coloured, smooth and aromatic for the
eucalyptus oil creams, and light green, smooth and of a characteristic odour for Ocimum
gratissimum extract creams. The mean value ± SD for the rheological properties of the creams
were, particle size; F = 10.40; p < 0.1, spreadability; F = 0.32; p > 0.05, occlusivity; F =
11.81; p < 0.01 and pH; F = 2.89; p > 0.05.
IFEOMA, A (2021). Formulation And Evaluation Of Lipid Microparticle-Based Mosquito Repellent Cream. Afribary. Retrieved from https://afribary.com/works/formulation-and-evaluation-of-lipid-microparticle-based-mosquito-repellent-cream
IFEOMA, AGBO "Formulation And Evaluation Of Lipid Microparticle-Based Mosquito Repellent Cream" Afribary. Afribary, 13 May. 2021, https://afribary.com/works/formulation-and-evaluation-of-lipid-microparticle-based-mosquito-repellent-cream. Accessed 16 Oct. 2024.
IFEOMA, AGBO . "Formulation And Evaluation Of Lipid Microparticle-Based Mosquito Repellent Cream". Afribary, Afribary, 13 May. 2021. Web. 16 Oct. 2024. < https://afribary.com/works/formulation-and-evaluation-of-lipid-microparticle-based-mosquito-repellent-cream >.
IFEOMA, AGBO . "Formulation And Evaluation Of Lipid Microparticle-Based Mosquito Repellent Cream" Afribary (2021). Accessed October 16, 2024. https://afribary.com/works/formulation-and-evaluation-of-lipid-microparticle-based-mosquito-repellent-cream