Research Papers/Topics in Pharmaceutical Microbiology

Formulation and Evaluation of Some in Vitro and in Vivo Properties of Artemether-Loaded Self Emulsifying Drug Delivery System

ABSTRACT The aims of this research work were to formulate artemether-loaded self emulsifying drug delivery system (SEDDS), evaluate some of its in vitro and in vivo properties, and prevent drug precipitation through supersaturation approach. The solubility of artemether (ARM) in various oils, surfactants and cosurfactants was determined using the equilibrium solubility method. Vehicles such as Triacetin®, Labrasol® and Transcutol P® were selected as components of the formulation due to the...

Evaluation of the Antinociceptive and Anxiolytic-Like Activities of Leaf Extract and Fraction of Phyllanthus Muellerianus Kuntze

ABSTRACT The anxiolytic and antinociceptive properties of the leaf extract and fraction of Phyllanthus muellerianus Kuntze (Phyllanthaceae) were investigated.The extract (MME; 500.18 g; 10%w/w), obtained by cold maceration in 1:1 mixture of methylene chloride: methanol for 48 h, was fractionationed in a silica gel column which yielded the ethyl acetate fraction (EF; 199.2 g; 39.83% w/w). The extract and fraction were subjected to phytochemical analysis. Acute toxicity of MME was determined in...

Physico-Technical and Tableting Properties of Grades of Microcrystalline Cellulose Derived from Sorghum and Andropogon Plants

CONTENTS Page Acknowledgement ........................................................................................................... iv Abstract ................................................................................................................................. vi List of Tables .................................................................................................................... xiv List of Figures .................................................................

Phytochemical and Bioactivity-Guided Evaluation of the Antibacterial Constituents of Psidium Guajava (Linn.) and Loranthus Micranthus (Linn.) Leaves

ABSTRACT Antibiotics have remained the mainstay of drug therapy of infectious diseases worldwide. Their use is, however, limited by their numerous adverse effects and rapid development of microbial resistance. Identification of natural products from plants that may serve as valuable sources of antimicrobial agents for medicinal or agricultural uses seems to be a viable alternative to the conventional antibiotics. To achieve this goal, biological assays should be carried out in order to identi...

Comparative study of the anti-eczema and antifungal activities of Mitracarpus scaber with Sulphur ointments, Hydraulic fluid and Skineal on eczematous skin

Abstract Eczema, an atopic dermatitis is one of the most economically important skin disorder, therefore remedial attention needs to be given to it. Unlike the orthodox belief, eczema is a genetic disorder of the epidermis (filaggrin, CARD 11 or KIF3A gene mutation) not an infection, therefore, treatment must be targeted towards correcting this rather than targeting Candida albicans, the yeast that infects the eczematous skin as a result of environmental exposure. Currently, all types of chem...

Evaluation Of The Immunomodulatory Activity Of Hoslundia Opposita Vahl (Lamiaceae) Leaf Extract.

ABSTRACT The immunomodulatory properties of methanol extract and fractions of Hoslundia opposita leaf on Delayed-Type Hypersensitivity (DTH), primary and secondary humoral response and in vivo leucocyte mobilization were evaluated. Acute toxicity test of crude extract and phytochemistry study was carried out. The methanol extract (ME) at 200, 400 and 800 mg/kg body weight produced significant (P

Effects Of Heavy Metals On The Air Pollution Tolerance Indices ( Apti ) Of Five Medicinal Plants Growing Within Quarry Site In Ishi-Agu, Ebonyi State, Nigeria.

ABSTRACT Effects of heavy metals on the Air Pollution Tolerance Indices (APTI) of five medicinal plants growing within quarry site in Ishi-Agu, Ebonyi State, Nigeria were studied. Following laboratory analysis of the leaves of the plants for metal load and four biochemical parameters of APTI computation. The metal load was determined by the Atomic Absorption spectrophotometric method, while the ascorbic acid was determined by the titremetric method, leaf extract pH by the electro-chemical te...

Molecular Detection Of Extended- Spectrum Beta-Lactamases And Mcr-1 Genes In Gram Negative Isolated From Patient Of Urinary Tract Infections In Khartoum State

Abstract This study aimed to detect extended specterum beta lactamase genes in Gram negative bacteria associated with Urinary Tract Infections in Khartoum State. Ninty one urine specimens were collected in this study. Samples were cultured on CLED agar and bacteria were identified by the conventional biochemical methods. Modified Kirby-Bauer method was usedfor sensitivity testing by using the following antibiotics: Gentamicin, Ciprofloxacin, Co-trimoxazole, Imipenem and Ceftazidime. A total ...

Antifungal Capacity of Lactic Acid Bacteria Isolated From Salad Vegetables

ABSTRACT This study explores the use of lactic acid bacteria from fresh salad vegetables to inhibit fungal growth. The antifungal assay was done using the agar well diffusion method as reported by Schillinger and Lucke (1989). The largest zone of inhibition (25mm) was recorded by the antagonistic activity of the isolate identified to Lactobacillus plantarum against Candida albicans ATCC 90029. No activity was recorded against Candida parapsilosis ATCC 22019, C. valida UCH 1508, C. pseudotrop...

Preformulation Studies Of Cyperus Esculentus Starch Used As Disintegrant And As Binder In The Production Of Paracetamol Tablets

ABSTRACT Starch is a naturally occurring polymer found in parts of the plants such as leaves, stems, tubers, and fruits. It is a commonly used excipient in pharmaceutical formulations because of its availability, affordability and inertness. Cyperus esculentus (tiger nut) is widely cultivated in the country especially in the northern part of Nigeria. Until recently, the use of tiger nut had been limited to food products and few pharmaceutical applications. This research is aimed at character...

Prevalence, Molecular Characterization And Antibiotic Susceptibility Of Reproductive Tract Pathogens Isolated From Women Of Child Bearing Age

ABSTRACT Reproductive tract infections (RTIs) are a major public health problem especially in the developing world. As part of measures to control the spread of these infections, the World Health Organization recommended syndromic management. This study set out to determine the prevalence patterns, molecular characteristics and antibiotic susceptibility of reproductive tract pathogens isolated from women of child bearing age with the aim of contributing useful information to policy formulati...

Evaluation Of Anti-Ulcer Properties Of Methanol Extract Of Terminalia Superba Engl. & Diels (Combretaceae) Stem Bark

ABSTRACT Terminalia superba Engl. & Diels (Combretaceae), is a member of the genus Terminalia that comprises around 100 species distributed in tropical regions of the world. In Africa it is found along the coast of west and central Africa. It has different uses in traditional medicine such as antimalarial, anti-diabetic, anti-fungal, and anti-hypertensive in the areas where it is found. Most of these uses are yet to be scientifically investigated. The powdered stem bark of Terminalia superba...

A Comparative Study of Modified Starches in Direct Compression Tabletting.

ABSTRACT S t a r c h e s have t r a d i t i o n a l l y been used i n t h e pharmaceutical i n d u s t r y as f i l l e r , binder and d i s i n t e g r a n t . Pharmaceutical grade s t a r c h e s a r e derived mainly f r o m maize g r a i n s and potato tubers. C u r r e n t advances i n t a b l e t t i n g technology, e s p e c i a l l y the use of high-speed, mu1 ti-station r o t a r y t a b l e t presses, and d i r e c t compression t a b l e t t i n g t e c h n i q u e s , have n e c e ...


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