Research Papers/Topics in Pharmaceutical Microbiology

Evaluation Of The Immunomodulatory Activity Of Hoslundia Opposita Vahl (Lamiaceae) Leaf Extract.

ABSTRACTThe immunomodulatory properties of methanol extract and fractions of Hoslundia opposita leaf on Delayed-Type Hypersensitivity (DTH), primary and secondary humoral response and in vivoleucocyte mobilization were evaluated. Acute toxicity test of crude extract and phytochemistry study was carried out. The methanol extract (ME) at 200, 400 and 800 mg/kg body weightproduced significant (P

Effects Of Heavy Metals On The Air Pollution Tolerance Indices ( Apti ) Of Five Medicinal Plants Growing Within Quarry Site In Ishi-Agu, Ebonyi State, Nigeria.

ABSTRACTEffects of heavy metals on the Air Pollution Tolerance Indices (APTI) of fivemedicinal plants growing within quarry site in Ishi-Agu, Ebonyi State, Nigeriawere studied. Following laboratory analysis of the leaves of the plants for metalload and four biochemical parameters of APTI computation. The metal load wasdetermined by the Atomic Absorption spectrophotometric method, while theascorbic acid was determined by the titremetric method, leaf extract pH by theelectro-chemical tec...

Molecular Detection Of Extended- Spectrum Beta-Lactamases And Mcr-1 Genes In Gram Negative Isolated From Patient Of Urinary Tract Infections In Khartoum State

AbstractThis study aimed to detect extended specterum beta lactamase genes in Gramnegative bacteria associated with Urinary Tract Infections in Khartoum State.Ninty one urine specimens were collected in this study. Samples were cultured onCLED agar and bacteria were identified by the conventional biochemical methods.Modified Kirby-Bauer method was usedfor sensitivity testing by using thefollowing antibiotics: Gentamicin, Ciprofloxacin, Co-trimoxazole, Imipenem andCeftazidime. A total of...

Antifungal Capacity of Lactic Acid Bacteria Isolated From Salad Vegetables

ABSTRACT This study explores the use of lactic acid bacteria from fresh salad vegetables to inhibit fungal growth. The antifungal assay was done using the agar well diffusion method as reported by Schillinger and Lucke (1989). The largest zone of inhibition (25mm) was recorded by the antagonistic activity of the isolate identified to Lactobacillus plantarum against Candida albicans ATCC 90029. No activity was recorded against Candida parapsilosis ATCC 22019, C. valida UCH 1508, C. ...

Preformulation Studies Of Cyperus Esculentus Starch Used As Disintegrant And As Binder In The Production Of Paracetamol Tablets

ABSTRACTStarch is a naturally occurring polymer found in parts of the plants such asleaves, stems, tubers, and fruits. It is a commonly used excipient inpharmaceutical formulations because of its availability, affordability andinertness. Cyperus esculentus (tiger nut) is widely cultivated in the countryespecially in the northern part of Nigeria. Until recently, the use of tiger nut hadbeen limited to food products and few pharmaceutical applications. Thisresearch is aimed at character...

Prevalence, Molecular Characterization And Antibiotic Susceptibility Of Reproductive Tract Pathogens Isolated From Women Of Child Bearing Age

ABSTRACTReproductive tract infections (RTIs) are a major public health problem especially in thedeveloping world. As part of measures to control the spread of these infections, the WorldHealth Organization recommended syndromic management. This study set out to determinethe prevalence patterns, molecular characteristics and antibiotic susceptibility of reproductivetract pathogens isolated from women of child bearing age with the aim of contributing usefulinformation to policy formulation...

Evaluation Of Anti-Ulcer Properties Of Methanol Extract Of Terminalia Superba Engl. & Diels (Combretaceae) Stem Bark

ABSTRACTTerminalia superba Engl. & Diels (Combretaceae), is a member of the genus Terminalia thatcomprises around 100 species distributed in tropical regions of the world. In Africa it is foundalong the coast of west and central Africa. It has different uses in traditional medicine such asantimalarial, anti-diabetic, anti-fungal, and anti-hypertensive in the areas where it is found.Most of these uses are yet to be scientifically investigated. The powdered stem bark ofTerminalia superb...

A Comparative Study of Modified Starches in Direct Compression Tabletting.

ABSTRACTS t a r c h e s have t r a d i t i o n a l l y been used i n t h epharmaceutical i n d u s t r y as f i l l e r , binder and d i s i n t e g r a n t .Pharmaceutical grade s t a r c h e s a r e derived mainly f r o m maizeg r a i n s and potato tubers.C u r r e n t advances i n t a b l e t t i n g technology, e s p e c i a l l ythe use of high-speed, mu1 ti-station r o t a r y t a b l e t presses,and d i r e c t compression t a b l e t t i n g t e c h n i q u e s , haven e c e s s i t ...

A Comparative Study of Modified Starches in Direct Compression Tabletting

ABSTRACTS t a r c h e s have t r a d i t i o n a l l y been used i n t h epharmaceutical i n d u s t r y as f i l l e r , binder and d i s i n t e g r a n t .Pharmaceutical grade s t a r c h e s a r e derived mainly f r o m maizeg r a i n s and potato tubers.C u r r e n t advances i n t a b l e t t i n g technology, e s p e c i a l l ythe use of high-speed, mu1 ti-station r o t a r y t a b l e t presses,and d i r e c t compression t a b l e t t i n g t e c h n i q u e s , haven e c e s s i t ...

Formulation And Evaluation Of Lipid Microparticle-Based Mosquito Repellent Cream

ABSTRACTIn the tropics, malaria has become the most alarming public health problem, hence the needfor a mosquito repellent, a personal protection against the vector. The concern about thedeleterious effects associated with synthetic chemicals like N, N-diethy-3-methylbenzamide(DEET) has elicited the interest to explore plant materials as source of natural repellent formosquito control. The aim of this study was to formulate and evaluate herbal mosquitorepellent cream based on solid lipi...

Use Of Prosopis Africana Seed Hydrolysate As Peptone Source For Microbial Growth Media

ABSTRACTThere is a growing industrial demand for peptones of non-animal origin owing to legislations aswell as outbreak of animal-associated diseases. Microbiological growth media developed fromlegumes as sources of protein hydrolysates are limited. It is, therefore, the aim of this study, toproduce comparatively standard protein hydrolysates from Prosopis africanaseed that can beused as peptone for microbial culture in place of animal peptone.Prosopis africana seeds (2.5kg) were purch...

Antioxidant And Hepatoprotective Studies Of Annonasenegalensispers. (Annonaceae) Stem Bark.

AbstractThe study was carried out to determine pharmacognostic standards, phytochemical constituents,evaluate the antioxidant and hepatoprotective activities of the extract and fractions of Annonasenegalensis Pers. (Annonaceae) by employing both the in vitro and in vivo experimentalmodels. The acute toxicity tests result showed the drug is safe at 5000mg/kg doses.The effect of DPPH free radical scavenging, ABTS radical scavenging, Hydroxyl radicalscavenging, Hydrogen peroxide scaven...

In-vitro Antimicrobial Activities of Methanol Extracts of Zanthoxylum xanthoxyloides and Pseudocedrela kotschyi

ABSTRACT  The antimicrobial activities of two Nigerian medicinal plant commonly used as chewing sticks Zanthoxylum xanthoxyloides and Pseudocedrela kotschyi antimicrobial activities were investigated against 7clinical strains of Streptococcus mutans, Staphylococcus aureus ATCC 29213, Candida albicans, Candida tropicalis and Candida krusei ATCC 6825. The antibacterial and antifungal activities of the extracts were determined using the agar well diffusion and surface plate met...


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