ABSTRACT Pregelatinized Chinese yam (Dioscorea oppositifolia) starch has been evaluated as a polymer for the formulation of floating gastroretentive
beads for the controlled delivery of metformin hydrochloride. Floating microbeads were prepared by the ionotropic gelation method using a blend
of modified Chinese yam starch and sodium alginate at different ratios. Sodium bicarbonate was added as a gas-generating agent. The floating
microbeads were characterized by SEM, DSC, FTIR analyses and the drug entrapment efficiency and floating ability was evaluated. Drug release
was investigated using in vitro dissolution test and the results were fitted to various kinetic models to determine the mechanism(s) of release.
Spherical, discrete and free flowing microbeads were obtained from the modified starch-alginate blends. Minimum lag time (< 20 s) was observed
for the floating microbeads containing starch and buoyancy was maintained for 12 h. The release of MET from the floating microbeads appeared
to be controlled by varying the starch to alginate polymer ratio. In general, the formulations followed diffusion and erosion mechanisms of drug
release. The results suggest that modified Chinese yam starch-sodium alginate blend can be useful for the formulation of floating gastroretentive
system for metformin hydrochloride.
Okunlola, A (2021). Evaluation of freeze-dried pregelatinized Chinese yam (Dioscorea oppositifolia) starch as a polymer in floating gastroretentive metformin microbeads. Afribary. Retrieved from https://afribary.com/works/evaluation-of-freeze-dried-pregelatinized-chinese-yam-dioscorea-oppositifolia-starch-as-a-polymer-in-floating-gastroretentive-metformin-microbeads
Okunlola, A. "Evaluation of freeze-dried pregelatinized Chinese yam (Dioscorea oppositifolia) starch as a polymer in floating gastroretentive metformin microbeads" Afribary. Afribary, 21 Apr. 2021, https://afribary.com/works/evaluation-of-freeze-dried-pregelatinized-chinese-yam-dioscorea-oppositifolia-starch-as-a-polymer-in-floating-gastroretentive-metformin-microbeads. Accessed 04 May. 2024.
Okunlola, A. . "Evaluation of freeze-dried pregelatinized Chinese yam (Dioscorea oppositifolia) starch as a polymer in floating gastroretentive metformin microbeads". Afribary, Afribary, 21 Apr. 2021. Web. 04 May. 2024. < https://afribary.com/works/evaluation-of-freeze-dried-pregelatinized-chinese-yam-dioscorea-oppositifolia-starch-as-a-polymer-in-floating-gastroretentive-metformin-microbeads >.
Okunlola, A. . "Evaluation of freeze-dried pregelatinized Chinese yam (Dioscorea oppositifolia) starch as a polymer in floating gastroretentive metformin microbeads" Afribary (2021). Accessed May 04, 2024. https://afribary.com/works/evaluation-of-freeze-dried-pregelatinized-chinese-yam-dioscorea-oppositifolia-starch-as-a-polymer-in-floating-gastroretentive-metformin-microbeads