Objective: Lubricants are additives which reduce friction and so essential components of drug
formulation. This piece of work was initiated to evaluate coconut oil as a co-processed lubricant in
the formulation and compression of paracetamol tablets in comparison with magnesium stearatetalc as standard lubricant.
Methods: Various concentrations 0.5, 1.5, 2.0 and 2.5% w
/w lubricant mixtures of magnesium
stearate-talc (MT), coconut magnesium stearate-talc (CMT), magnesium stearate (M), coconut oil
alone (C) respectively; and without lubricant (None) which served as control were thoroughly mixed
with granules (200 mg) prepared from the basic formula for paracetamol tablets which contained
/w, 5% w
/w and 10% w
/w of paracetamol powder, corn starch and lactose respectively. The
mechanical properties of tablets produced were evaluated using crushing strength, friability and
crushing strength -friability ratio while the release properties of tablets were evaluated using
disintegration and dissolution tests.
Results: Granules lubricated with coconut oil co-processed with magnesium stearate had
excellent flow. The crushing strength obtained for all the paracetamol tablets had acceptable values ranging from 4.82 to 6.85 kgf except for tablets lubricated with coconut oil alone. Generally,
as the crushing strength values increased the friability decreased. Friability values for all the tablets
generally decreased with increasing tablet lubricant concentrations of 2.0% w
/w and 2.5% w
though falling within range considered for conventional tablets. The disintegration time increased
with increase in lubricant concentration as all the tablets had acceptable values. Tablets lubricated
with coconut oil mixed with magnesium stearate-talc showed the highest CSFR/DT ratio. As the
concentration of lubricant increased, there was a general decrease in the rate and extent of the
drug release from the formulation.
Conclusion: Coconut oil is an effective lubricant which can be processed with magnesium
stearate and talc for an effective lubrication of granules before compression into pharmaceutical
Eyituoyo, L (2020). Lubricating Properties of Co-processed Coconut oil in Paracetamol Tablet Formulation. Afribary.com: Retrieved December 03, 2020, from https://afribary.com/works/lubricating-properties-of-co-processed-coconut-oil-in-paracetamol-tablet-formulation
Lori, Eyituoyo. "Lubricating Properties of Co-processed Coconut oil in Paracetamol Tablet Formulation" Afribary.com. Afribary.com, 16 Jul. 2020, https://afribary.com/works/lubricating-properties-of-co-processed-coconut-oil-in-paracetamol-tablet-formulation . Accessed 03 Dec. 2020.
Lori, Eyituoyo. "Lubricating Properties of Co-processed Coconut oil in Paracetamol Tablet Formulation". Afribary.com, Afribary.com, 16 Jul. 2020. Web. 03 Dec. 2020. < https://afribary.com/works/lubricating-properties-of-co-processed-coconut-oil-in-paracetamol-tablet-formulation >.
Lori, Eyituoyo. "Lubricating Properties of Co-processed Coconut oil in Paracetamol Tablet Formulation" Afribary.com (2020). Accessed December 03, 2020. https://afribary.com/works/lubricating-properties-of-co-processed-coconut-oil-in-paracetamol-tablet-formulation