Lubricating Properties of Co-processed Coconut oil in Paracetamol Tablet Formulation

Eyituoyo Lori Majekodunmi S.O Lori E 10 PAGES (4908 WORDS) Article
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ABSTRACT 

Objective: Lubricants are additives which reduce friction and so essential components of drug 

formulation. This piece of work was initiated to evaluate coconut oil as a co-processed lubricant in 

the formulation and compression of paracetamol tablets in comparison with magnesium stearate￾talc as standard lubricant. 

Methods: Various concentrations 0.5, 1.5, 2.0 and 2.5% w

/w lubricant mixtures of magnesium 

stearate-talc (MT), coconut magnesium stearate-talc (CMT), magnesium stearate (M), coconut oil 

alone (C) respectively; and without lubricant (None) which served as control were thoroughly mixed 

with granules (200 mg) prepared from the basic formula for paracetamol tablets which contained 

85% w

/w, 5% w

/w and 10% w

/w of paracetamol powder, corn starch and lactose respectively. The 

mechanical properties of tablets produced were evaluated using crushing strength, friability and 

crushing strength -friability ratio while the release properties of tablets were evaluated using 

disintegration and dissolution tests. 

Results: Granules lubricated with coconut oil co-processed with magnesium stearate had 

excellent flow. The crushing strength obtained for all the paracetamol tablets had acceptable values ranging from 4.82 to 6.85 kgf except for tablets lubricated with coconut oil alone. Generally, 

as the crushing strength values increased the friability decreased. Friability values for all the tablets 

generally decreased with increasing tablet lubricant concentrations of 2.0% w

/w and 2.5% w

/w 

though falling within range considered for conventional tablets. The disintegration time increased 

with increase in lubricant concentration as all the tablets had acceptable values. Tablets lubricated 

with coconut oil mixed with magnesium stearate-talc showed the highest CSFR/DT ratio. As the 

concentration of lubricant increased, there was a general decrease in the rate and extent of the 

drug release from the formulation. 

Conclusion: Coconut oil is an effective lubricant which can be processed with magnesium 

stearate and talc for an effective lubrication of granules before compression into pharmaceutical 

tablets. 

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APA

Eyituoyo, L (2020). Lubricating Properties of Co-processed Coconut oil in Paracetamol Tablet Formulation. Afribary.com: Retrieved December 03, 2020, from https://afribary.com/works/lubricating-properties-of-co-processed-coconut-oil-in-paracetamol-tablet-formulation

MLA 8th

Lori, Eyituoyo. "Lubricating Properties of Co-processed Coconut oil in Paracetamol Tablet Formulation" Afribary.com. Afribary.com, 16 Jul. 2020, https://afribary.com/works/lubricating-properties-of-co-processed-coconut-oil-in-paracetamol-tablet-formulation . Accessed 03 Dec. 2020.

MLA7

Lori, Eyituoyo. "Lubricating Properties of Co-processed Coconut oil in Paracetamol Tablet Formulation". Afribary.com, Afribary.com, 16 Jul. 2020. Web. 03 Dec. 2020. < https://afribary.com/works/lubricating-properties-of-co-processed-coconut-oil-in-paracetamol-tablet-formulation >.

Chicago

Lori, Eyituoyo. "Lubricating Properties of Co-processed Coconut oil in Paracetamol Tablet Formulation" Afribary.com (2020). Accessed December 03, 2020. https://afribary.com/works/lubricating-properties-of-co-processed-coconut-oil-in-paracetamol-tablet-formulation