ABSTRACT Background: The global burden of Hepatocellular Carcinoma (HCC) has increased. Consequently, exploring newer treatment modalities for HCC such as herbal medicines has become a necessary. Objective: The study investigated antiHCC effects of an alkaloidal extract derived from leaves of Zanthoxylum zanthoxyloides. Materials and methods: Alkaloidal extract (ZZAE) from cleaned dried leaves of Zanthoxylum zanthoxyloides was prepared using Soxhlet extraction and liquid-liquid extraction m...