Research Papers/Topics in Haematology

A Study Of Coagulation Profile In Sickle Cell Anaemia Patients With And Without Chronic Leg Ulcers At The Ghana Institute Of Clinical Genetics, Accra

ABSTRACTBackground: Sickle Cell Anaemia (SCA), the most common form of sickle cell disease (SCD), is associated with elevation of thrombotic factors and depression of anticoagulants, resulting in venous thrombotic events. Sickle Cell Anaemia patients suffer from recurrent, painful, slow-to-heal leg ulcers. Chronic leg ulcer (CLU) in sickle cell anaemia, may not lead to fatal outcomes though, but is associated with aesthetic deformity and reduced quality of life. The pathogenesis of CLU in SCA...

The Role Of Human T-Cell Lymphotropic Virus Type 1 (Htlv-1) Infections In Haematological Malignancies

ABSTRACT  Background: The Human T-Cell Lymphotropic Virus (HTLV) was first recognized in the 1980s by Poiesz et al and was the first retrovirus identified in human. HTLVs are human retroviruses identified as the causative agents of Adult T-Cell Leukemia/Lymphoma (ATLL), a lymphoproliferative malignancy of CD4+ activated cells and HTLV-1 associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), a demyelinating disease. There is a significant association of HTLV 1 with lymphoid m...

Prevalence of Blood Group A2 among Group A and Ab Donors who Visit the Southern Area Blood Centre

ABSTRACT Introduction: The ABO blood group antigens are major antigens whose discovery paved way for the performance of safe blood transfusions and transplantations. Subgroups of the ABO antigens were discovered few years after ABO antigens discovery. A1 and A2 are the two principal subgroups of A, both of which are produced by different enzymes. Anti-A1 antibody appears as an atypical cold agglutinin in the sera of some individuals with A2 or A2B who lack the corresponding antigen. One...