Research Papers/Topics in Haematology

Hematological profiles and Human Leukocyte Antigen-class II Alleles in Systemic Lupus Erythrematosus among Sudanese Patients

Abstract:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production that can result in damage to multiple organ systems. The present study aimed to investigate Human Leukocyte Antigen class II in Systemic lupus erythromatous (SLE) Sudanese patients, the Anti nuclear auto antibodies profile in patient, the antiphospholipid autoantibodies as well as hematological abnormalities. Eighty SLE patients and sixty matching ethnicity and sex healthy c...

Haematological Reference Intervals For Adolescents And Adults In Nakuru County, Kenya

ABSTRACTThe haematologic reference intervals are important in the assessment of health anddiseases conditions in a certain population and they vary with to age, sex, altitude andgenetic. The current study intended to establish the haematological reference intervals inNakuru County, Kenya. A cross sectional design was used where samples of blood werecollected from consenting participants. The number of participants recruited for the studywas 627 and they aged 13 to 18 years for the adole...

Quantization of Hemoglobin Types among sickle Cell Anemia Patients Attending Medical Army Hospital in Khartoum State

This is prospective, analytical and cross- sectional study carried out in Medical Army hospital in Khartoum State, during April 2015 - July 2015. Forty sickle cell disease patients were studied, 18 were males and 22 were females, their ages 1-13 years, 23(58%) were sickle cell anemia (HbSS), 17(42%) were sickle cell trait (HbAS) as known cases by hemoglobin electrophoresis. The aim of this study to measure the level different hemoglobin types in the study group a...

Association of Glutathione –S Transeferese Theta 1 Null Polymorphism among Sudanese Patients with Chronic Myeloid Leukemia

The GSTT1 is play a crucial function in the detoxification of both endogenous and exogenous carcinogens and also participate in the activation and inactivation of oxidative metabolites of carcinogenic compounds so that to protect DNA from oxidative damage. Hence, it has been speculated that GSTs were probably involved in the development of cancers. The objective of this study to investigate the association of null glutathione S-transeferase theta 1 (GSTT1) genotype am...

Detection of Tissue Factor Pathway Inhibitor-2 Gene Mutation and its Correlation with Coagulaton Parameters in Sudanese Pediatric Patients with Leukemia

This is analytical case control study was carried out in radio isotope center Khartoum (RICK) to detect TFPI-2 gene mutation and its correlation with coagulation parameter in Sudanese pediatric patients with leukemia. Ninety-eight patients less than 15 years with mean age for all (9.03 ± 4.058) where diagnosed with leukemia of both gender 52 (53.1%) were males and 46 (46.9%) were females.The center administration and the relatives of the patients were informed about the study ...

Blood Lead Levels And Selected Hematological Parameters Among at Risk Occupational Groups And Blood Donors in Kenyasi, Brong Ahafo Region

ABSTRACT Introduction: Lead poisoning has been a major public health problem for decades across the world and receiving a blood transfusion has been considered as a risk factor for lead exposure. Children and pregnant women are most vulnerable to the toxic effects of lead. However, over 40% of transfused blood in Ghana is given to children below the age of 5 years. Among adults, occupation is the leading cause of elevated blood lead levels (EBLL). Aim: This study compared blood lead le...

A Study Of Coagulation Profile In Sickle Cell Anaemia Patients With And Without Chronic Leg Ulcers At The Ghana Institute Of Clinical Genetics, Accra

ABSTRACTBackground: Sickle Cell Anaemia (SCA), the most common form of sickle cell disease (SCD), is associated with elevation of thrombotic factors and depression of anticoagulants, resulting in venous thrombotic events. Sickle Cell Anaemia patients suffer from recurrent, painful, slow-to-heal leg ulcers. Chronic leg ulcer (CLU) in sickle cell anaemia, may not lead to fatal outcomes though, but is associated with aesthetic deformity and reduced quality of life. The pathogenesis of CLU in SCA...

The Role Of Human T-Cell Lymphotropic Virus Type 1 (Htlv-1) Infections In Haematological Malignancies

ABSTRACT  Background: The Human T-Cell Lymphotropic Virus (HTLV) was first recognized in the 1980s by Poiesz et al and was the first retrovirus identified in human. HTLVs are human retroviruses identified as the causative agents of Adult T-Cell Leukemia/Lymphoma (ATLL), a lymphoproliferative malignancy of CD4+ activated cells and HTLV-1 associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), a demyelinating disease. There is a significant association of HTLV 1 with lymphoid m...

Prevalence of Blood Group A2 among Group A and Ab Donors who Visit the Southern Area Blood Centre

ABSTRACT Introduction: The ABO blood group antigens are major antigens whose discovery paved way for the performance of safe blood transfusions and transplantations. Subgroups of the ABO antigens were discovered few years after ABO antigens discovery. A1 and A2 are the two principal subgroups of A, both of which are produced by different enzymes. Anti-A1 antibody appears as an atypical cold agglutinin in the sera of some individuals with A2 or A2B who lack the corresponding antigen. One...