ABSTRACT PURPOSE: To investigate the effectiveness of three natural gums, namely albizia, cissus and khaya gums, as excipients for the formulation of ibuprofen microbeads. METHODS: Ibuprofen microbeads were prepared by the ionotropic gelation method using the natural gums and their blends with sodium alginate at various concentrations using different chelating agents (calcium chloride, zinc chloride, calcium acetate and zinc acetate) at different concentrations. Microbeads were assessed ...
ABSTRACT Obesity and type 2 diabetes mellitus constitute major public health issues in modern societies worldwide. They have been linked in several ways. Obesity is involved in the pathologic process that culminates in the development of type 2 diabetes. The aim of this study was to assess the frequency of obesity in known type 2 diabetic patients and also to determine the presence of comorbidities associated with these two conditions. The study was carried out at Lagos University Teaching ho...
Abstract The compressional characteristics and tableting properties of starches from four yam species namely Dioscorea dumetorum Pax (Bitter); Dioscorea oppositifolia L (Chinese); Dioscorea alata L.DIAL2 (Water) and Dioscorea rotundata Poir (White) were investigated in comparison with corn starch. The physicochemical properties of the starches were evaluated using established methods while the compressional characteristics were analyzed using density measurements, and the Heckel and Kawakita ...
ABSTRACT As chloroquine and ciprofloxacin each possess substantial inhibitory activity against the schizonts of Plasmodium falciparum, it seems possible that a combination of the two drugs may be clinically useful. The effects on the erythrocytic stages of P. falciparum of combined treatment with chloroquine and ciprofloxacin were therefore evaluated in vitro, using the World Health Organization’s standardized micro test. When used alone, the median inhibitory concentration (IC50) of chloro...
ABSTRACT Drug-use pattern of anti-malarial has been associated with development of resistant strain and therapeutic failure. This descriptive cross-sectional study was carried out to assess anti-malarial drug-use practices among dwellers of Adigbe communities within Abeokuta environment. The study documented the knowledge, the attitude and behaviour of three hundred and fifty (350) respondents in terms of drug preference, attitude to drug use and the effects of non-compliance to antimalarial...
As the computer becomes more and more powerful, its uses and abilities grow. Scientists have been able to harness this power in to assist them in their goals of researching and developing drugs for human use. Computers can be found in nearly every drug research laboratory and development center in the world.