ABSTRACT Malaria caused by P. falciparum, is the most life-threatening human parasitic disease, claiming over 400,000 deaths from about 200 million cases in 2017. Despite the yet unsuccessful efforts in the quest for an effective malaria vaccine, antigens expressed in the erythrocytic stage of P. falciparum represent highly promising vaccine candidates given their natural exposure to the immune system. Understanding the mechanism of erythrocyte invasion by P. falciparum mainly during active c...
ABSTRACT Background Placental malaria and preeclampsia are major complications of pregnancy associated with high incidence of maternal/foetal morbidity and mortality particularly in sub-Saharan Africa. Similarities in pathophysiology such as systemic inflammation and generalized endothelial activation/dysfunction exist and are exacerbated in concurrent situations. The combined pathologic and immunologic effects of these pregnancy disorders, prevalent in malaria endemic regions, have not been ...
ABSTRACT Malaria still poses a global threat despite the enormous research and intervention strategies that have been employed to curb the menace of the disease over the years. This has necessitated the characterization of novel drug targets for the development of new intervention against malaria. In this study, I identified two novel P. falciparum proteins (PF3D7_0410600 and PF3D7_1459400) and used cellular/biochemical approaches to characterize the proteins. Analysis of the protein sequenc...
Table of ContentsAcknowledgements .................................................................................................................. IIAbstract ................................................................................................................................... III List of tables ........................................................................................................................... VIList of figures ...............................................