In-vitro Bactericidal Kinetics of Chlorhexidine Gluconate Disinfectant/ Antiseptic Formulations Containing Different Additives

ABSTRACT

Chlorhexidine gluconate(CHG) is a popular disinfectant/antiseptic which is often formulated with additives. We investigated the effect of additives type on the in vitro bactericidal kinetics of CHG in three commercially available formulations: Hibiscrub®, Savlon® and Purit® commonly used as household and hospital disinfectants/antiseptics. The bactericidal kinetics of the products was determined by time-survival curve method using Pseudomonas aeruginosa NCTC 6750 and Staphylococcus aureus NCTC 6571 as model organisms. Best-fit rate constant and half-life was computed by exponential decay curve-fitting. Half-life was; 76.5, 65.5, 66 and 74 (min) for Control solution, Hibiscrub®, Savlon® and Purit® respectively, against Ps. aeruginosa. The corresponding values obtained against Staph. aureus are 51.0, 61.7, 29.3, and 49.0 (min) (95% CI). Presence of alcohol (e.g. Hibiscrub® and Savlon®) caused an insignificant increase in the rate of killing of Ps. aeruginosa relative to preparations that are devoid of alcohol. (p>0.05, 1-way ANOVA). Toward Staphylococcus aureus, the combined effect of cetrimide and alcohol (e.g. Savlon®) is higher than any enhancement due to combination of alcohol and surfactant (e.g. Hibiscrub). Savlon® show a significantly higher bactericidal effect of all the preparations (P

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APA

A, I & S, I (2021). In-vitro Bactericidal Kinetics of Chlorhexidine Gluconate Disinfectant/ Antiseptic Formulations Containing Different Additives. Afribary. Retrieved from https://afribary.com/works/in-vitro-bactericidal-kinetics-of-chlorhexidine-gluconate-disinfectant-antiseptic-formulations-containing-different-additives

MLA 8th

A, IDOWU and IDOWU S "In-vitro Bactericidal Kinetics of Chlorhexidine Gluconate Disinfectant/ Antiseptic Formulations Containing Different Additives" Afribary. Afribary, 17 Mar. 2021, https://afribary.com/works/in-vitro-bactericidal-kinetics-of-chlorhexidine-gluconate-disinfectant-antiseptic-formulations-containing-different-additives. Accessed 27 May. 2024.

MLA7

A, IDOWU, IDOWU S . "In-vitro Bactericidal Kinetics of Chlorhexidine Gluconate Disinfectant/ Antiseptic Formulations Containing Different Additives". Afribary, Afribary, 17 Mar. 2021. Web. 27 May. 2024. < https://afribary.com/works/in-vitro-bactericidal-kinetics-of-chlorhexidine-gluconate-disinfectant-antiseptic-formulations-containing-different-additives >.

Chicago

A, IDOWU and S, IDOWU . "In-vitro Bactericidal Kinetics of Chlorhexidine Gluconate Disinfectant/ Antiseptic Formulations Containing Different Additives" Afribary (2021). Accessed May 27, 2024. https://afribary.com/works/in-vitro-bactericidal-kinetics-of-chlorhexidine-gluconate-disinfectant-antiseptic-formulations-containing-different-additives