Background: Dengue and malaria are two important mosquito-borne diseases.
Together, both diseases are indistinguishable due to similarities in clinical and
laboratory characteristics. These similarities have contributed immensely to the overdiagnosis of malaria and the under-recognition of dengue in many countries in subSaharan Africa. No baseline study has yet been conducted in Ghana to estimate the
burden of dengue. This study therefore set out to estimate the prevalence of dengue
infection in a population of Ghanaian children confirmed with malaria.
Methods: Archived plasma samples, obtained from 216 study participants aged 2-14
years enrolled in a malaria study, were tested for the presence of dengue using RealTime Reverse Transcriptase PCR, dengue Rapid Diagnostic Test (RDT) and dengue
IgM/IgG capture ELISA. The study was conducted in three ecological zones of Ghana
namely: Kintampo, Navrongo and Accra.
Results: Dengue RDT and dengue IgM/IgG capture ELISAs estimated a prevalence of
54% and 24%, respectively. Dengue IgG capture ELISA showed that majority of
seropositive study participants were positive for IgG (20%) and this was statistically
significant between Kintampo and Navrongo. Estimated IgM/IgG ratio of 0.11
indicated that dengue infection was as a consequence of a previous exposure. Further
analysis showed that 22% of the study population were confirmed with exposure to
dengue-malaria while exposure to malaria only, dengue only and absence of either
diseases was confirmed in 70%, 2% and 6% of study population respectively.
Molecular tests indicated negative for dengue in all study participants.
Conclusion: Results in the study suggest an exposure to dengue virus in a subset of
Ghanaian population. However, the inability to detect and identify circulating serotype
calls for more research in this regard
CDR, C (2021). INVESTIGATION OF DENGUE EXPOSURE AND INFECTION IN GHANAIAN CHILDREN WITH MALARIA. Afribary.com: Retrieved April 10, 2021, from https://afribary.com/works/investigation-of-dengue-exposure-and-infection-in-ghanaian-children-with-malaria-1
Coalition, CDR. "INVESTIGATION OF DENGUE EXPOSURE AND INFECTION IN GHANAIAN CHILDREN WITH MALARIA" Afribary.com. Afribary.com, 05 Apr. 2021, https://afribary.com/works/investigation-of-dengue-exposure-and-infection-in-ghanaian-children-with-malaria-1 . Accessed 10 Apr. 2021.
Coalition, CDR. "INVESTIGATION OF DENGUE EXPOSURE AND INFECTION IN GHANAIAN CHILDREN WITH MALARIA". Afribary.com, Afribary.com, 05 Apr. 2021. Web. 10 Apr. 2021. < https://afribary.com/works/investigation-of-dengue-exposure-and-infection-in-ghanaian-children-with-malaria-1 >.
Coalition, CDR. "INVESTIGATION OF DENGUE EXPOSURE AND INFECTION IN GHANAIAN CHILDREN WITH MALARIA" Afribary.com (2021). Accessed April 10, 2021. https://afribary.com/works/investigation-of-dengue-exposure-and-infection-in-ghanaian-children-with-malaria-1