Abstract:
Several medicinal plants have anti-diabetic properties and can be considered as an alternative therapy because of their actions which are like those of conventional antidiabetic drugs. In this study, we investigated Myrothamnus flabellifolius (MF) ethanol: water (70:30) extract for its possible anti-diabetic potential in streptozotocin-high energy diet (STZ-HED) induced type 2 diabetes mellitus (T2DM) rats and its possible mechanisms of action. Diabetic rats were divided into MF-50, MF-100, MF200, MF-300, MF400, and Metformin (MET)-500 groups, where the numbers represent doses in
mg.kg.bw that were administered to the groups. Normal (NC) and diabetic (DC) controls were administered distilled water. The animals had their fasting blood glucose levels and body weights determined weekly for 21 days. Blood samples, liver, pancreas, and muscle were collected and used for biochemical and histological examination. Our study showed that MF extract lowered glucose levels, body weight, glycated hemoglobin, thiobarbituric acid reactive substances, serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, Homeostatic model assessment of insulin resistance, and
alkaline phosphatase (p
Elvis, K (2024). Myrothamnus flabellifolius attenuates streptozotocin-high energy diet-induced type 2 diabetes in male sprague dawley rats. Afribary. Retrieved from https://afribary.com/works/myrothamnus-flabellifolius-attenuates-streptozotocin-high-energy-diet-induced-type-2-diabetes-in-male-sprague-dawley-rats
Elvis, Kwape "Myrothamnus flabellifolius attenuates streptozotocin-high energy diet-induced type 2 diabetes in male sprague dawley rats" Afribary. Afribary, 30 Mar. 2024, https://afribary.com/works/myrothamnus-flabellifolius-attenuates-streptozotocin-high-energy-diet-induced-type-2-diabetes-in-male-sprague-dawley-rats. Accessed 01 May. 2024.
Elvis, Kwape . "Myrothamnus flabellifolius attenuates streptozotocin-high energy diet-induced type 2 diabetes in male sprague dawley rats". Afribary, Afribary, 30 Mar. 2024. Web. 01 May. 2024. < https://afribary.com/works/myrothamnus-flabellifolius-attenuates-streptozotocin-high-energy-diet-induced-type-2-diabetes-in-male-sprague-dawley-rats >.
Elvis, Kwape . "Myrothamnus flabellifolius attenuates streptozotocin-high energy diet-induced type 2 diabetes in male sprague dawley rats" Afribary (2024). Accessed May 01, 2024. https://afribary.com/works/myrothamnus-flabellifolius-attenuates-streptozotocin-high-energy-diet-induced-type-2-diabetes-in-male-sprague-dawley-rats