ABSTRACT
Exposure to environmental toxicant was known to cause neuronal disorders in humans. Hence, the present study evaluates the toxic effect of leachate (an environmental toxicant) in the synaptosomes of female rats and the reversal effect of phenolic-rich fraction from Croton zambesicus. Fifty animals were divided into five groups. Group I (Control) received 0.5ml of distilled water only, Group II (non-withdrawal) received 0.5ml of leachate for 14 weeks, Group III (withdrawal) received 0.5ml of leachate for 11 weeks and withdrawn for 3 weeks, Group IV (L+EXTRACT) received 0.5ml of leachate for 11 weeks and 400mg/kg extract for 3 weeks, Lastly, Group V (EXTRACT ONLY) received 400mg/kg extract only for 3 weeks. The experiment lasted for 14 weeks. Both non-withdrawal and withdrawal exposure of animals to leachate caused oxidative and neuronal damage. This study suggests that battery recycling site leachate elicits damage in female rats’ synaptosomes by increasing the malondialdehyde level, and decreasing Reduced glutathione level. The activities of catalase, superoxide dismutase, Lactate dehydrogenase and other enzymatic antioxidants were decreased, also the activities of aminerging catabolizing enzymes i.e Acetylcholinesterase, Butyrylcholinesterase and Monoamine oxidase were also elevated. The phenolic-rich fraction from Croton zambesicus significantly reversed the toxicity. The preventive and protective effect of phenolic compounds (Gallic acid, Caffeic acid, Quercetin, Luteolin and Apigenin) from phenolic-rich fraction from Croton zambesicus validates that they have therapeutic application in neuronal and oxidative damage of the brain.
Ibrahim, L. & K., D (2018). Neuroprotective Effect of Croton Zambesicus Phenolic Extract on Synaptosomes of Rats Exposed to Environmental Toxicant. Afribary. Retrieved from https://afribary.com/works/neuroprotective-effect-of-croton-zambesicus-phenolic-extract-on-synaptosomes-of-rats-exposed-to-environmental-toxicant
Ibrahim, Latifat, and Dr. K. "Neuroprotective Effect of Croton Zambesicus Phenolic Extract on Synaptosomes of Rats Exposed to Environmental Toxicant" Afribary. Afribary, 07 May. 2018, https://afribary.com/works/neuroprotective-effect-of-croton-zambesicus-phenolic-extract-on-synaptosomes-of-rats-exposed-to-environmental-toxicant. Accessed 22 Nov. 2024.
Ibrahim, Latifat, and Dr. K. . "Neuroprotective Effect of Croton Zambesicus Phenolic Extract on Synaptosomes of Rats Exposed to Environmental Toxicant". Afribary, Afribary, 07 May. 2018. Web. 22 Nov. 2024. < https://afribary.com/works/neuroprotective-effect-of-croton-zambesicus-phenolic-extract-on-synaptosomes-of-rats-exposed-to-environmental-toxicant >.
Ibrahim, Latifat and K., Dr. . "Neuroprotective Effect of Croton Zambesicus Phenolic Extract on Synaptosomes of Rats Exposed to Environmental Toxicant" Afribary (2018). Accessed November 22, 2024. https://afribary.com/works/neuroprotective-effect-of-croton-zambesicus-phenolic-extract-on-synaptosomes-of-rats-exposed-to-environmental-toxicant