Abstract
Background: Release-retarding polymers in matrix tablets play a vital role in controlling drug release from tablets. Objectives: To prepare metoprolol succinate tablets by direct compression using Ofada rice (Oryza glaberrima Steud) starch acetate, degree of substitution (DS) 2.22, as a matrix for sustained release. Materials and methods: The central composite design and response surface methodology were applied to evaluate the interactive effects of three variables: percent content of starch acetate (X1), compression pressure (X2) and compression time (X3), on tablet crushing strength, friability and dissolution time (t80). Results: Crushing strength was 90.0 to 140.50 N; Friability 0.05 to 0.90 % and t80 5.75 to 11.50 h. X1 and X2 had significant effects on crushing strength and dissolution time (p < 0.0001). The interactions between X1 and X2 and those between X1 and X3 were significant on crushing strength and dissolution time, and on friability respectively (p < 0.0001). The correlation coefficients indicated that the regression model represented the experimental data well (R2 = 0.9971 and R2 (Adj) = 0.9944 for crushing strength; R2 = 0.9976 and R2 (Adj) = 0.9954 for friability; R2 = 0.9979 and R2 (Adj) = 0.9961 for t80). Optimized conditions for formulation of metoprolol succinate tablets were 60 %w/w Ofada starch acetate; 150 MNm-2 compression pressure and 60 s compression time. Conclusion: Optimized formulations of metoprolol tablets containing Ofada starch acetate with good mechanical strength and prolonged dissolution can be obtained when process conditions are adjusted within the reported values.
Okunlola, A (2021). Optimization of Formulations of Metoprolol Succinate Tablets Containing Ofada Rice Starch Acetate as Tablet Matrix for Sustained Release Using Response Surface Methodology. Afribary. Retrieved from https://afribary.com/works/optimization-of-formulations-of-metoprolol-succinate-tablets-containing-ofada-rice-starch-acetate-as-tablet-matrix-for-sustained-release-using-response-surface-methodology
Okunlola, Adenike "Optimization of Formulations of Metoprolol Succinate Tablets Containing Ofada Rice Starch Acetate as Tablet Matrix for Sustained Release Using Response Surface Methodology" Afribary. Afribary, 14 May. 2021, https://afribary.com/works/optimization-of-formulations-of-metoprolol-succinate-tablets-containing-ofada-rice-starch-acetate-as-tablet-matrix-for-sustained-release-using-response-surface-methodology. Accessed 25 Apr. 2024.
Okunlola, Adenike . "Optimization of Formulations of Metoprolol Succinate Tablets Containing Ofada Rice Starch Acetate as Tablet Matrix for Sustained Release Using Response Surface Methodology". Afribary, Afribary, 14 May. 2021. Web. 25 Apr. 2024. < https://afribary.com/works/optimization-of-formulations-of-metoprolol-succinate-tablets-containing-ofada-rice-starch-acetate-as-tablet-matrix-for-sustained-release-using-response-surface-methodology >.
Okunlola, Adenike . "Optimization of Formulations of Metoprolol Succinate Tablets Containing Ofada Rice Starch Acetate as Tablet Matrix for Sustained Release Using Response Surface Methodology" Afribary (2021). Accessed April 25, 2024. https://afribary.com/works/optimization-of-formulations-of-metoprolol-succinate-tablets-containing-ofada-rice-starch-acetate-as-tablet-matrix-for-sustained-release-using-response-surface-methodology