PARAOXONASE 1 (PON 1) Q192R GENOTYPE DISTRIBUTION IN GHANAIANS WITH TYPE II DIABETES MELLITUS

ABSRACT

Background: Recent studies have indicated PON 1 polymorphism to be associated with cardiovascular-related diseases such as diabetes mellitus but varied reports have been provided from such association studies. In Ghana, there is no such information on PON 1 polymorphism in disease situations; except one instance reported in non-diseased Ghanaians. The present study has therefore provided baseline information on PON 1 Q192R polymorphism in Ghanaians with type II Diabetes Mellitus.

Main Objective: To determine the PON 1 Q192R genotypes in Ghanaian type II diabetes mellitus patients and its impact on clinical variables

Design: The study was located at the National Diabetes Management and Research Centre (NDMRC), Korle Bu Teaching Hospital, Accra. Subjects were recruited consecutively at the outpatients’ clinic of the NDMRC; and interrogated through a questionnaire for demographic and clinical information. Fasting blood samples were collected from 112 Type II diabetes mellitus patients and 97 non-diabetic control participants. The fasting plasma glucose and lipid profiles were measured. DNA extracted from the diabetic and control buffy–coat samples was used in determining the PON 1 Q192R polymorphism, by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) analysis.

Results: The R allele was strongly associated with diabetes mellitus. All three PON 1 Q192R genotypes (QQ, RR, and QR) were present in Ghanaians with corresponding frequencies in Type II diabetic population being 18.18%, 74.55%, 7.27% and 33.33%, 57.14%, 9.52% in the control group respectively (χ2 = 3.432, p = 0.1798). The type II diabetics in all the PON 1 Q192R genotype groups recorded significantly higher TG and VLDL levels (p < 0.05).

Conclusion: The RR genotype was the most frequent in the populations studied, whereas the QR genotype was the least frequent. The R allele was significantly associated with type II diabetes mellitus. PON 1 Q192R RR and QQ genotypes were associated with high FPG levels in the diabetics.

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APA

MUHYIA, D (2021). PARAOXONASE 1 (PON 1) Q192R GENOTYPE DISTRIBUTION IN GHANAIANS WITH TYPE II DIABETES MELLITUS. Afribary. Retrieved from https://afribary.com/works/paraoxonase-1-pon-1-q192r-genotype-distribution-in-ghanaians-with-type-ii-diabetes-mellitus

MLA 8th

MUHYIA, DORCAS "PARAOXONASE 1 (PON 1) Q192R GENOTYPE DISTRIBUTION IN GHANAIANS WITH TYPE II DIABETES MELLITUS" Afribary. Afribary, 31 Mar. 2021, https://afribary.com/works/paraoxonase-1-pon-1-q192r-genotype-distribution-in-ghanaians-with-type-ii-diabetes-mellitus. Accessed 13 Jun. 2024.

MLA7

MUHYIA, DORCAS . "PARAOXONASE 1 (PON 1) Q192R GENOTYPE DISTRIBUTION IN GHANAIANS WITH TYPE II DIABETES MELLITUS". Afribary, Afribary, 31 Mar. 2021. Web. 13 Jun. 2024. < https://afribary.com/works/paraoxonase-1-pon-1-q192r-genotype-distribution-in-ghanaians-with-type-ii-diabetes-mellitus >.

Chicago

MUHYIA, DORCAS . "PARAOXONASE 1 (PON 1) Q192R GENOTYPE DISTRIBUTION IN GHANAIANS WITH TYPE II DIABETES MELLITUS" Afribary (2021). Accessed June 13, 2024. https://afribary.com/works/paraoxonase-1-pon-1-q192r-genotype-distribution-in-ghanaians-with-type-ii-diabetes-mellitus