So far, majority of the preventive effect of
prebiotics has been on animal models. However, several in vitro studies using
2D and 3D cell cultures mimicking the environmental condition as well as
various organisms present within the gut of man had shown the efficacy of
prebiotics in reducing the attachment of enteropathogenic organisms like S. typhi to the gut epithelium. In vivo
studies with human have been able to prove its efficacy in preventing diseases
such as Inflammatory bowel disease, traveler’s diarrhea and colitis. Despite
little or no in vivo studies in man as to the effectiveness of prebiotics in combating S. typhi, it is not withstanding still a promising concept as
several in vitro studies had shown its efficacy. Furthermore, the lack of
mutagenicity and genotoxicity of prebiotics as well as a few side effects
(diarrhea, gas and bloating) resulting from overdose makes it even more
promising as a preventive medicine. Moreover they are known to boost immune
functions of the gut thereby increasing the natural resistance of the host to
pathogens without altering the normal flora of the gut.
Hammed, B (2019). Prebiotics-a viable prophylaxis against Salmonella typhii. Afribary.com: Retrieved May 29, 2020, from https://afribary.com/works/prebiotics-a-viable-prophylaxis-against-salmonella-typhii
Bukola, Hammed. "Prebiotics-a viable prophylaxis against Salmonella typhii" Afribary.com. Afribary.com, 11 May. 2019, https://afribary.com/works/prebiotics-a-viable-prophylaxis-against-salmonella-typhii . Accessed 29 May. 2020.
Bukola, Hammed. "Prebiotics-a viable prophylaxis against Salmonella typhii". Afribary.com, Afribary.com, 11 May. 2019. Web. 29 May. 2020. < https://afribary.com/works/prebiotics-a-viable-prophylaxis-against-salmonella-typhii >.
Bukola, Hammed. "Prebiotics-a viable prophylaxis against Salmonella typhii" Afribary.com (2019). Accessed May 29, 2020. https://afribary.com/works/prebiotics-a-viable-prophylaxis-against-salmonella-typhii