The potential protective effects of Diphenyl-diselenide (PhSe)2 on Mercuric chloride-Induced Nephrotoxicity in female wistar rats

ABSTRACT

Evidences have implicated free radicals or reactive oxygen species in mercuric chloride-induced nephrotoxicity. Diphenyl diselenide (PhSe)2, a simple and stable organoselenium compound, has been proposed as a good candidate for pharmacological and therapeutic purposes. This particular study was designed to investigate the protective effect of (PhSe)2 against mercuric chloride-induced nephrotoxicity.

In this study, 44 female Wistar rats with weights ranging from 125g and 180g were randomly divided into 5 groups. Control rats in groups 1 and 2 were administered normal saline and/or corn oil. Group 3 animals were treated with (PhSe)2 alone while those in Groups 4 and 5 were challenged with HgCl2. Group 5 rats were additionally co-treated with (PhSe)2. Mercuric chloride and (PhSe)2 were given orally at a specific dose of 5 mg/kg/day. Integrity of kidney was assessed by urea and creatinine levels and oxidative stress indices were also determined. Results were analysed using analysis of variance (ANOVA) with significance level set at p

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APA

Amodu, K. (2019). The potential protective effects of Diphenyl-diselenide (PhSe)2 on Mercuric chloride-Induced Nephrotoxicity in female wistar rats. Afribary. Retrieved from https://afribary.com/works/project-quadri-fin-2

MLA 8th

Amodu, Kolawole "The potential protective effects of Diphenyl-diselenide (PhSe)2 on Mercuric chloride-Induced Nephrotoxicity in female wistar rats" Afribary. Afribary, 05 Jun. 2019, https://afribary.com/works/project-quadri-fin-2. Accessed 19 Apr. 2024.

MLA7

Amodu, Kolawole . "The potential protective effects of Diphenyl-diselenide (PhSe)2 on Mercuric chloride-Induced Nephrotoxicity in female wistar rats". Afribary, Afribary, 05 Jun. 2019. Web. 19 Apr. 2024. < https://afribary.com/works/project-quadri-fin-2 >.

Chicago

Amodu, Kolawole . "The potential protective effects of Diphenyl-diselenide (PhSe)2 on Mercuric chloride-Induced Nephrotoxicity in female wistar rats" Afribary (2019). Accessed April 19, 2024. https://afribary.com/works/project-quadri-fin-2

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The potential protective effects of Diphenyl-diselenide (PhSe)2 on Mercuric chloride-Induced Nephrotoxicity in female wistar rats

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