ABSTRACT
The extracts of many plants used in traditional medicine in Africa have been shown to contain therapeutic agents supporting their use in the treatment and management of many disease endemic to the region. Trypanosomiasis (sleeping sickness) is one of such diseases that still are a major health challenge in sub-Saharan Africa, in the quest to combat this problem, the search for trypanocidal agents from medicinal plants has arisen. The aim of this study was to investigate and corroborate the claim in traditional medicine of the safety and efficacy of the extract of Mitragyna ciliata Aubrev and Pellege (Rubiascae) in the treatment of trypanosomiasis. The study started with initial screening hydroethanolic extracts of the roots of two plants- Mitragyna ciliata Aubrev. & Pellegr. (Rubiaceae) and Ritches longipedicellata Gilg- (Capparidaceae), for toxicity and antitrypanosomal activity, Toxicity test result after single dose administration of extracts to rats for 21 days, show that both plant extracts exhibited a marked decrease in ALP, ALT, AST and creatinine levels (p
ARITETSOMA, O (2021). The Biochemical Studies Of Trypanocidal Activity Of Mitragyna Ciliate Aubrev & Pellegr. (Rubiaceae). Afribary. Retrieved from https://afribary.com/works/the-biochemical-studies-of-trypanocidal-activity-of-mitragyna-ciliate-aubrev-pellegr-rubiaceae
ARITETSOMA, OGBUNUGAFOR "The Biochemical Studies Of Trypanocidal Activity Of Mitragyna Ciliate Aubrev & Pellegr. (Rubiaceae)" Afribary. Afribary, 06 May. 2021, https://afribary.com/works/the-biochemical-studies-of-trypanocidal-activity-of-mitragyna-ciliate-aubrev-pellegr-rubiaceae. Accessed 13 May. 2024.
ARITETSOMA, OGBUNUGAFOR . "The Biochemical Studies Of Trypanocidal Activity Of Mitragyna Ciliate Aubrev & Pellegr. (Rubiaceae)". Afribary, Afribary, 06 May. 2021. Web. 13 May. 2024. < https://afribary.com/works/the-biochemical-studies-of-trypanocidal-activity-of-mitragyna-ciliate-aubrev-pellegr-rubiaceae >.
ARITETSOMA, OGBUNUGAFOR . "The Biochemical Studies Of Trypanocidal Activity Of Mitragyna Ciliate Aubrev & Pellegr. (Rubiaceae)" Afribary (2021). Accessed May 13, 2024. https://afribary.com/works/the-biochemical-studies-of-trypanocidal-activity-of-mitragyna-ciliate-aubrev-pellegr-rubiaceae