ABSTRACT
A central pathogenic feature in Plasmodium falciparum cerebral malaria (CM) is the sequestration of infected erythrocytes (IEs) which results in the obstruction of blood flow, inflammation and damage to the endothelial cell barrier integrity. Adhesion is mediated by a family of approximately 60 highly variant parasite proteins called P. falciparum erythrocyte membrane protein 1 (PfEMP1), which are displayed on the surface of infected cells. All PfEMP1 contain multiple extracellular domains of Duffy binding like (DBL) and cysteine-rich interdomain region (CIDR) proteins that mediate adhesion to various host endothelial receptors such as intercellular adhesion molecule 1 (ICAM-1). An important unanswered question in malaria pathogenesis has always been whether a specific binding phenotype can be linked to any of the different severe malaria phenotypes. The broad objectives of this study were to investigate the involvement of an ICAM-1 binding motif in PfEMP1 in the development of CM, as well as to evaluate the contributions of the immune response and other determinants driving severe malaria complications.
ECKLU-MENSAH, G (2021). The Role Of An Intercellular Adhesion Molecule 1 Binding Motif In Plasmodium Falciparum Erythrocyte Membrane Protein 1 And Other Determinants Involved In Severe Malaria Pathogenesis. Afribary. Retrieved from https://afribary.com/works/the-role-of-an-intercellular-adhesion-molecule-1-binding-motif-in-plasmodium-falciparum-erythrocyte-membrane-protein-1-and-other-determinants-involved-in-severe-malaria-pathogenesis
ECKLU-MENSAH, GERTRUDE "The Role Of An Intercellular Adhesion Molecule 1 Binding Motif In Plasmodium Falciparum Erythrocyte Membrane Protein 1 And Other Determinants Involved In Severe Malaria Pathogenesis" Afribary. Afribary, 28 Apr. 2021, https://afribary.com/works/the-role-of-an-intercellular-adhesion-molecule-1-binding-motif-in-plasmodium-falciparum-erythrocyte-membrane-protein-1-and-other-determinants-involved-in-severe-malaria-pathogenesis. Accessed 17 May. 2024.
ECKLU-MENSAH, GERTRUDE . "The Role Of An Intercellular Adhesion Molecule 1 Binding Motif In Plasmodium Falciparum Erythrocyte Membrane Protein 1 And Other Determinants Involved In Severe Malaria Pathogenesis". Afribary, Afribary, 28 Apr. 2021. Web. 17 May. 2024. < https://afribary.com/works/the-role-of-an-intercellular-adhesion-molecule-1-binding-motif-in-plasmodium-falciparum-erythrocyte-membrane-protein-1-and-other-determinants-involved-in-severe-malaria-pathogenesis >.
ECKLU-MENSAH, GERTRUDE . "The Role Of An Intercellular Adhesion Molecule 1 Binding Motif In Plasmodium Falciparum Erythrocyte Membrane Protein 1 And Other Determinants Involved In Severe Malaria Pathogenesis" Afribary (2021). Accessed May 17, 2024. https://afribary.com/works/the-role-of-an-intercellular-adhesion-molecule-1-binding-motif-in-plasmodium-falciparum-erythrocyte-membrane-protein-1-and-other-determinants-involved-in-severe-malaria-pathogenesis