ABSTRACT Cancer they say is the chief of all maladies, following cardiovascular disease, cancer is the second leading cause of death in most affluent countries. There are about 13.3 million new cases of cancer in 2010 which is predicted to cost US$ 290 billion, but the total costs is expected to increases to US$ 458 billion in the year 2030 on basis of World Economic Forum in 2011. More than half of all cancer cases and deaths worldwide are considered preve...
THE GENETICS OF ABC TRANSPORTER1.0 INTRODUCTIONThe transport of organic and inorganic molecules across cellular membranes is vital to allforms of life, as it allows cells to maintain an off equilibrium condition. In Escherichia coli,for example, ~10% of the entire genome is dedicated to membrane-bound and solubleproteins involved in transport processes (Blattner et al., 1997). On the timescale relevant forcellular metabolism, the lipid bilayer rep...
ABSTRACT The present study investigated the ameliorative properties of Diospyroschloroxylon (methanolic) leaf extract (DCLE) in liver of rats intoxicated with N-Nitrosodimethylamine (NDMA). Antioxidant markers- Superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and lipid peroxidation were assayed spectrophotometrically. DNA fragmentation was determined spectrophotometrically. The Bcl-2, Ki-67 and ...
ABSTRACT Targeting apoptosisisan attractive approach in cancertherapy. Induction of apoptosis can be carried out by the BH3-only proteins of the BCL-2 family(having only the BCL-2 homology domain BH3) by binding to the pro-survival members and neutralizing their functional activity (sequestration of the pro-apoptotic Bcl-2 family members). In this review, brief summary of the current models of Bcl-2 family function and the work demonstrating the influence of deregulated Bcl-2 family member ex...
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