ABSTRACT
The present study investigated the ameliorative properties of Diospyroschloroxylon (methanolic) leaf extract (DCLE) in liver of rats intoxicated with N-Nitrosodimethylamine (NDMA). Antioxidant markers- Superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and lipid peroxidation were assayed spectrophotometrically.
DNA fragmentation was determined spectrophotometrically. The Bcl-2, Ki-67 and CD15 markers were assayed using immunohistochemistry. The activities of SOD and catalase were decreased in the NDMA-treated rats by 99.5% and 47.1%, respectively compared with controls, whereas pretreatment with DCLE showed significantly elevated (p < 0.05) values as against NDMA. NDMA treatment reduced GSH level by 35.7% compared with controls, while DCLE pretreatment significantly increased the level relative to NDMA group. The NDMA significantly increased (p
Olagunju, A. (2018). Hepatoprotective Effect of Methanol Extract of Diospyroschloroxylon Leaf in N-Nitrosodimethylamine-induced hepatotoxicity in rats. Afribary. Retrieved from https://afribary.com/works/22-hepatoprotective-effect-of-methanol-extract-of-diospyroschloroxylon-leafity-in-rats
Olagunju, Abolaji "Hepatoprotective Effect of Methanol Extract of Diospyroschloroxylon Leaf in N-Nitrosodimethylamine-induced hepatotoxicity in rats" Afribary. Afribary, 12 Mar. 2018, https://afribary.com/works/22-hepatoprotective-effect-of-methanol-extract-of-diospyroschloroxylon-leafity-in-rats. Accessed 22 Dec. 2024.
Olagunju, Abolaji . "Hepatoprotective Effect of Methanol Extract of Diospyroschloroxylon Leaf in N-Nitrosodimethylamine-induced hepatotoxicity in rats". Afribary, Afribary, 12 Mar. 2018. Web. 22 Dec. 2024. < https://afribary.com/works/22-hepatoprotective-effect-of-methanol-extract-of-diospyroschloroxylon-leafity-in-rats >.
Olagunju, Abolaji . "Hepatoprotective Effect of Methanol Extract of Diospyroschloroxylon Leaf in N-Nitrosodimethylamine-induced hepatotoxicity in rats" Afribary (2018). Accessed December 22, 2024. https://afribary.com/works/22-hepatoprotective-effect-of-methanol-extract-of-diospyroschloroxylon-leafity-in-rats