Ginger or Zingiber officinale has been reported to possess antioxidant activities that can protect against free radical damage. We therefore carried out this study to investigate the possible ameliorative effects of ginger against the clastogenicity, hepatotoxicity and oxidative stress induced by nitrobenzene (NB) administration in wistar rats. Twenty male wistar rats were divided into four groups: group I (normal control group), fed with normal rat chow and clean drinking water only for seven days; group II, fed with 1000 mg/kg NB only for two days; group III, fed with 1000 mg/kg NB for two days, followed by treatment with 400 mg/kg Z. officinale ethanolic extract for seven days; and group IV, to which 400 mg/kg Z. officinale extract were administered only for seven days. The whole experiment lasted for seven days and animals were sacrificed 24 hours after the last dose to obtain the blood for plasma preparation. The following parameters were then determined: oxidative stress markers (catalase activity and extent of lipid peroxidation), hepatic function indices (aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and total bilirubin (TB). Total protein (TP) and lipid profile parameters – total cholesterol (TC) and triglyceride (TG) – were also measured. Femurs were harvested from the rats for micronucleus assay (clastogenicity) too. Comparing the normal control group with the NB only group, there was a significant increase (p
Somade, O. (2018). ANTICLASTOGENIC AND HEPATOPROTECTIVE PROPERTIES OF GINGER (ZINGIBER OFFICINALE) EXTRACT AGAINST NITROBENZENE-INDUCED TOXICITY IN RATS. Afribary. Retrieved from https://afribary.com/works/anticlastogenic-and-hepatoprotective-properties-of-ginger-zingiber-officinale-extract-against-nitrobenzene-induced-toxicity-in-rats
Somade, Oluwatobi "ANTICLASTOGENIC AND HEPATOPROTECTIVE PROPERTIES OF GINGER (ZINGIBER OFFICINALE) EXTRACT AGAINST NITROBENZENE-INDUCED TOXICITY IN RATS" Afribary. Afribary, 26 Mar. 2018, https://afribary.com/works/anticlastogenic-and-hepatoprotective-properties-of-ginger-zingiber-officinale-extract-against-nitrobenzene-induced-toxicity-in-rats. Accessed 11 Oct. 2024.
Somade, Oluwatobi . "ANTICLASTOGENIC AND HEPATOPROTECTIVE PROPERTIES OF GINGER (ZINGIBER OFFICINALE) EXTRACT AGAINST NITROBENZENE-INDUCED TOXICITY IN RATS". Afribary, Afribary, 26 Mar. 2018. Web. 11 Oct. 2024. < https://afribary.com/works/anticlastogenic-and-hepatoprotective-properties-of-ginger-zingiber-officinale-extract-against-nitrobenzene-induced-toxicity-in-rats >.
Somade, Oluwatobi . "ANTICLASTOGENIC AND HEPATOPROTECTIVE PROPERTIES OF GINGER (ZINGIBER OFFICINALE) EXTRACT AGAINST NITROBENZENE-INDUCED TOXICITY IN RATS" Afribary (2018). Accessed October 11, 2024. https://afribary.com/works/anticlastogenic-and-hepatoprotective-properties-of-ginger-zingiber-officinale-extract-against-nitrobenzene-induced-toxicity-in-rats