Pharmacology Research Papers/Topics

A Randomized Trial to Monitor the Efficacy and Effectiveness by QT-NASBA of Artemether-lumefantrine versus Dihydroartemisinin-piperaquine for Treatment and Transmission Control of Uncomplicat

Abstract: Background: Many countries have implemented artemisinin-based combination therapy (ACT) for the first-line treatment of malaria. Although many studies have been performed on efficacy and tolerability of the combination arthemeter-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP), less is known of the effect of these drugs on gametocyte development, which is an important issue in malaria control. Methods and results: In this two-arm randomized controlled trial, 146 children ...

Efficacy of Single-Dose Primaquine With Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis

Abstract: Background. Since the World Health Organization recommended single low-dose (0.25 mg/kg) primaquine (PQ) in combination with artemisinin-based combination therapies (ACTs) in areas of low transmission or artemisinin-resistant Plasmodium falciparum, several single-site studies have been conducted to assess efficacy. Methods. An individual patient meta-analysis to assess gametocytocidal and transmission-blocking efficacy of PQ in combination with different ACTs was conducted. Random ...

The effects of crude propolis, its volatiles andethanolic extracts on the ecto-parasitic mite,Varroa destructorand health of the Africansavannah honey bee,Apis mellifera scutellata

Abstract: Propolis is a hive product composed of biologically active plant resins, and has been shown toenhance individual honey bee (Apis melliferaL.) health. Propolis has also been demonstratedto mitigate, in part, the negative effects caused by the ecto-parasitic miteVarroa destructorand its associated viruses on the health of managed European honey bee colonies.However, its effect on the health status of African honey bees remains largely unknown.Here, we found that the African savannah ...

PHARMACOGNOSTIC INVESTIGATION, ISOLATION, CHARACTERIZATION AND CONFIRMATION OF THE STRUCTURE OF PHENACETINE EXTRACTED FROM THE DRIED POWDERED LEAVES OF TRADITIONAL MEDICINAL PLANT ALLOPHYLUS

Abstract Pharmacognostic investigation involving organoleptic evaluation, fluorescent analysis, phytochemical screening and mineral analysis was carried out on the dried powdered leaves of Allophylus africanus used for treating pain, headaches, common cold, Fever and as antibiotics in Eastern Province of Sierra Leone. The powdered leaves were light brown in colour with woody odour, bitter taste and gave significant fluorescent derivatives with the reagents 1M NaOH (aq), 1M NaOH(alc.), Ammonia...

PHYTOCHEMICAL SCREENING AND IN VIVO ANTIMALARIAL ACTIVITY OF THE METHANOL LEAF EXTRACT OF TAPINANTHUS DODONEIFOLIUS (DC) DANSER GROWING ON VITEX DONIANA

Malaria is a major public health problem in the world especially in Africa, with an estimated two million  children and pregnant women worldwide dying of malaria yearly, primarily because of Plasmodium  falciparum and its complications. Preliminary phytochemical screening of the methanol leaf extract revealed the presence of triterpenoids, saponins, tannins, terpenoids, flavonoid, cardiac glycoside,  carbohydrate and alkaloids. The in vivo antimalarial activity of the crude methanol leaf ...

Evidence for the Immune Toxicity of Green Tea Polyphenols: A Computational Study

Adverse drug reactions (ADR) triggered by a drug or its metabolites is an essential aspect of the post-clinical phase in the drug discovery pipeline. The pathophysiology of ADRs has been described in two ways; expected and idiosyncratic. In the current study, we deployed valid computational tools to predict the ability of eight green tea polyphenols to favourably interact with HLA-B*57:01 and mediate idiosyncratic ADRs. First, we deployed molecular docking to understand the free energy profil...