Research Papers/Topics in Pharmacology

PHARMACOGNOSTIC INVESTIGATION, ISOLATION, CHARACTERIZATION AND CONFIRMATION OF THE STRUCTURE OF PHENACETINE EXTRACTED FROM THE DRIED POWDERED LEAVES OF TRADITIONAL MEDICINAL PLANT ALLOPHYLUS

AbstractPharmacognostic investigation involving organoleptic evaluation, fluorescent analysis, phytochemical screening and mineral analysis was carried out on the dried powdered leaves of Allophylus africanus used for treating pain, headaches, common cold, Fever and as antibiotics in Eastern Province of Sierra Leone. The powdered leaves were light brown in colour with woody odour, bitter taste and gave significant fluorescent derivatives with the reagents 1M NaOH (aq), 1M NaOH(alc.), Ammonia,...

PHYTOCHEMICAL SCREENING AND IN VIVO ANTIMALARIAL ACTIVITY OF THE METHANOL LEAF EXTRACT OF TAPINANTHUS DODONEIFOLIUS (DC) DANSER GROWING ON VITEX DONIANA

Malaria is a major public health problem in the world especially in Africa, with an estimated two million children and pregnant women worldwide dying of malaria yearly, primarily because of Plasmodium falciparum and its complications. Preliminary phytochemical screening of the methanol leaf extract revealed the presence of triterpenoids, saponins, tannins, terpenoids, flavonoid, cardiac glycoside, carbohydrate and alkaloids. The in vivo antimalarial activity of the crude methanol leaf ext...

Evidence for the Immune Toxicity of Green Tea Polyphenols: A Computational Study

Adverse drug reactions (ADR) triggered by a drug or its metabolites is an essential aspect of the post-clinical phase in the drug discovery pipeline. The pathophysiology of ADRs has been described in two ways; expected and idiosyncratic. In the current study, we deployed valid computational tools to predict the ability of eight green tea polyphenols to favourably interact with HLA-B*57:01 and mediate idiosyncratic ADRs. First, we deployed molecular docking to understand the free energy profil...