Research Papers/Topics in Pharmacology

Effects of Crude Aqueous Leaf Extracts of Citropsis Articulata and Mystroxylon Aethiopicum on Sex Hormone Levels In Male Albino Rats

ABSTRACT: The study evaluated effect of aqueous leaf extracts of C. articulata and M. aethiopicum on serum levels of testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin in male albino rats as well as on organ weights and histological structure of the testis. The phytochemical composition of the extracts was also qualitatively determined. This was an experimental study. Shade dried C. articulata and M. aethiopicum leaves were pounded and crude extracts were...

THE CONTRIBUTIONS OF PRESYNAPTIC ALPHA-2 (α2) RECEPTORS AND PROSTAGLANDIN E-SERIES TO THE CONTROL OF SYMPATHETIC NERVOUS ACTIVITY.

      ABSTRACTThe Sympathetic nervous systems (SNS) is an efferent division of the Autonomic nervous system (ANS) with neurons which anatomically originates in the central nervous system (CNS). It has a short preganglionic neuron which comes from the thoracic and lumbar regions (T1 to L2) (also termed, thoracolumbar outflow) of the spinal cord. The axons of the postganglionic neuron extend from these ganglia to the tissues that ...

Drug Abuse

'Drug abuse' is no longer a current medical diagnosis in either of the most used diagnostic tools in the world, the American Psychiatric Association's Diagnosticand Statistical Manual of Mental Disorders (DSM), and the World Health Organization's International Statistical Classification of Diseases and ICRIS Medical organization Related Health Problems (ICD) Substance abuse has been adopted by the DSM as a blanket term to include drug abuse and other things, while the...

EFFECT OF LISINOPRIL AN ANGIOTENSIN CONVERTING ENZYME(ACE) INHIBITOR ON SPERMATOGENESIS IN RATS

OVERVIEWThe role of ACE inhibitors (Lisinopril) in reproductive function remains controversial. Some benefits seem to be derivable even in non-hypertensive males with low doses. This study was done using rat model to establish this fact. Male rats were divided into different groups to receive different doses of lisinopril. A control group received no drugs. The mean arterial pressure fell the most with 5mg of lisinopril. The greatest increase in sperm count and motility was recorded for this ...