Research Papers/Topics in Pharmacology

Anti-Hyperglycaemic And Anti-Oxidant Effect Of Synedrella Nodiflora (L) Gaertn In Streptozotocin-Induced Diabetes In Rats..

ABSTRACT Background: Synedrella nodiflora is a common weed in Ghana that is boiled to treat epilepsy and threatened abortion. The ethanolic whole plant extract has been demonstrated to have antiinflammatory, antioxidant, hypoglycemic, anticonvulsant, sedative, antidepressant and antipsychotic effects in murine models. The study presents the anti-oxidant and antihyperglycaemic effects of the ethanolic extract of the whole plant extract of Synedrella nodiflora (SNE) on a diabetic rat m...

Genotypic Frequencies Of Cyp2b6, Cyp3a5 And Sult1a1 Polymorphism Among HIV Patients ON Nevirapine-Based Antiretroviral Therapy At The Korle-Bu Teaching Hospital

ABSTRACT Background: A major constraint in the management of People Living with Human Immunodeficiency Virus, with highly active antiretroviral therapy is the high incidence of adverse drug reaction among patients. Nevirapine, a non-nucleoside reverse transcriptase inhibitor is among the first-line antiretroviral therapy used in Ghana for the management of Human immunodeficiency virus-1 patients. Despite its usefulness, hypersensitivity reaction is a common complication that accou...

Pharmacological Evaluation of Anti-Inflammatory Activity of Aqueous Extract of The Root Bark of Capparis Erythrocapos

ABSTRACT Background: Capparis erythrocarpos is a medicinal plant that is used extensively in folklore medicine in Ghana to manage various inflammatory conditions. Previous pharmacological study showed that an ethanolic extract of the roots of Capparis erythrocarpos may have antiinflammatory activity. However, no attempt has been made to investigate the basis of the effect(s), if any, of the aqueous extract on the inflammatory processes or ascertain its safety. Aim: The aim of this study ...

Studies On The Antivenom Activities Of The Aqueous Extracts Of Paullinia Pinnata And Detarium Microcarpum Against Echis Carinatus (Carpet Viper) Venom

ABSTRACTIn rural savannah areas of Nigeria, Echics ocellatus (Carpet viper) is responsible for high incidence of snakebite morbidity and mortality. The snakebites are commonly treated with plant extracts in form of traditional medicine. The antivenom activity of Paullinia pinnata Linn and Detarium microcarpum Guill and Perr, popular herbs used in the treatment of Echis ocellatus bites are of great interest and were investigated in vivo and in vitro against the venom (2mg/kg) of Echis carniatu...

Analgesic Effects Of Synedrella Nodiflora (L) Gaertn Whole Plant Extract In Streptozotocin- Induced Diabetic Neuropathy In Rats.

ABSTRACTBackground: The ethanolic extract of Synedrella nodiflora has demonstrated analgesic activity in acute and chemotherapy-induced neuropathic pain in rodents. The present study evaluates the analgesic effect in hyperalgesia and allodynia associated with streptozotocin–induced diabetic neuropathy in rats and also elucidates the antioxidant activity of the extract.Method: Diabetic neuropathy was induced by intraperitoneal injection with 55 mg/kg freshly prepared streptozotocin (STZ) dis...

Ethnopharmalogical And Phytochemical Properties of Some Plants Used in The Management of Pain

ABSTRACT Pain is a worldwide problem and is associated with most disease conditions. The properties of herbs used to treat pain were investigated with the aim of confirming their use and finding out some pharmacological properties that may augment their analgesic activity. A total of eighteen plants (Erythrina senegalesis, Nauclea latifollia, Kizelia africana, Pseudocedrela kotchyi, Crotalaris spp., Boswellia dalzielli, Khaya senegalensis, Annona senegalensis, Xylopia aethiopica, Ficus...

AntiConvulsant And Sedative Effects Of The Hydro-Ethanolic Whole Plant Extraction Of Cleome Ruicetidosperma (DC.) (CLEOMECEAE) In Mice.

ABSTRACT BACKGROUND:Cleome rutidosperma (DC.) (Family: Cleomeceae) is a low-growing herb used for the treatment of epilepsy in African traditional medicine. This study presents the anticonvulsant, sedative effects and safety profile of the hydro-ethanolic extract of the whole plant of Cleome rutidosperma (CRE) in murine experimental models. METHODS: Preliminary phytochemical screening of the extract was conducted using standard colorimetric assays. The general effect of the extrac...

A Study Of Metformin Versus Insulin In The Management Of Diabetes Mellitus In Pregnancy At The Korle Bu Teaching Hospital

ABSTRACT Background: Diabetes mellitus is an important complication of pregnancy with adverse effects on both mother and fetus. Poor control of pre-gestational diabetes during the period of organogenesis increases the risk of major congenital malformations. While insulin is effective in controlling high blood glucose levels, otherwise resistant to diet and exercise management, several factors hinder its use. Metformin has been found to be a convenient, cheap, effective and safe hypoglyc...

Effect Of An Ethanolic Fruit Extract Of Xylopia Aethiopica And Its Kaurene Diterpenoid, Xylopic Acid, On Learning And Memory: A Pre-Clinical Evaluation From A Neuropharmacological Perspective

ABSTRACT Background: Cognitive dysfunction, presenting as learning and memory impairment, is a common manifestation in many chronic diseases, including depression, epilepsy and Alzheimer’s disease. It could also be present without any known underlying medical condition. Till date, no drug has shown convincing efficacy in improving learning and memory deficits in these conditions although some medicinal plants are demonstrating promising effects. The aim of the study was to investigate...

Effect Of Cellgevity®, A Glutathione-Enhancer Dietary Supplement, On Streptozotocin-Induced Type-2 Diabetes And Nephrotoxicity In Rat

ABSTRACT Background: Diabetic nephropathy (DN), a diabetes-induced nerve damaging effect on the kidney structure and function due to hyperglycaemia is a major microvascular complication. Hyperglycaemia causes uremia, hypercreatininemia, declined glomerular filtration rate, and decreased levels of serum protein and albumin. This condition leads to progressive decline in renal function resulting in renal insufficiency and End-Stage Renal Disease. The prevalence of DN in Africa has increas...

Amikacin Treatment With or Without Aminophyllibe in Neonates With Suspected Sepsis at Korle-BU Teaching Hospital: A Pharmacokinetic and and Pharmacodynamic Study

ABSTRACT Background: Sepsis is a major cause of death among neonates. In neonates, symptoms of sepsis are often non-specific and diagnosis requires a high index of suspicion. Thus, the role of additional diagnostic markers is important. Amikacin is used as first-line treatment of neonatal sepsis and it is usually co-administered with aminophylline in preterm neonates in Ghana. Amikacin dosing is well established, however, optimal effect requires specific dose titration and maintenance t...

STUDIES ON THE ANTIVENOM ACTIVITIES OF THE AQUEOUS EXTRACTS OF PAULLINIA PINNATA AND DETARIUM MICROCARPUM AGAINST ECHIS CARINATUS (CARPET VIPER) VENOM

In rural savannah areas of Nigeria, Echics ocellatus (Carpet viper) is responsible for high incidence of snakebite morbidity and mortality. The snakebites are commonly treated with plant extracts in form of traditional medicine. The antivenom activity of Paullinia pinnata Linn and Detarium microcarpum Guill and Perr, popular herbs used in the treatment of Echis ocellatus bites are of great interest and were investigated in vivo and in vitro against the venom (2mg/kg) ...

Post-Junctional Alpha Adrenoceftors in the Anococcygeus Muscle and VAS Deferens: A Comparative Study in Normotensive and Spontaneously Hypertensive Rats

ABSTRACTThe characteristics of the post-junctional -aarenoceptors in the isolated anococcygeus muscle and vas deferens were compared in spontaneously hypertensive rats (SHR) and normotensive rats (NCR).Responses to CK —adrenoceptor agonists were obtained in the absence and presence of cocaine and of antagonists, Noradrenaline I (NA) and phenylephrine (PE) produced concentration related contrac— tions of the preparations which were antagonised by phentolamine5 prazosin and yohimbine...

EFFECT OF AN ETHANOLIC FRUIT EXTRACT OF XYLOPIA AETHIOPICA AND ITS MAJOR ALKALOID, XYLOPIC ACID, ON LEARNING AND MEMORY: A PRE-CLINICAL EVALUATION FROM A NEUROPHARMACOLOGICAL PERSPECTIVE

ABSTRACTBackground: Cognitive dysfunction, presenting as learning and memory impairment, is a common manifestation in many chronic diseases, including depression, epilepsy and Alzheimer’s disease. It could also be present without any known underlying medical condition. Till date, no drug has shown convincing efficacy in improving learning and memory deficits in these conditions although some medicinal plants are demonstrating promising effects. The aim of the study was to investigate the ef...

ANTIOXIDANT AND SELECTIVE CYTOTOXIC ACTIVITIES ON CANCER CELL LINES BY BIOACTIVATABLE COMPOUNDS IN EXTRACTS OF TERMITOMYCES SCHIMPERI (LYOPHYLLACEAE)

ABSTRACTBACKGROUND: Termitomyces schimperi (TS) is an edible mushroom that is known to possesscertain therapeutic properties. Anecdotal report from La Cote d’Ivoire suggests that themushroom is traditionally used in combination with kaolin, to manage a number of cancers.There is, however, a dearth of information on its antioxidant and anticancer properties with orwithout kaolin.AIMS: The aims of this study were to determine the antioxidant and cytotoxic potential ofaqueous and ethanolic ext...


1 - 15 Of 20 Results