ABSTRACT The aim of the present study was to investigate the physicochemical equivalence and compare the dissolution rate of thirteen brands of metronidazole tablets collected from retail pharmacies in Nigerian markets. This study sought to apply the BCS biowaiver requirements to assess the equivalence of commonly interchanged generic Metronidazole tablets with their innovator product in Nigeria. Solubility of active pharmaceutical ingredients (API) has always been a concern for formulators,...
INTRODUCTION In pharmaceutical sciences, microspheres have been extensively studied for use as drug delivery systems, where they have been shown to protect sensitive drugs from enzymatic degradation and allow controlled release, and tissue targeting of the formulated drug. Starch modification, can be used to tailor starch to specific applications. Pantoprazole, a proton pump inhibitor which suppresses the acid production by inhibiting the H+ K+ATPase. In this study, M. pruriens starch, a loc...
ABSTRACT Based on the ethnomedicinal use and belief that Stachytarpheta jamaicensis (SJ) can increase milk supply in lactating women, experimental studies were carried out to determine the effect of crude methanol extract (CME) and fractions of SJ leaves on serum PRL levels. The pharmacognostic standards, preliminary phytochemical analysis and acute toxicity study were also carried out. The fresh leaves were collected, cleaned, air-dried and pulverized. A photomicroscope was used in the quali...