ABSTRACT There is dearth of scientific information on the effects of Hybanthus enneaspermus (HE) and Parquetina nigrescens (PN) on female reproduction, pregnancy and its outcome. Yet, these two medicinal plants remain the first line of medicinal plants commonly used by Traditional Birth Attendants in care of women before, during and after pregnancy in South-west Nigeria. The effect of aqueous leaf extract of Hybanthus enneaspermus (HEaq) and Parquetina nigrescens (PNaq) on female reproductio...
ABSTRACT Extracts of Hibiscus sabdariffa (HS) are widely believed in folk medicine to be effective in the treatment of a variety of ailments. Aqueous extract of HS has been reported to decrease fluid and food consumption and weight gain in non-pregnant rats through mechanisms not yet fully understood. Thus when aqueous extract of HS is administered to pregnant and lactating animals, it may lead to decreased food consumption and consequently, malnutrition in these animals. Maternal malnutriti...
ABSTRACT Background: Thermal burns injuries are associated with changes in biochemical parameters which require specialized care. Burn shock is the first consequence of deep and extensive burns that constitutes the main cause of mortality if local and systemic treatments are not correct and timely. Changes in the biochemical parameters are attributed to the hypermetabolic state, arising mainly from increases in adrenaline release, hemolysis, sepsis, loss of fluid and electrolytes that requi...
ABSTRACT The toxicology of six suspected poisonous plants Leucaena leucocephala Benth, Tribulus terrestris Linn Eugenia uniflora Linn, Dichapetalum madagascasience Poir, Lantana camara Linn, and Solanum torvum Benth); were evaluated in Sprague Dawley rats weighing between 200-300 grams. Two of these plants, Lantana camara and ~. madagascasience were re-evaluated in West African dwarf goats. Spectrophotometric and titrimetric methods were also used to determine some inorganic and metallic cont...
ABSTRACT Background: Preeclampsia is a peculiar human pregnancy condition with heightened immune response, oxidative stress, hypoxia and reduced angiogenesis. These features of preeclampsia which are influenced by leptin which causes endothelial dysfunction; the main pathology of this condition. Hypertension, which is a diagnostic marker of preeclampsia, is also associated with increased leptin level. This implicates leptin in preeclampsia pathogenesis. Data from Caucasians and Asians show hi...
ABSTRACT Background: Pregnancies complicated by pre-eclampsia are associated with a high rate of maternal and fetal morbidity and mortality. The only effective treatment of pre-eclampsia is premature delivery of the baby and the placenta which can result in neonatal complications. Antiangiogenic and angiogenic factors have been implicated in the pathophysiology of preeclampsia resulting in of placental ischemia with subsequent maternal endothelial cell dysfunction and fetal complications. Gen...
ABSTRACT Background: The presence of metabolic syndrome (MetS) has been associated with an increased risk of stroke. The indicators of MetS that predispose individuals to stroke still persist after stroke. There is insufficient information on MetS in acute ischaemic and haemorrhagic stroke survivors at Korle-Bu Teaching Hospital. Aim: This study assessed metabolic syndrome in acute stroke survivors at Korle-Bu Teaching Hospital. Method: This was a cross-sectional study involving patients at t...
ABSTRACT Background: Cardiovascular complication accounts for greater number of deaths that occur in lupus patients who have chronic inflammation. However, arterial stiffness is used to predict diseases of the cardiovascular system, characterized by persistent inflammation which affects adipose tissues, dysregulation of adipokines and hyperinsulinemia, tend to quicken hardening of arteries in patients with systemic lupus erythematosus (SLE). Aim: This study investigated association existing b...
ABSTRACT It is over a century since the discovery of Sickle Cell Disease (SCD) and since then, a lot more is still being discovered about the pathophysiology of the disease. Notable amongst the various factors that affect the disease’s pathophysiology and management is red cell dehydration. Factors that affect cellular dehydration and serum osmolality in SCD patients are not very clearly understood. An objective method among of assessing SCD patient’s hydration status is by measuring the ...
Abstract Diabetes mellitus is associated with increased risk of cardiovascular diseases (CVDs) and mortality. Type 2 diabetes (T2DM) exerts it deleterious effects through the blood vessel which may lead to hypoperfusion and end organ damage. The ability to characterize the arterial system and derive related biomarkers that can predict the occurrence of CVDs and discriminate high risk subject for management would be of immense importance. Assessment of arterial stiffness and central hemodynami...
STRUCTURED ABSTRACT BACKGROUND: Although spinal Anaesthesia remains the anaesthetic technique of choice for many surgeries below the umbilicus, it may be associated with increased risk of cardiopulmonary complications such as hypotension, bradycardia and intraoperative cardiopulmonary arrest. Spinal Anaesthesia blocks autonomic, motor and sensory nerves which may affect pulmonary function. In the general population, reduction in the forced expiratory volume in one second (FEV1) is a robust pr...
ABSTRACT BACKGROUND Spastic Cerebral palsy accounts for 70-80% of all types of Cerebral palsy. Spasticity as a major feature limits and restricts patients’ ability to walk, stand, sit, or roll effectively due to excessive muscle contraction interfering with lengthening of the affected muscles. It poses a challenge even though there are well known interventions. Rehabilitation which includes physiotherapy is one of the widely accepted interventions. Physiotherapists in other countries and in...
ABSTRACT Background: Natural cocoa powder (NCP) has been recognized to possess significant amounts of procyanidin flavonoids, methylxanthines, catechin and epicatechin with healthful effects. Stimulus for this work was to validate claims that NCP was a healthful product best for the aged with cardiovascular health problems and also for daily consumption for all age groups as a preventive measure. Literature review does not show any work done in healthy adult Ghanaians involving the long term...