Research Papers/Topics in Biochemistry

EFFECT OF CELLGEVITY ON CATALASE ACTIVITY OF RAT MODEL OF PARKINSON DISEASE

Parkinson’s disease is a degenerative neurological disease, which is characterized by the preferential death of dopaminergic neurons in the Substantia Nigra. Current drug treatments are aimed primarily for the treatment of symptoms to improve the quality of life. Therefore, there is a need to find out new therapeutic strategies that not only provide relief but also halt or reverse the neuronal damage hampering PD progression, thus this research therefore aimed at investigating th...

Effect of Emilia Sonchifolia on Globulin and Bilirubin level of Winter rat

ABSTRACT The place of adequate nutrition in the live of the young especially in the recently weaned cannot be overemphasized. The abrupt change in diet, leading to possible immune system weakness and disease conditions, is a focal point in the care of the young. This project examined serum globulin and bilirubin levels in weanling rats whose feed was supplemented with Emilia sonchifolia leaf extract.Present investigation were carried out on the effect of ethanolic extract of Emilia Sonchifol...

FERTILITY ENHANCING POTENTIAL AND METABOLIC EFFECT OF ETHANOLIC ROOT EXTRACT OF SPHENOCENTRUM JOLLYANUM IN MALE WISTAR RATS

The overall objective of this study is to scientifically evaluate the claimed fertility enhancing potential and to assess the metabolic effect of the ethanolic extract of  Sphenocentrum jollyanum pierre (Menispermaceae) root using male wistar rats as model.The specific objectives include the following·         To determine the proximate and phytochemical composition of the ethanolic extract of Sphenocentrum jollyanum  (root) this will ...

EFFECT OF SWIMMING TRAINING ON COGNITIVE FUNCTION IN SCOPOLAMINE INDUCED DEMENTIA IN MICE.

ABSTRACTThe present study investigated the effects of a 2-week swimming exercise on scopolamine-induced dementia in a mice model. Thirty-two mice, were randomly divided into four groups (8 rats in each). Group A served as control without exercise and received saline only; Group B served as induced control and receive a single dose of scopolamine (1 mg/kg, i.p.) only on the last day; group C mice were subjected to short-term exercise (swimming) + single dose of scopolamine (1 mg/kg, i.p.) on t...

NUTRITIONAL AND ANTI-NUTRITIONAL CONTENTS OF INGREDIENTS USED IN PREPARING GRANULATED DUMPLING (DAMBU)

ABSTRACTNutritional and antinutritional content of ingredient used in preparing dambu were determined by proximate composition, vitamins, minerals and antinutritional contents analysis. Maize and Moringa flowers were used as the experimental samples and the work was conducted in triplicate which resulted in obtaining the experimental result in mean and standard deviation. Appreciable amount of nutritive composition were obtain in the used maize and Moringa samples. While the antinutritional c...

KIDNEY FUNCTION PARAMETERS F PLASMODIUM PASSAGED MICE TREATED WITH CRUDE METHANOLEXTRACT OF AZADIRACHTA INDICA (NEEM)

ABSTRACT Kidney function parameters were evaluated in plasmodium berghei infected mice treated with crude methanol extracts of Azadirachta indica leaves in this study. A total of  forty (40) male albino mice inoculated with quinine resistant strains of plasmodium berghei were randomized into nine (9) groups of (4) animals each while four additional mice serve as the uninfected control group. Group 1 was treated with tween 80, group 2 treated with 10mg/kg chloroquine while groups 3,4...

Consumption of green tea (Camellia sinensis)

ABSTRACT Consumption of green tea (Camellia sinensis) may provide protection against chronic diseases, including cancer. Green tea polyphenols are believed to be responsible for this cancer preventive effect, and the antioxidant activity of the green tea polyphenols has been implicated as a potential mechanism. This hypothesis has been difficult to study in vivo due to metabolism of these compounds and poor understanding of the redox environment in vivo. Green tea polyphenols can be...

Antioxidant Defense System in a Germinating P.Vulgaris

Phaseolus vulgaris, Common Bean is a herbaceous annual plant grown worldwide for its edible dry seed (known as just "beans") or unripe fruit (green beans) and a member of the legume family Fabaceae.  They are quite popular amongst the natives because of its high protein, minerals and vitamins content (Gentry et al., 1999).The use of a wide range of chemicals to destroy pests and weeds is an important aspect of agricultural practice in both developed and developing countries but there is a wi...

Antioxidant Property of Coconut (Cocos nucifera) Water

ABSTRACTCoconut water is a natural nutritious beverage that contains several biologically active compounds. This study was set up to evaluate the antioxidant potential of coconut water. Twenty five adult male albino rats, used in this work, were grouped into five (A, B, C, D and E), of five rats per group. Groups A, B, C and D were administered orally with 0.5, 1.0, 1.5 and 2.0mg/kg body weight respectively of the coconut water for seven consecutive days. Group E was the control. Giutathione ...

COMPARATIVE ANALYSIS OF HEAVY METALS IN BRASSICA OLERACEA FROM KENYATTA MARKET, NAIROBI AND KAGOCHI, KARATINA

ABSTRACTVegetables has been an integral part of day to day diet for so many people in Kenya. It is used in the form of raw fruits, dried, powdered or cooked vegetables. This is a research that addresses this way of living to act as a precaution towards making the food healthier. It is with a significant concentration in Kenyatta market than Kagochi while chromium’s level was higher in Kagochi compared to Kenyatta market.From the above figures of heavy metals, it was conc...

The potential protective effects of Diphenyl-diselenide (PhSe)2 on Mercuric chloride-Induced Nephrotoxicity in female wistar rats

ABSTRACT Evidences have implicated free radicals or reactive oxygen species in mercuric chloride-induced nephrotoxicity. Diphenyl diselenide (PhSe)2, a simple and stable organoselenium compound, has been proposed as a good candidate for pharmacological and therapeutic purposes. This particular study was designed to investigate the protective effect of (PhSe)2 against mercuric chloride-induced nephrotoxicity. In this study, 44 female Wistar rats with weights ranging from 125g and 180g were r...

ACTIVATION OF CASPASE ACTIVITY IN RAT LIVER CELLS BY METHANOL EXTRACT OF GLORIOSA SUPERBA

Activation of caspase 3&9 by methanol extract of Gloriosa superba ABSTRACTMitochondrion is the key regulator in cellular energy homeostasis and plays a central role in determining cell apoptotic process; it is therefore regarded as a vital target for cancer chemotherapy. Cancer is obviously one of the most common areas where demand for alternative treatment is overwhelming. Many investigations revealed that bioactive compounds in natural products can act on mitochondria to trigger the perme...

Caspase activation by methanol extract of Gloriosa superba on rat liver cells

Methanol extract of Gloriosa superba in this research was adopted due to the presence of photochemicals present in the plant. This photochemicals are known to act as antioxidants and anti tumor agent but it is not yet known if the activity of the plant is through the mitochondria mediated pathway, caspase activation and induction of apoptosis where up regulation is necessary 

ANTIBIOTIC SUSCEPTIBILITY OF Staphylococcus aureus IN CATTLE

ABSTRACT        This work was done to determine the antibiotic susceptibility of Staphylococcus aureus among cattle in Owerri, Imo State. A total of twenty four (24) samples were collected which were cultured on appropriate bacteriological media. The Staphylococcus aureus isolates were identified by standard biochemical tests. Antibiotic susceptibility profile of the isolates was performed according to Clinical and Laboratory Standard Institute (CLS...

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