Research Papers/Topics in Biochemistry

Toxicity Of Single And Quatenary Mixture Of Antibiotics To Natural Microbial Community.

ABSTRACTThe toxicities of single antibiotics: ciprofloxacin, azithromycin, sulfathiazole and amoxicillinand their quaternary mixtures in different ratios were examined on three organismsStaphylococcus aureus, Bacillus cereus and Micrococcus luteus all isolated from Nworie Riverfrom three different points including the point of effluent discharge of a hospital. Toxicity ofantibiotics and mixtures was assessed using inhibition of total dehydrogenase assay method.Result obtained from the study s...

Effects of Extracts of The Anti-Asthmatic Plant Thonninga Sanguinea on Anaphylaxis in The Guinea Pig

ABSTRACT Thonningia sanguinea is one of the herbal preparations vised prophylactieally against asthma at the Centre for Scientific Research into Plant Medicine. Preparations of this plant are used with Desmodium adseendens which has been shown to be anti-anaphylactic. The anaphylactic reaction is a basic underlying phenomenon in asthma. In this work, the effects of T. eanguinea preparations were evaluated on some aspects of the disease. The method adopted was experimental anaphylaxis in...

Antidiabetic Properties of Total Phenol Content of Zanthoxylum zanthoxyloides Leaves on Albino Rats

ABSTRACT    In this study, we evaluated the effect of the total phenol extract of Zanthoxylum zanthoxyloides leaves on oral glucose tolerance, lipid profile, liver function, oxidative stress parameters, and pancreas histopathology in diabetic rats. Diabetes was induced in rats by administration of alloxan monohydrate in a dose of 130 mg/kg b/w. Total phenol content of Z. zanthoxyloides leaves was administered to rats at 100, 200 and 400 mg/kg b/w daily for 15 days. Blood gluco...

THE EFFECT OF TEMPERATURE ON GLUTATHIONE PEROXIDASE FROM FISH

Glutathione Peroxidase (GPx) family of enzymes plays important roles in the protection of organisms from oxidative damage. GPx converts reduced glutathione (GSH) to oxidized glutathione (GSSG) while reducing lipid hydroperoxides to their corresponding alcohols or free hydrogen peroxide to water. This study was conducted to investigate the possible effects of temperature in vivo on Glutathione peroxidase (GPX) oxidative activity in fish tissues.An adult fully grown cat fish, (the African flath...

ANTI-TRYPANOSOMAL ACTIVITY OF N-HEXANE AND DICHLOROMETHANE EXTRACTS OF VITELLARIA PARADOXA LEAVES ON TRYPANOSOMA BRUCEI BRUCEI INFECTED MICE

African trypanosomosis is a vector-borne disease that is caused by a flagellated protozoon of the genus Trypanosoma. Large populations of human and domestic animals are at risk of infections with trypanosomes in vast areas of sub-Saharan Africa where the disease is endemic. Human infections with trypanosomes are referred to as Human African Trypanosomosis (HAT) while animal infections are known as African Animal Trypanosomosis (AAT). These infections are more prevalent in the rural areas (Ato...

Investigation of the Pancreatic Effect of Buccholzia Coricacea Formulated Diet in Sucrose Fed Pregnant Rats and their Offspring

ABSTRACTSeveral plants have been used in the treatment of various disorders without scientific basis. The present study examine the pancreatic effect of Buchholzia coriacea formulated diet in sucrose-fed pregnant rats and their offspring. Buchholzia coriacea seeds were obtained from Ogbete main market, Enugu state, identified, dried and grounded using a miller machine. 10% of the seed powder was used to formulate their diet. Thirty (240) adult female and six (6) adult male albino rats (180-25...

Hypolipidemic and Antioxidant Capacity of Methanol Leaf Extract of Kigelia Africana in Alloxan Induced Diabetic Albino Rats

ABSTRACTDiabetic mellitus is a metabolic disorder resulting from a defect in insulin secretion , insulin action or both . The deficiency of insulin leads to chronic hyperglycemia with disturbances of carbohydrate , fats  and protein metabolism. Kigelia Africana is a sausage tree known to have medicinal values. The aim of this work is to evaluate the hypolipidemic and antioxidant capacity of the plant , methanol leaf extract of kigelia Africana which was used for the study. The leaves wer...

Determination of Heavy Metals and Proximate Analysis in Some Selected Cereals

ABSTRACTThis research was conducted to determine the concentrations of heavy metals and proximate composition of different cereals (maize, millet and rice). Two different samples each sold in two different markets (Ogbete and Gariki) in Enugu, were used for this work, using atomic, absorption spectrophotometer. The heavy metal screening of the cereal samples showed the presence of arsenic in the range of 0.456ppm-0.955ppm but was not detected in sample E and f which are the two different rice...

Relationship Between Anaemia, Glucose-6-Phosphate Dehydrogenase Deficiency and Oxidative Stress Among Malaria Patients Visiting ESUT Teaching Hospital, Enugu Nigeria

ABSTRACTMalaria is a significant public health problem in the world especially in in sub-Saharan Africa. One of the key contributory factors to the development and progression of malaria and its complications is oxidative stress, a condition characterized by increased production of free radicals or impaired antioxidant defence system. Glucose-6-phosphate dehydrogenase (G-6-PD) produces NADPH which intends regenerate reduced glutathione (GSH), an antioxidant which helps in the removal of free ...

Evaluation of Oxytocic Potential of Methanol Extracted sida acuta on Female Albino Rats

ABSTRACTPlants have long been a source of nutrition and therapy to man. The medicinal value of these plants lies in some chemical substances that produce a definite physiological action in the human body. This study evaluated the oxytocic potential of methanol extract of Sida acuta on female albino rats in vitro. Oxytocin was used as a standard drug though it is a biochemically synthesized hormone that act on distant hormone receptor to induce contractions. The methanol extract was prepared u...

Phytochemical and heavy metals levels of selected vegetables (Carrot, Lettuce, and Tomato) grown at Kalambaina area Sokoto

The presence study aimed to investigate the phytochemical and heavy metals level in selected vegetables grown in Kalambaina area ,the phytochemical were determined using analytical methods and the heavy metals (Cd, Pb, Zn, Ni, Cr and Cu) concentration in vegetables and water were determined using atomic absorption spectroscopy (AAS). The study indicate the presence of flavanoid, alkaloids, steroids, volatile oil, saponin glycosides in all the vegetables. The concentration of copper was found ...

EFFECT OF CELLGEVITY ON CATALASE ACTIVITY OF RAT MODEL OF PARKINSON DISEASE

Parkinson’s disease is a degenerative neurological disease, which is characterized by the preferential death of dopaminergic neurons in the Substantia Nigra. Current drug treatments are aimed primarily for the treatment of symptoms to improve the quality of life. Therefore, there is a need to find out new therapeutic strategies that not only provide relief but also halt or reverse the neuronal damage hampering PD progression, thus this research therefore aimed at investigating th...

Effect of Emilia Sonchifolia on Globulin and Bilirubin level of Winter rat

ABSTRACT The place of adequate nutrition in the live of the young especially in the recently weaned cannot be overemphasized. The abrupt change in diet, leading to possible immune system weakness and disease conditions, is a focal point in the care of the young. This project examined serum globulin and bilirubin levels in weanling rats whose feed was supplemented with Emilia sonchifolia leaf extract.Present investigation were carried out on the effect of ethanolic extract of Emilia Sonchifol...

FERTILITY ENHANCING POTENTIAL AND METABOLIC EFFECT OF ETHANOLIC ROOT EXTRACT OF SPHENOCENTRUM JOLLYANUM IN MALE WISTAR RATS

The overall objective of this study is to scientifically evaluate the claimed fertility enhancing potential and to assess the metabolic effect of the ethanolic extract of  Sphenocentrum jollyanum pierre (Menispermaceae) root using male wistar rats as model.The specific objectives include the following·         To determine the proximate and phytochemical composition of the ethanolic extract of Sphenocentrum jollyanum  (root) this will ...

EFFECT OF SWIMMING TRAINING ON COGNITIVE FUNCTION IN SCOPOLAMINE INDUCED DEMENTIA IN MICE.

ABSTRACTThe present study investigated the effects of a 2-week swimming exercise on scopolamine-induced dementia in a mice model. Thirty-two mice, were randomly divided into four groups (8 rats in each). Group A served as control without exercise and received saline only; Group B served as induced control and receive a single dose of scopolamine (1 mg/kg, i.p.) only on the last day; group C mice were subjected to short-term exercise (swimming) + single dose of scopolamine (1 mg/kg, i.p.) on t...


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