Research Papers/Topics in Biochemistry

The potential protective effects of Diphenyl-diselenide (PhSe)2 on Mercuric chloride-Induced Nephrotoxicity in female wistar rats

ABSTRACT Evidences have implicated free radicals or reactive oxygen species in mercuric chloride-induced nephrotoxicity. Diphenyl diselenide (PhSe)2, a simple and stable organoselenium compound, has been proposed as a good candidate for pharmacological and therapeutic purposes. This particular study was designed to investigate the protective effect of (PhSe)2 against mercuric chloride-induced nephrotoxicity. In this study, 44 female Wistar rats with weights ranging from 125g and 180g were r...

ACTIVATION OF CASPASE ACTIVITY IN RAT LIVER CELLS BY METHANOL EXTRACT OF GLORIOSA SUPERBA

Activation of caspase 3&9 by methanol extract of Gloriosa superba ABSTRACTMitochondrion is the key regulator in cellular energy homeostasis and plays a central role in determining cell apoptotic process; it is therefore regarded as a vital target for cancer chemotherapy. Cancer is obviously one of the most common areas where demand for alternative treatment is overwhelming. Many investigations revealed that bioactive compounds in natural products can act on mitochondria to trigger the perme...

Caspase activation by methanol extract of Gloriosa superba on rat liver cells

Methanol extract of Gloriosa superba in this research was adopted due to the presence of photochemicals present in the plant. This photochemicals are known to act as antioxidants and anti tumor agent but it is not yet known if the activity of the plant is through the mitochondria mediated pathway, caspase activation and induction of apoptosis where up regulation is necessary 

ANTIBIOTIC SUSCEPTIBILITY OF Staphylococcus aureus IN CATTLE

ABSTRACT        This work was done to determine the antibiotic susceptibility of Staphylococcus aureus among cattle in Owerri, Imo State. A total of twenty four (24) samples were collected which were cultured on appropriate bacteriological media. The Staphylococcus aureus isolates were identified by standard biochemical tests. Antibiotic susceptibility profile of the isolates was performed according to Clinical and Laboratory Standard Institute (CLS...

Assessment of some micronutrient in sesamum indicum

ABSTRACTSesamun indicum is used for both domestic and commercial purpose in Northern Nigeria, this research is aimed at assessing some micronutrients in sesamum indicum seed in Nguru town, using atomic absorption spectroscopy, spectrophotometric and flame photometric techniques in order to determine the elemental concentrations of  some elements in sesame seeds collected from Nguru town, Nguru local government of Yobe state, Nigeria. The results showed the presence of sodium (Na), potassium ...

Student industrial work experience report at Nigerian Bottling Company, Asejire

 ABSTRACTThe students industrial work experience scheme (SIWES) is a skill impacting program designed to expose and prepare students of universities and other tertiary institutions for the industrial work situation that may be encountered after school. My SIWES program was undertaken at Nigeria Bottling Company limited, Asejire plant, Ibadan; a company that deals with the manufacturing of non-alcoholic beverage products such as Coca-Cola, limca, Fanta orange etc. The company has vario...

Comparative biochemical effect ofoleanolic acid and rutin on acute kidney injury in wistar rats

ABSTRACTThe inability of an organism to efficiently remove excess waste from the body have been a major issues attached to acute kidney injury (AKI) which is the most common cause of organ dysfunction. Oleanolic acid and rutin which are from the families of saponin and flavonoid respectively have been discovered to possess certain biological activities such as anti-oxidant, anti-inflammation, anti-viral and nephroprotective activities that can help in therapeutic management of acute k...

COMPARATIVE STUDY ON THE PHYTOCHEMICAL ANALYSES, ANTIOXIDANT ACTIVITIES AND PROXIMATE ANALYSES OF NESCAFE CAFFEINATED, DECAFFEINATED AND LIVEN ALKALINE COFFEE

ABSTRACTThe consumption of the popular beverage coffee, increases day by day. However, upcoming brands of coffee with health benefits made by claims of the product ignites curiosity in the components of the coffee. The current study deals with the phytochemical analysis, antioxidant capacity and proximate analysis of Liven Alkaline Coffee, Nescafe Caffeinated and Nescafe Decaffeinated coffee performed using standard procedures. The phytochemical analysis revealed higher contents of carbohydra...

The Toxicological Effects of Cypermethrin Administration on the Liver, Kidney, Brain and Bone Marrow of Female Rats and the Possible Ameliorative Effects of the Methalonic Leaf Extract of Jat

TABLE OF CONTENTSContents pagesCover page iDeclaration iiCertification iiiDedication ivAcknowledgement vAbstract viTable of content List of FiguresList of PlatesList of TablesCHAPTER ONEItroduction 11.1 Justification 31.2 Objectives 41.3 AimCHAPTER TWOLiterature Review2.1 Pesticide2.1.1 Uses of pesticides2.1.2 Types of Pesticides2.1.3 Cypermethrin2.1.3.1 Mechanism of Action of Cypermet...

Serum Liver Enzymes Profile and Antioxidant Status of Male Wistar Rats Following Feeding with Cocos Nucifera

The work was aimed at investigating the effect of Cocus nucifera on male albino rats. A number of rats were placed in groups and all groups were fed Cocus nucifera except one group, the control group. Analysis of results was done with ANOVA.

EFFECT OF SHEA BUTTER (Vitellaria paradoxa) RICHDIET ON GENTAMICIN INDUCED NEPHROTOXICITY IN RATS

Abstract The effect of Shea butter rich diet on gentamicin induced nephrotoxicity in rats was determined. Thirty (30) male and female albino rats grouped into 6 (normal, negative, positive, 10%, 20% and 30% Shea butter rich diet groups respectively) of 5 rats each were used for the study. Phytochemical analysis was carried out on the Shea butter used for this study which revealed the presence of saponin, tannin, alkaloid, terpenoid, flavonoid, and reducing sugar, while coumarin was absent. N...

COMPARATIVE ASSESSMENT OF PHYTOCHEMICAL CONTENT AND ANTIOXIDANT POTENTIAL OF Azadirachta indica AND Parquetina nigrescens LEAVES

ABSTRACTComparative assessment of the phytochemical content and antioxidant potential of Azadirachta indica (neem) and Parquetina nigrescens (bullock) is the aim of this study. In order to achieve this, both plants were harvested from the botanical garden, University of Ibadan. The leaves were removed from the stem, washed with running water to remove contaminants, oven dried at 37˚C and milled into powder.The qualitative analyses of both plants were investigated after which six selected phy...

EFFECTOF METHANOL EXTRACT OF cirtullus lanatus SEEDSON HEMATOLOGICAL PARAMETERS IN MODULATION OF DIHYDROTESTOSTERONE ESTRADIOL VELERATE INDUCED BENIGN PROSTATIC HYPERPLASIA IN MALE WISTAR RA

Citrullus lanatus is medicinal plants believed to have many agents acting in different ways for the health benefits of human. This study investigated the acute phytochemical contents and effect of the methanol extract on weight changes, relative organ weight, hematological parameters and biomarkers of prostate dysfunction. The result indicated the presence of alkaloids, terpenes, flavonoids, Reducing sugar, tannins and phenols. Acute toxicity studies showed that the extract was safe at 5000mg...

Electrolyte Content of Some Soft Drinks

AbstractSoft drinks are consumed daily in Nigeria due to their characteristic taste, palatability, affordability and thirst quenching potential. This study quantifies the amount of electrolytes of Biochemical significance in selected soft drinks sold in Port Harcourt and their pH values. The samples included six frequently consumed soft drinks; (Coke, Sprite, Fayrouz, Mountain-Dew, Fanta and Pepsi). The results showed that the samples contain relatively high amount of Sodium(Na+) ranging from...


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