Research Papers/Topics in Biostatistics

Molecular Characterisation Of Gp41 And Gp120 V3 Loop In Hiv-1c Infected Patients Failing Salvage Therapy In Botswana

ABSTRACT Multi-drug resistant (MDR) HIV-1 infection remains a challenge in individuals with extensive antiretroviral treatment (ART) experience, in terms of high mortality and probability of onward transmission. New therapeutic options within old drug and new drug classes are therefore essential. This study sought to determine coreceptor usage and T20 resistance associated mutations in patients failing salvage therapy from clinics around Botswana, through characterizing gp120 V3 loo...

Effect Of Processing On Crude Fat And Beta-Carotene Content In Three Sweet Potato Varieties

ABSTRACT Sweet potato (Ipomoea batatas) is one of the crops being considered for the diversification of the staple diet to enhance food security in Zimbabwe in the face of climate change and economic challenges. One of the hurdles preventing adoption of sweet potato as a staple food is its short shelf-life. There has been a call to explore means of preserving sweet potato hence increasing its shelf-life and one method of preservation is processing sweet potato into flour. However, this ...

Modelling Progression Of HIV/AIDS Disease Using Homogenous Semimarkov Processes: Cohort Study, Namibia

Abstract The progression of HIV infection to AIDS and then to death can be considered as a Markovan stochastic process. Disease progression can be broken down into a finite number of intermediate states, based on CD4 counts. The four states of the Markov process of HIV/AIDS progression are commonly defined as: S1: CD4 count > 500 cells/microlitre of blood; S2: 350 < CD4 count ≤ 500 cells/microlitre of blood; S3: 200 < CD4 count ≤ 350 cells/microlitre of blood; S4: CD4 count ≤ 200 ...

Determinants Of All-Cause Maternal Mortality In Ghana: A Multivariate Decomposition Analysis Of 2007 And 2017 Ghana Maternal Health Surveys

ABSTRACT Background Maternal mortality has seen a significant decline in Ghana over last decade. Stakeholders and government continue to invest in strategic policies aimed to further decrease the ratio of maternal mortality. To achieve the desired results, interventions must be tailored toward specific factors in order to further strengthen the remedy to this health menace. Even though, there has been a decline over the years, international target and standards yet to be achieved. Meth...

A Spatial Temporal Analysis Of Survival Among Tb And Hiv Co–Infected Patients In Erongo Region, Namibi

Abstract Namibia is among the Sub-Sahara African countries with a high burden of TB and HIV coinfection in the world. The interaction between TB and HIV/AIDS makes the diagnosis and management of the co-infection difficult. The purpose of this study is to identify risk factors, assess spatial and space-time clusters mortality among TB and HIV in Erongo Region. A retrospective cohort study from 2003 to 2017 was carried out using data consisting of 3145 subjects from all the 16 health fac...

A Copula Approach To Sample Selection Modeling Of Treatment Adherence And Viral Suppression Among HIV Patients On Antiretroviral Therapy (ART) In Namibia

ABSTRACT Namibia has a generalized human immunodeficiency virus (HIV) epidemic, with HIV mainly transmitted through heterosexual transmission. Although the number of people receiving ART has increased, the achievement of the 90-90-90 strategy on testing, treatment and suppression has not been evaluated. Moreover, examining factors associated with treatment adherence and viral suppression will assist in designing appropriate accelerated interventions. However, modelling treatment adheren...

An Application Of Survival Analysis On The Prevalence And Risk Factors Of Breast Cancer In Namibia

ABSTRACT Cancer is a universal disease that affects people regardless of race, sex, socio-economic status and culture. With just an approximated population size of 2.3 million people NSA (2011), Namibia is not excluded from this. If not detected on time and treated on time, cancer can make treatment less likely to succeed and reduce the chances of survival. The study was aimed at examining the prevalence and trends for breast cancer patients, regardless of patients’ sex, as well as es...

Body Wasting Among Tuberculosis Patients In Urban Uganda

Background Although body wasting is a cardinal feature of tuberculosis, its etiology and management is poorly understood; and its assessment is overlooked in research and in clinical practice. Objective We established whether body wasting modifies survival and body composition changes during and after tuberculosis treatment; whether HIV modifies dietary intake among tuberculosis patients; whether dietary intake differs by wasting and severity of disease status; and whether dietary intak...

Performance Comparison Of Data Mining Techniques For Predicting Hiv Status Among Female Sex Workers In Ghana

ABSTRACT Introduction: The Human Immunodeficiency Virus (HIV) and the Acquired Immunodeficiency Syndrome (AIDS) disease still remains a global public health issue. An intriguing observation is the increasing rate of the infection among Female Sex Workers (FSW). HIV Testing Services (HTS) is an essential entry point for any HIV intervention service for FSW and studies like the Integrated Bio-Behavioral Surveillance Surveys (IBBSS) anonymously link the HIV test results of FSW with their r...

TRENDS AND DETERMINANTS OF COMPREHENSIVE KNOWLEDGE OF HIV/AIDS AMONG GHANAIANS BASED ON GHANA DEMOGRAPHIC HEALTH SURVEYS, 1998-2014.

ABSTRACTSince the first few cases were reported in 1981, HIV/AIDS and its related illnesses have beenone of the prominent causes of death globally. The disease has been estimated to reduceeconomic growth rates by 2-4% a year across Africa. This study examines the trends anddeterminants of comprehensive knowledge (CK) of HIV/AIDS among Ghanaians.The data used for this study were drawn from Ghana Demographic Health Surveys, 1998-2014. A separate analysis was performed on each survey-year data a...

COMPARATIVE ANALYSIS OF HIGHER-RISK SEXUAL BEHAVIOR IN TEN SUB-SAHARAN AFRICA COUNTRIES BASED ON THEIR THREE MOST CURRENT DEMOGRAPHIC AND HEALTH SURVEYS

ABSTRACTBackgroundHigher-Risk Sexual Behavior (H-RSB) is an act whereby people engage in sexual activities with multiple partners and do not consistently use condom. This practice is very common in sub-Saharan Africa (SSA). Though the prevalence of HIV is decreasing in sub-Saharan Africa H-RSB keep increasing in the region.ObjectiveThis study investigated and compared the trends and determinants of Higher-Risk Sexual Behavior among ten countries in SSA.MethodData for this study was obtained f...

QUANTITATIVE METHOD FOR FINDING SKIN DISEASE PREDICTION USING ORDINARY DIFFERENTIAL EQUATION

Overview1.1 Human skin and Its Functions1.2 Papulo-squamous and Erythemato-squamous skin diseases1.3 Statement of the Problem1.4 Study Aim and Objectives1.5 Significance of the Study1.6 Scope and Limitations&nbsp;2.1 Machine Learning&nbsp;2.2 Data Mining&nbsp;2.3 Mathematical Modeling......&nbsp;

A TIME SERIES MODEL OF HUMAN IMMUNODEFICIENCY VIRUS(HIV) AND TUBERCULOSIS (TB) COINFECTIONS AMONG FARMERS IN BENUE STATE

ABSTRACTThis dissertation applied time series model to study the impact of HIV and Tuberculosis with implications on  productivity of Benue state farmers using cointegrated autoregressive model and granger causality test. The study utilize monthly time series data on the serologically confirmed and reported cases of HIV/AIDS and tuberculosis (TB) in Benue state of Nigeria covering the fiscal year from January, 2007 to Decembers, 2016 and employed dickey-fuller Generalized least square...