Abstract: Plants possess a wide variety of secondary metabolites which have been found to exhibit antimicrobial, antioxidant and anti tumor activities. In Ethiopia, a number of plant species are traditionally used for the treatment of many diseases. Among these, Phytolacca dodecandra and Schinus molle which are abundantly available in many areas of the Country and they are widely known for their traditional medicinal values. This study was conducted with the objective of evaluating crude ext...
Abstract: Ethnobotanical studies are useful in documenting, analyzing and communicating knowledge and interaction between biodiversity and human society. The objective of this study was to conduct ethnobotanical study and document medicinal plants and indigenous knowledge in Tulo district. Ethnobotanical data was collected from December 2019 to January 2020 using semi-structured interview, focus group discussion and direct field observation with 80 randomly selected non traditional healers a...
ABSTRACT The aims of this research work were to formulate artemether-loaded self emulsifying drug delivery system (SEDDS), evaluate some of its in vitro and in vivo properties, and prevent drug precipitation through supersaturation approach. The solubility of artemether (ARM) in various oils, surfactants and cosurfactants was determined using the equilibrium solubility method. Vehicles such as Triacetin®, Labrasol® and Transcutol P® were selected as components of the formulation due to the...
ABSTRACT Antibiotics have remained the mainstay of drug therapy of infectious diseases worldwide. Their use is, however, limited by their numerous adverse effects and rapid development of microbial resistance. Identification of natural products from plants that may serve as valuable sources of antimicrobial agents for medicinal or agricultural uses seems to be a viable alternative to the conventional antibiotics. To achieve this goal, biological assays should be carried out in order to identi...
ABSTRACT The immunomodulatory properties of methanol extract and fractions of Hoslundia opposita leaf on Delayed-Type Hypersensitivity (DTH), primary and secondary humoral response and in vivo leucocyte mobilization were evaluated. Acute toxicity test of crude extract and phytochemistry study was carried out. The methanol extract (ME) at 200, 400 and 800 mg/kg body weight produced significant (P
ABSTRACT Effects of heavy metals on the Air Pollution Tolerance Indices (APTI) of five medicinal plants growing within quarry site in Ishi-Agu, Ebonyi State, Nigeria were studied. Following laboratory analysis of the leaves of the plants for metal load and four biochemical parameters of APTI computation. The metal load was determined by the Atomic Absorption spectrophotometric method, while the ascorbic acid was determined by the titremetric method, leaf extract pH by the electro-chemical te...
ABSTRACT The processing technique for production of alpha and microcystalline cellulose using Sorghum bicolor and Andropogon gayanus as starting materials was established. The effect of reagent type and concentration, pH, temperature, digestion and bleaching time on the quality and yield of the powdered cellulose grades &as studied. Acute toxicity test on the derived polymers was investigated using albino mice. The physicotechnical properties of the new polymeric materials were studied. A Car...
ABSTRACT: Tuberculosis is a global burden with one –third of the world’s population infected with the pathogen Mycobacterium tuberculosis and an annual 2 million deaths from the disease. This high incidence of infection and the increased rate of resistant strains of the organism (MDR- and XDR- TB) have called for an urgent need to develop new anti-tuberculosis drugs from plants. The crude extract of Uvaria afzelli Scott Elliot (Annonaceae) root bark, and leaves and root bark of Tetracera ...
ABSTRACT There has been an increase in the occurrence of antibiotic resistance among Salmonella enterica, one of the commonest causative agents of Salmonella infections. Fluoroquinolones and third generation cephalosporins are usually the drugs of choice in the management of Salmonella infections. Previous reports have indicated common occurrence of multi-drug resistance (MDR) including resistance to β-lactams and fluoroquinolones among clinical Gram-negative organisms. However, there is pa...