Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolavir

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Abstract
 Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury.  This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury. KV was administered at a dose of 100 or 200 mg/kg to male Wistar rats 1 h before a 30 min BCCAO/4 h reperfusion (I/R). This was followed by neurobehavioral assessment
and biochemical evaluations of cation levels, oxidative acetylcholinesterase (AChE) activity in the brain of animals. KV significantly restored altered cortical and striatal Ca2+, Na+, K+ and Mg2+ levels, ameliorated redox imbalance, lactic acidosis and modified AChE activity caused by I/R injury. The favourable neurobehavioural effects of KV correlated with biochemical outcomes. The pharmacological potential
of KV in the treatment and management of ischemic stroke and allied pathological conditions via multiple targets (neurotransmitter metabolism, bioenergetic failure and ionic homeostasis) is highlighted by the study.

TABLE OF CONTENT

1. ABSTRACT

2. INTRODUCTION

3. MATERIALS AND METHODS

4. RESULTS

5. DISCUSSION

6. CONCLUSION

7. ETHICAL APPROVAL

8. DISCLOSURE STATEMENT

9. REFERENCES

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APA

Boyede, O (2019). Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolavir. Afribary.com: Retrieved March 07, 2021, from https://afribary.com/works/improvement-of-2-vessel-occlusion-cerebral-ischaemia-reperfusion-induced-corticostriatal-electrolyte-and-redox-imbalance-lactic-acidosis-and-modified-acetylcholinesterase-activity-by-kolaviro

MLA 8th

Olowookere, Boyede. "Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolavir" Afribary.com. Afribary.com, 27 Jun. 2019, https://afribary.com/works/improvement-of-2-vessel-occlusion-cerebral-ischaemia-reperfusion-induced-corticostriatal-electrolyte-and-redox-imbalance-lactic-acidosis-and-modified-acetylcholinesterase-activity-by-kolaviro . Accessed 07 Mar. 2021.

MLA7

Olowookere, Boyede. "Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolavir". Afribary.com, Afribary.com, 27 Jun. 2019. Web. 07 Mar. 2021. < https://afribary.com/works/improvement-of-2-vessel-occlusion-cerebral-ischaemia-reperfusion-induced-corticostriatal-electrolyte-and-redox-imbalance-lactic-acidosis-and-modified-acetylcholinesterase-activity-by-kolaviro >.

Chicago

Olowookere, Boyede. "Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolavir" Afribary.com (2019). Accessed March 07, 2021. https://afribary.com/works/improvement-of-2-vessel-occlusion-cerebral-ischaemia-reperfusion-induced-corticostriatal-electrolyte-and-redox-imbalance-lactic-acidosis-and-modified-acetylcholinesterase-activity-by-kolaviro