ABSTRACT
Generation of reactive oxygen species beyond the antioxidant capacity of biological system has been reported to give rise to oxidative stress which through a series of events deregulates cellular functions, leading to oxidative damage and various pathological conditions. This study examined the effect of chloramphenicol and amoxicillin on liver microsomal enzymes Ca2+ - ATPase and Glucose-6-Phosphatase (G-6-P) and lipid peroxidation in rats. Male Wistar strain rats weighing 120 – 195 g were divided into four groups. Group one, the control group, received physiological saline, group two received Amoxicillin at 10.71 mg/kg, group three received Chloramphenicol at 28.57 mg/kg, while group four was administered combination of chloramphenicol and amoxicillin. Drugs were administered for ten days and the animals sacrificed on the eleventh day. Detection of oxidation in liver microsomal fraction was carried out by assessment of lipid peroxidation and conjugated diene. Ca2+-ATPase and G-6-P activities and total protein content were also measured. Data were analysed by ANOVA and Student’s T-Test. Significant (p
A, A & O, I (2021). Influence of Chloramphenicol and Amoxicillin on Rat Liver Microsomal Enzymes and Lipid Peroxidation. Afribary. Retrieved from https://afribary.com/works/influence-of-chloramphenicol-and-amoxicillin-on-rat-liver-microsomal-enzymes-and-lipid-peroxidation
A, Adesanoye and Ifezue O "Influence of Chloramphenicol and Amoxicillin on Rat Liver Microsomal Enzymes and Lipid Peroxidation" Afribary. Afribary, 24 Mar. 2021, https://afribary.com/works/influence-of-chloramphenicol-and-amoxicillin-on-rat-liver-microsomal-enzymes-and-lipid-peroxidation. Accessed 21 Nov. 2024.
A, Adesanoye, Ifezue O . "Influence of Chloramphenicol and Amoxicillin on Rat Liver Microsomal Enzymes and Lipid Peroxidation". Afribary, Afribary, 24 Mar. 2021. Web. 21 Nov. 2024. < https://afribary.com/works/influence-of-chloramphenicol-and-amoxicillin-on-rat-liver-microsomal-enzymes-and-lipid-peroxidation >.
A, Adesanoye and O, Ifezue . "Influence of Chloramphenicol and Amoxicillin on Rat Liver Microsomal Enzymes and Lipid Peroxidation" Afribary (2021). Accessed November 21, 2024. https://afribary.com/works/influence-of-chloramphenicol-and-amoxicillin-on-rat-liver-microsomal-enzymes-and-lipid-peroxidation