Neurodegeneration is defined as the progressive loss of structure or function of neurons in the body. Different forms of neurodegenerative disease include Parkinson disease, Alzheimer disease, multiple sclerosis, Huntington’s disease, and they are caused by different mechanism such as inflammation, mitochondria dysfunction, excitotoxicity etc. Insulin sensitizers have been discovered by researchers in managing Neurodegeneration and the main one used are the thiazolidinedione. Due to the activation of Peroxisome proliferator- activated gamma by the old thiazolidinedione, more researches were carried out to discover insulin sensitizers that bypass the PPAR-gamma and that leads to the development of MSDC-1060- A drug that bypass the PPAR-gamma and inhibit the mitochondria pyruvate carrier. The Mitochondria pyruvate carrier is a transport protein responsible for the movement of pyruvate from the cytosol into the mitochondria matrix. MSDC-1060 makes the mitochondria to use other substrates to balance its metabolism and hence attenuate neurodegeneration using autophagy augmentation, inflammation reduction and excitotoxicity reduction.
TABLE OF CONTENT
TABLE OF CONTENT v
LIST OF FIGURES vii
1.1 INTRODUCTION 1
2.1 NEURODEGENERATION 3
2.1.1 NEURODEGENERATIVE DISEASES AND TYPES 3
188.8.131.52 ALZHEIMER DISEASE 4
184.108.40.206 HUNTINGTON’S DISEASE 7
220.127.116.11 PARKINSON DISEASE 9
2.2 MITOCHONDRIA PYRUVATE CARRIER 12
2.3 THIAZOLIDINEDIONES (TZDs) AND NEURODEGENERATION 14
2.3.1 OLD GENERATION VERSUS NEW GENERATION TZDs 15
3.1 MECHANISMS OF ATTENUATING NEURODEGENERATION BY
3.1.1 AUTOPHAGY AUGMENTATION 19
3.1.2 INFLAMMATION REDUCTION 21
3.1.3 EXCITOTOXICITY REDUCTION 23
3.2 FUTURE PERCEPTIVE AND CLINICAL IMPLICATION OF MSDC-1060 25
4.0 CONCLUSION 28
Samuel, O (2019). Inhibition of mitochondria pyruvate carrier- an approach to attenuating neurodegeneration. Afribary.com: Retrieved March 04, 2021, from https://afribary.com/works/mitochondria-pyruvate-carrier-inhibition-an-atenuation-to-neurodegeneration
Ogunsola, Samuel. "Inhibition of mitochondria pyruvate carrier- an approach to attenuating neurodegeneration" Afribary.com. Afribary.com, 01 Feb. 2019, https://afribary.com/works/mitochondria-pyruvate-carrier-inhibition-an-atenuation-to-neurodegeneration . Accessed 04 Mar. 2021.
Ogunsola, Samuel. "Inhibition of mitochondria pyruvate carrier- an approach to attenuating neurodegeneration". Afribary.com, Afribary.com, 01 Feb. 2019. Web. 04 Mar. 2021. < https://afribary.com/works/mitochondria-pyruvate-carrier-inhibition-an-atenuation-to-neurodegeneration >.
Ogunsola, Samuel. "Inhibition of mitochondria pyruvate carrier- an approach to attenuating neurodegeneration" Afribary.com (2019). Accessed March 04, 2021. https://afribary.com/works/mitochondria-pyruvate-carrier-inhibition-an-atenuation-to-neurodegeneration