ABSTRACT
Neurodegeneration is defined as the progressive loss of structure or function of neurons in the body. Different forms of neurodegenerative disease include Parkinson disease, Alzheimer disease, multiple sclerosis, Huntington’s disease, and they are caused by different mechanism such as inflammation, mitochondria dysfunction, excitotoxicity etc. Insulin sensitizers have been discovered by researchers in managing Neurodegeneration and the main one used are the thiazolidinedione. Due to the activation of Peroxisome proliferator- activated gamma by the old thiazolidinedione, more researches were carried out to discover insulin sensitizers that bypass the PPAR-gamma and that leads to the development of MSDC-1060- A drug that bypass the PPAR-gamma and inhibit the mitochondria pyruvate carrier. The Mitochondria pyruvate carrier is a transport protein responsible for the movement of pyruvate from the cytosol into the mitochondria matrix. MSDC-1060 makes the mitochondria to use other substrates to balance its metabolism and hence attenuate neurodegeneration using autophagy augmentation, inflammation reduction and excitotoxicity reduction.
TABLE OF CONTENT
TITLE PAGES
TITLE i
CERTIFICATION ii
DEDICATION iii
ACKNOWLEDGEMENT iv
TABLE OF CONTENT v
LIST OF FIGURES vii
ABSTRACT viii
CHAPTER ONE
1.1 INTRODUCTION 1
CHAPTER TWO
2.1 NEURODEGENERATION 3
2.1.1 NEURODEGENERATIVE DISEASES AND TYPES 3
2.1.1.1 ALZHEIMER DISEASE 4
2.1.1.2 HUNTINGTON’S DISEASE 7
2.1.1.3 PARKINSON DISEASE 9
2.2 MITOCHONDRIA PYRUVATE CARRIER 12
2.3 THIAZOLIDINEDIONES (TZDs) AND NEURODEGENERATION 14
2.3.1 OLD GENERATION VERSUS NEW GENERATION TZDs 15
CHAPTER THREE
3.1 MECHANISMS OF ATTENUATING NEURODEGENERATION BY
MSDC-1060 18
3.1.1 AUTOPHAGY AUGMENTATION 19
3.1.2 INFLAMMATION REDUCTION 21
3.1.3 EXCITOTOXICITY REDUCTION 23
3.2 FUTURE PERCEPTIVE AND CLINICAL IMPLICATION OF MSDC-1060 25
CHAPTER 4
4.0 CONCLUSION 28
REFERENCES 29
Ogunsola, S. (2019). Inhibition of mitochondria pyruvate carrier- an approach to attenuating neurodegeneration. Afribary. Retrieved from https://afribary.com/works/mitochondria-pyruvate-carrier-inhibition-an-atenuation-to-neurodegeneration
Ogunsola, Samuel "Inhibition of mitochondria pyruvate carrier- an approach to attenuating neurodegeneration" Afribary. Afribary, 01 Feb. 2019, https://afribary.com/works/mitochondria-pyruvate-carrier-inhibition-an-atenuation-to-neurodegeneration. Accessed 04 Oct. 2024.
Ogunsola, Samuel . "Inhibition of mitochondria pyruvate carrier- an approach to attenuating neurodegeneration". Afribary, Afribary, 01 Feb. 2019. Web. 04 Oct. 2024. < https://afribary.com/works/mitochondria-pyruvate-carrier-inhibition-an-atenuation-to-neurodegeneration >.
Ogunsola, Samuel . "Inhibition of mitochondria pyruvate carrier- an approach to attenuating neurodegeneration" Afribary (2019). Accessed October 04, 2024. https://afribary.com/works/mitochondria-pyruvate-carrier-inhibition-an-atenuation-to-neurodegeneration