Effects of White Grub Extracts on Serum Glucose and Lipid Profile of Alloxan Induced Diabetes in Rats

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Diabetes mellitus is a syndrome characterized by chronic hyperglycemia and disturbances of carbohydrate, fat
and protein metabolism associated with an absolute or relative deficiency in insulin secretion or insulin action. To
investigate the effect of white grub extract on alloxan-induced diabetic rats. Diabetes was induced in rats after 18
hours of fasting intraperitoneally by alloxan (80 mg/kg). A total of 40 rats used, were divided into eight groups (G1-
GVIII) of five rats each. GII-GVIII were induced with diabetes. GI served as normal control, GII were administered
only distilled water and GIII were administered the standard anti-diabetic drug (Glibenclamide ‘5 mg’). While GIV
(E2, 100 mg/kg), GV (E3, 200 mg/kg), GVI (E4, 300 mg/kg), GVII (F1, 400 mg/kg) and GVIII (F2, 500 mg/kg) were
respectively administered with fraction of white grub extracts. After fifteen (15) days of oral administration of the
extracts, the animals were sacrificed and the serum was collected for analysis of lipid profile (Total Cholesterol ‘TC’,
Low Density Lipoprotein-Cholesterol ‘LDL-C’, High Density Lipoprotein-Cholesterol ‘HDL-C’, Very Low Density
Lipoprotein ‘VLDL’ and Triglycerides ‘TG’). Significant decrease (P<0.05) in the serum TC, LDL-C, HLDL-C, for
GIV, GV, GVI, GVII, and GVIII and TG, VLDL, for GIV and GVI, and significant increase (P<0.05) in the TG and
VLDL for GIV, GVI, and GVIII levels were observed in diabetic treated groups when compared with diabetic
untreated group (GII), while GVIII show normal HDL-C level which is comparable to normal control group. The
Group (GVIII) also show a Significant increase in TC, TG, VLDL, and LDL-C and a significant decrease in HDL-C
when compared to the GIII treated with the standard drug. Percentage increase and decreased blood glucose (BG)
levels and lipid profile were evaluated for fifteen days of oral administration of the extracts. The Fourier Transform
Infrared (FTIR) analysis of the most active extract shows that the compounds may contain the functional groups like
–OH, Nitro, -COOH, an aromatic ring, and others, while it's Gas chromatography-Mass spectroscopy (GC-MS)
analysis may contain Urea, Fatty acids and carbohydrate among others. This result shows a positive curative effect
of the white grub extracts in the management of Diabetes mellitus (DM) and lipid abnormalities may be associated
with the presence of the compounds.

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APA

Said, S (2019). Effects of White Grub Extracts on Serum Glucose and Lipid Profile of Alloxan Induced Diabetes in Rats. Afribary.com: Retrieved November 27, 2020, from https://afribary.com/works/said-et-al-wg-paper

MLA 8th

Said, Said. "Effects of White Grub Extracts on Serum Glucose and Lipid Profile of Alloxan Induced Diabetes in Rats" Afribary.com. Afribary.com, 15 Aug. 2019, https://afribary.com/works/said-et-al-wg-paper . Accessed 27 Nov. 2020.

MLA7

Said, Said. "Effects of White Grub Extracts on Serum Glucose and Lipid Profile of Alloxan Induced Diabetes in Rats". Afribary.com, Afribary.com, 15 Aug. 2019. Web. 27 Nov. 2020. < https://afribary.com/works/said-et-al-wg-paper >.

Chicago

Said, Said. "Effects of White Grub Extracts on Serum Glucose and Lipid Profile of Alloxan Induced Diabetes in Rats" Afribary.com (2019). Accessed November 27, 2020. https://afribary.com/works/said-et-al-wg-paper