Effects of White Grub Extracts on Serum Glucose and Lipid Profile of Alloxan Induced Diabetes in Rats

Diabetes mellitus is a syndrome characterized by chronic hyperglycemia and disturbances of carbohydrate, fat
and protein metabolism associated with an absolute or relative deficiency in insulin secretion or insulin action. To
investigate the effect of white grub extract on alloxan-induced diabetic rats. Diabetes was induced in rats after 18
hours of fasting intraperitoneally by alloxan (80 mg/kg). A total of 40 rats used, were divided into eight groups (G1-
GVIII) of five rats each. GII-GVIII were induced with diabetes. GI served as normal control, GII were administered
only distilled water and GIII were administered the standard anti-diabetic drug (Glibenclamide ‘5 mg’). While GIV
(E2, 100 mg/kg), GV (E3, 200 mg/kg), GVI (E4, 300 mg/kg), GVII (F1, 400 mg/kg) and GVIII (F2, 500 mg/kg) were
respectively administered with fraction of white grub extracts. After fifteen (15) days of oral administration of the
extracts, the animals were sacrificed and the serum was collected for analysis of lipid profile (Total Cholesterol ‘TC’,
Low Density Lipoprotein-Cholesterol ‘LDL-C’, High Density Lipoprotein-Cholesterol ‘HDL-C’, Very Low Density
Lipoprotein ‘VLDL’ and Triglycerides ‘TG’). Significant decrease (P