Hepatoprotective Potential of Alkaloid Extracts from Vitex doniana and Ficus thonningii Leaves in Alloxan-induced Diabetic Rats
Aim: This study sought to evaluate the hepatoprotective potential of alkaloid extracts from V. doniana and F. thonningii leaves on alloxan-induced diabetic rats. Materials and Methods: Fresh leaves of V. doniana and F. thonningii were obtained from a local market Nkwagu in Abakaliki local government area of Ebonyi State. They were dried and pulverized to fine granules using manual grinder. Crude alkaloid was extracted using standard method. The acute oral toxicity of both plants was determine...
Ameliorative Potential of Bambara Nuts (Vigna subterranea (L.) Verdc) Extract against Acute Ethanol-Induced Oxidative Stress in Wistar Rats
Abstract The aim of this study was to determine the ameliorative potential of Bambara nuts extract against acute ethanol-induced oxidative stress in Wistar rats. Bambara nuts of the Songkhla 1 variety locally sourced in Obinze area of Owerri, Imo State, Nigeria were powdered using a coffee grinder and an extract obtained from a Soxhlet apparatus with methanol as solvent. Twenty-four adult male Wistar rats were acclimatized for seven days and were randomly divided into four groups of six rats ...
Evaluation of Methanolic Extract of Bambara Nut on Renal Indices of Wistar Rats
Background: Bambara nut is a common household food in Nigeria especially among the Igbos ofthe South Eastern part of the country.Aim: This study is aimed at investigating the effect of Bambara nut on renal indices of Wistar rats.Methodology: The Songkhla 1 variety (red seed coat) of Bambara nuts were locally sourced in Obinze area of Owerri, Imo State, Nigeria. The seeds were peeled and ground to a fine powder using a coffee grinder and extracted using soxhlet apparatus and methanol as the so...
Effect of Bambara Nut on Hepatic Biomarkers of Wistar Rats
Aim: This study sought to investigate the effect of Bambara nut on hepatic biomarkers of Wistar rats.Methodology: The Songkhla 1 variety (red seed coat) of Bambara nuts were locally sourced in Obinze area of Owerri, Imo State, Nigeria. The seeds were peeled and ground to a fine powderusing a coffee grinder and extracted using soxhlet apparatus and methanol as the solvent. Twentyfour adult male Wistar rats were acclimatized for seven days during which they were fed ad libitum with standard fe...
Effect of Bambara Nut Consumption on Blood Glucose Level
Aim: This study sought to investigate the effect of Bambara nut consumption on blood glucose level and lipid profile of Wistar rats.Methodology: The Songkhla 1 variety (red seed coat) of Bambara nuts were locally sourced from Obinze area of Owerri, Imo State, Nigeria. The seeds were peeled and ground to a fine powder using a coffee grinder and extracted using soxhlet apparatus and methanol as the solvent. Twenty four adult male Wistar rats were acclimatized for seven days during which the...
Qualitative Determination of Phytochemical Composition of Ethanolic Extract of Xylopia aethiopica Fruit
Aim: The aim of this study is to qualitatively determine the phytochemical compositions of ethanolic extract of Xylopia aethiopica fruit.Methodology: The fruits of Xylopia aethiopica were obtained from new market in Aba, Abia State and were identified and authenticated by Prof. (Mrs) Margaret Bassey of the Department of Botany and Ecological Studies, University of Uyo with the voucher number UU/PH/4e. The plant was deposited in the Herbarium of the Department of Pharmacognosy and Natural Medi...
Hepatotoxic effect of Xylopia aethiopica Fruit in Wistar Rats
Background: Xylopia aethiopica fruit has been reported to possess high medicinal value. Thus, people use it without any regard for its toxicity.Aim: This study is therefore aimed at investigating its toxicity on the liver of Wistar rats.Methodology: The fruits of Xylopia aethiopica were obtained from new market in Aba, Abia State, Nigeria and were authenticated. They were air-dried and extracted using Soxhlet apparatus and ethanol as solvent. The median lethal dose (LD50) of the extract was d...
Hypolipidemic Propensity of Ethanolic Extract of Xylopia
ABSTRACT Aim: This study is aimed at assessing the effect of Xylopia aethiopica fruit on the lipid profile of Wistar rats. Methodology: The fruits of Xylopia aethiopica were obtained from new market in Aba, Abia State, Nigeria and were authenticated. They were air-dried and extracted using Soxhlet apparatus and ethanol as solvent. The median lethal dose (LD50) of the extract was determined using standard met...
Weight Gain Reduction and Hypoglycemic Effects of Xylopi
ABSTRACT Aim: This study is aimed at determining the effect of Xylopia aethiopica fruit on weight gain and blood sugar level of Wistar rats. Methodology: The fruits of Xylopia aethiopica were obtained from new market in Aba, Abia State, Nigeria and were authenticated. They were air-dried and extracted using Soxhlet apparatus and ethanol as solvent. The median lethal dose (LD50) of the extract was determined using standard method. ...
Nephrotoxicity of Ethanol Extract of Xylopia aethiopica
ABSTRACT Background: The use of Xylopia aethiopica fruit in folklore medicine is on the increase without regard to its toxicity. Aim: This study was aimed at examining its toxicity on the kidney of Wistar rats. Methodology: The fruits of Xylopia aethiopica were air-dried and extracted using Soxhlet apparatus and ethanol as solvent. The median lethal dose (LD50) of the extract was determined using standard method....
Garlic Bulb Prevents High Blood Pressure in Egg Yolk induced Hypertensive Rats
The aim of this study is to access the antihypertensivepotential of garlic juice in rats. To achieve this, 30 Wistar ratswere divided into three groups of 10 each. Rats in groups 1 and 2received aspecial prepared egg feed diet (24 egg yolkmixed with 1kg of normal rat diet) while those in group 3 received normalfeed diet and they served as the control group. Animals in group2 were administered 3 mL/100g body weight of undiluted garlicjuice simultaneously with the feeding. The animals were fedo...
Egg Yolk induces High Blood Pressure in Wistar Rats
Hypertension constitutes a major risk factor forseveral cardiovascular diseases such asatherosclerosis, heart failure, renal insufficiency,coronary artery disease and stroke. The risk factorincreases with age in both sexes. According to WHO,about one-third of the world’s population suffersfrom hypertension and the incidence has beenincreasing at a rapid rate due to life stylemodification. This study is aimed at investigating theeffect of egg yolk on blood pressure of Wistar rats. Toachieve ...
Effect of Consumption of Garri Processed by Traditional and Instant Mechanical Methods on Lipid Profile of Wistar Rats
Aim: This study focuses on the effect of consumption of garri processed by traditional and instantmechanical methods on the lipid profile of Wistar rats.Methods: Cassava samples were obtained from the International Institute of Tropical Agriculture(IITA), Ibadan and were processed using traditional and instant mechanical methods. Fifteen adultmale Wistar rats were purchased from the Animal Holding Unit of the Department of Physiology,University of Ibadan, Nigeria with body weight between 100 ...
Air Freshener induced Oxidative Stress and Adveresly affects Immunity
Recently, the use of ‘sunlight’ air freshener in Nigeria is on the increase. Some people use airfreshener in the office, car as well as in their homes, thereby constantly being exposed to it withoutconsideration of its adverse effect on human health. This study is therefore aimed at assessing theeffect of “sunlight” air freshener on oxidative stress biomarkers. Thirty (30) Wistar rats were dividedinto three groups of ten each and kept in different rooms. Rats in group 1 were not expos...
Effect of Common Household Insecticides Used in Nigeria on Rat Male Reproductive Hormones
Background: The use of household insecticides for the eradication of insects especially mosquitoesin Nigeria is increasing. These insecticides are used without consideration of their adverse effect onhuman health.Aim: This study was aimed at accessing the effect of common household insecticides used inNigeria on male reproductive hormones of Wistar rats.Methodology: Thirty male Wistar rats were divided into five groups of six each and kept in differentrooms. Rats in group 1 were exposed to Ra...
