Research Papers/Topics in Pharmacology

A Randomized Trial to Monitor the Efficacy and Effectiveness by QT-NASBA of Artemether-lumefantrine versus Dihydroartemisinin-piperaquine for Treatment and Transmission Control of Uncomplicat

Abstract: Background: Many countries have implemented artemisinin-based combination therapy (ACT) for the first-line treatment of malaria. Although many studies have been performed on efficacy and tolerability of the combination arthemeter-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP), less is known of the effect of these drugs on gametocyte development, which is an important issue in malaria control. Methods and results: In this two-arm randomized controlled trial, 146 children ...

Efficacy of Single-Dose Primaquine With Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis

Abstract: Background. Since the World Health Organization recommended single low-dose (0.25 mg/kg) primaquine (PQ) in combination with artemisinin-based combination therapies (ACTs) in areas of low transmission or artemisinin-resistant Plasmodium falciparum, several single-site studies have been conducted to assess efficacy. Methods. An individual patient meta-analysis to assess gametocytocidal and transmission-blocking efficacy of PQ in combination with different ACTs was conducted. Random ...

Synthesis and Anti-Inflammatory Properties of Aminomethyl Derivatives of 2 Naphthol

ABSTRACT The usefulness of non-steroidal anti-inflammatory agents in the management of rheumatoid diseases cannot be over-emphasized. As this disease is characterized by chronic inflammation, it is usual to test compounds for anti-inflammatory activity in animals and then hope that the active ones should be clinically useful as anti-rheumatic drugs, From the literature, non-steroidal anti-inflammatory agents have covered a wide range of chemical structures aryl acetic, aryl-propionic, arylbu...

Anti Inflammatory Activity of the Fatty Seed Extract of Vitellaria Paradoxa (Sapotaceae)

ABSTRACT  Fatty seed extracts of Vitellaria paradoxa (Sapotaceae), an indigenous plant of West Africa is a popular remedy for arthritis and swellings. This study investigated the knowledge, prevalence and pattern of use of the fatty extract also known as shea butter in clinically diagnosed arthritic patients as well as its effects on acute (topical and systemic) and chronic inflammation in rodents. The knowledge, prevalence and pattern of use were determined using pretested questionnaire in ...

Protective Role of Aqueous Leaf Extract of Vernonia Amygdalina Del. (Asteraceae) and Ocimum Gratissimum Linn (Lamiaceae) in Cyclophosphamide Induced Urotoxicity and Myelosuppression

ABSTRACT  Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. In the present study, the protective potential of Vernonia amygdalina and Ocimum gratissimum aqueous leaf extracts in CP-induced urotoxicity and myelosupression were evaluated using biochemical and histopathological approaches. Sodium -2-macarptoethane sulfonate (MESNA) was used as a...

Evaluation of the Subacute and Delayed Toxicity of Artemether-Lumefantrine Combination in Rats

ABSTRACT  Despite the reported rapid increase in demand for artemisinin and its derivatives, there is little independent collaboration of the toxicity patterns of artemether-lumefantrine combination besides those documented by the manufacturer in its application for approval. It is however, pertinent to conduct an independent evaluation of the subacute and delayed toxicity of artemether-lumefantrine combination (ALC). In this study, rats in groups I-VI were administered varying concentration...

Evaluation of the Immunomodulatory Activities of the Aqueous Extract and the BetaD-Glucan-Rich Polysaccharide Fraction of Pleurotustuberregium(Pleurotaceae)

ABSTRACT Mushroom cuisines are global delicacies and have been used for decades, not only as food, but mostly for the health benefits which are claimed or scientifically proven. The present study explored the immunomodulatory activities of the hot aqueous extract of a local oyster mushroom, Pleurotustuberregium (Fr.) Singer (Pleurotaceae) (PT) and its β–D-Glucan-Rich Polysaccharide fraction (BGP).The effects of the aqueous extract (PT) and the β–D-Glucan-Rich Polysaccharide fraction (B...

Effects of Heavy Metals on the Air Pollution Tolerance Indices ( Apti ) of Five Medicinal Plants Growing Within Quarry Site in Ishi-Agu, Ebonyi State, Nigeria.

ABSTRACT Effects of heavy metals on the Air Pollution Tolerance Indices (APTI) of five medicinal plants growing within quarry site in Ishi-Agu, Ebonyi State, Nigeria were studied. Following laboratory analysis of the leaves of the plants for metal load and four biochemical parameters of APTI computation. The metal load was determined by the Atomic Absorption spectrophotometric method, while the ascorbic acid was determined by the titremetric method, leaf extract pH by the electro-chemical tec...

Antihyperlipidemic and Antioxidant Effects of Phaseolus Vulgaris Linn in Wistar Rats

ABSTRACT In this study, the antihyperlipidemic and antioxidants activities of the extract and fractions of Phaseolus vulgaris L. were evaluated. The crude extract (PVE) of dried pulverized plant material was obtained by maceration in methylene chloride/methanol (1:1) while the solvent fractions were obtained by successive solvent-solvent partition in separating funnel between the crude extract suspended in aqueous medium and solvents of increasing polarity to obtain the n-hexane fraction (PVH...

Antioxidant and Hepatoprotective Studies of Annonasenegalensispers. (Annonaceae) Stem Bark.

Abstract The study was carried out to determine pharmacognostic standards, phytochemical constituents, evaluate the antioxidant and hepatoprotective activities of the extract and fractions of Annona senegalensis Pers. (Annonaceae) by employing both the in vitro and in vivo experimental models. The acute toxicity tests result showed the drug is safe at 5000mg/kg doses. The effect of DPPH free radical scavenging, ABTS radical scavenging, Hydroxyl radical scavenging, Hydrogen peroxide scavenging...

Pharmacological Evaluation and Characterization of the Antiulcer Constituents of Stem Bark Extract of Bridelia Ferruginous Benth (Euphorbiaceous)

ABSTRACT Peptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. The search for an ideal antiulcer drug continues and has also been extended to medicinal plants. Bridelia ferruginea Benth (Euphorbiaceae) is a plant used in traditional medical practice in South West Nigeria. This study was aimed at evaluating the antiulcer activity and mechanisms of the extract of the stem bark and to isolate the bioactive constituents responsible for the antiulcer activity. Metha...

Pharmacological Assessment of Lupinus Arboreus Sims (Fabaceae) Methanol Extract and Three Active Constituents for Antinociceptive and Anti-Inflammatory Effects

ABSTRACT The methanol extract and chemical constituents of Lupinus arboreus leaf were investigated for antinociceptive and anti-inflammatory activities. The study was by experimental design. the extract was partitioned to yield hexane, ethylacetate, and methanol fractions. Phytochemical tests were done on the extract and fractions. Acute toxicity test (LD50) was carried out on crude methanol leaf extract (CME). Extract hexane fraction (HEF), ethylacetate fraction (EAF) and methanol fraction (...

Evaluation of the Immunomodulatory Activities of the Aqueous Extract and the Beta–D-Glucan-Rich Polysaccharide Fraction of Pleurotustuberregium(Pleurotaceae)

ABSTRACT Mushroom cuisines are global delicacies and have been used for decades, not only as food, but mostly for the health benefits which are claimed or scientifically proven. The present study explored the immunomodulatoryactivites of the hot aqueous extract of a local oyster mushroom, Pleurotustuberregium (Fr.) Singer (Pleurotaceae) (PT) and its β–D-Glucan-Rich Polysaccharide fraction (BGP).The effects of the aqueous extract (PT) and the β–D-Glucan-Rich Polysaccharide fraction (BGP)...

2_Ajibo et al analgesic cpds

The Antioxidant Analgesic activity of some Natural plants in Comparison to Acetaminophen 

Pharmacological Effects of Methanol Extract of Garcinia Kola (Heckel) Seed on the Reproductive Profiles of Some Male Experimental Animals

ABSTRACT Garcinia kola is commonly consumed in Nigeria in social ceremonies and for leisure purposes. It is speculated to enhance sexual performance in males. The effects of methanolic extract of Garcinia kola seed on the male reproductive profiles of rats were determined at oral doses of 125, 250 and 500 mg/kg for 20 and 60 days respectively. The animals were administered the extract orally for either 20 or 60 days after which analysis of the parameters were carried out using known standard...


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