ABSTRACT The relationship of antenatal clinic (ANC) attendance and factors that could affect intermittent preventive treatment (IPT) uptake among 339 parturient women was examined. Respondents were enrolled over a period of three months in a secondary healthcare facility within 24 hours of delivery. Demographic details, delivery and antenatal history, insecticide treated net (ITN) use, and history of IPTp-Sulfadoxine-Pyrimethamine (SP) use in the index pregnancy were recorded. Finger and heel...
ABSTRACT Securidaca longepedunculata Fers (Polygalaceae) is commonly used in many parts of Africa for the treatment of rheumatic conditions, fever, headache and various other inflammatory based diseases. The present study was carried out to evaluate the anti-inflammatory and analgesic activity of Securidaca longepedunculata leaf and stem bark methanol extracts using animal model. The anti-inflammatory activity of the methanolic extracts were evaluated using carrageenan induced paw edema in r...
ABSTRACT Background: The use of herbal products has gained popularity especially in developing countries. A number of patients are known to take these herbal products concurrently with conventional drugs. Concomitant use of herbal preparations and conventional drugs may result in herb-drug interactions, often via modulation of drug metabolizing enzymes, in particular, Cytochrome P450 (CYP) enzymes. Swedish bitters is one of such herbal preparations on the market which may be concomitan...
ABSTRACT Background: Chronic kidney disease (CKD) remains one of the complications of Human Immunodeficiency virus (HIV) infection among individuals on antiretroviral medication. This study aimed to determine the prevalence, Knowledge and associated risk factors of CKD among Ogun-state Indigenes with HIV on antiretroviral medications Materials and Methods: This was a hospital-based descriptive cross-sectional study involving 203 previously diagnosed HIV-infected patients on HAART treatmen...
Malaria is a major public health problem in the world especially in Africa, with an estimated two million children and pregnant women worldwide dying of malaria yearly, primarily because of Plasmodium falciparum and its complications. Preliminary phytochemical screening of the methanol leaf extract revealed the presence of triterpenoids, saponins, tannins, terpenoids, flavonoid, cardiac glycoside, carbohydrate and alkaloids. The in vivo antimalarial activity of the crude methanol leaf ...
ABSTRACT: The study evaluated effect of aqueous leaf extracts of C. articulata and M. aethiopicum on serum levels of testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin in male albino rats as well as on organ weights and histological structure of the testis. The phytochemical composition of the extracts was also qualitatively determined. This was an experimental study. Shade dried C. articulata and M. aethiopicum leaves were pounded and crude extracts were...
TABLE OF CONTENTS CONTENTS PAGE TITLE PAGE---------i DECLARATION--------ii CERTIFICATION--------iii DEDICATION--------iv ACKNOWLEDGEMENT-------v TABLE OF CONTENT-------vi LIST OF TABLES--------ix LIST OF FIGURES-------ix ABSTRACT---------x CHAPTER ONE INTRODUCTION AND LITERATURE REVIEW 1.1 TRADITIONAL MEDICINE-------1 1.2 MODERN MEDICINE--------4 1.2.1 The Role of Plants in Drug Development -----4 1.3 DESCRIPTION OF THE STUDY PLANT - -----5 1.3.1 Scientific Classification and Folkloric U...
ABSTRACT Objectives: to explore the anxiolytic activity of ethanolic leaf extract of culcasian scadens in experimental animal models . Methods: The anxiolytic activity was examined by using the elevated plus maze (EPM) and open field test (OFT), hole board test and light and dark box exploration test. Twenty Swiss albino male mice were divided into five groups of four mice each. Group 1 received distilled water and served as negative control; group 2 received 100mg/kg of ECS; group 3 receiv...
Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortality rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmanthera dependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided into two broad groups of twenty five rats each for aspirin and indomethacin models respectively. For each model, twenty five adult rats divided into five groups of four rats each were used for ulcer s...
Adverse drug reactions (ADR) triggered by a drug or its metabolites is an essential aspect of the post-clinical phase in the drug discovery pipeline. The pathophysiology of ADRs has been described in two ways; expected and idiosyncratic. In the current study, we deployed valid computational tools to predict the ability of eight green tea polyphenols to favourably interact with HLA-B*57:01 and mediate idiosyncratic ADRs. First, we deployed molecular docking to understand the free energy profil...
ABSTACT The pharmacological effects of the metanolic root extract of the plant Alafia barteri Oliv. used commonly in West and Central Africa, from Guinea Bissau east to Cameroon and south to Congo, including Nigeria for the treatment of various diseases (including malaria, arthritis, eye infection an inflammation) was evaluated. The analgesic effect of the metanolic root extract of Alafia barteri (100, 200 and 400mg/kg) was evaluated in mice using Acetic acid induced writhing, Formalin induc...
Rauwolfia vomitoria is a natural medicinal herb which has been used over the years for the treatment of hypertension and mental disorders. This is to investigate the inhibitory effect of RAUWOLFIA VOMITORIA aqueous root extract on invitro isolated rabbit intestine precontracted with Acetylcholine. The effect of the root extract was compared with adrenaline.seven healthy adult rabbit bred in the animal house of college of basic medical science delta state university,abrake were alowed to aclim...
ABSTRACT Malaria is an enormous public health problem worldwide and kills one to two million people every year, mostly children residing in Africa . And the aim of this study is to determine the impact of combined treatment with Artesunate and Chloroquine on the white blood cell count of plasmodium berghei infected albino mice. And to compare and observe effect of combined treatment of chloroquine and artesunate on white blood cell count of P. berghei infected albino mice. A total of 15 ...
Cancer being one of the leading causes of death worldwide Many active secretions produced by animals have been employed in the development of new drugs to treat cancer. There is urgent need to search for new drugs from natural products. In recent years, remarkable progress has been made for the treatment of cancer. The major drawback of the current methods of cancer treatment is the therapies after initial treatments. It has led to the increased use of anticancer drug developed from natural s...
ABSTRACT The Sympathetic nervous systems (SNS) is an efferent division of the Autonomic nervous system (ANS) with neurons which anatomically originates in the central nervous system (CNS). It has a short preganglionic neuron which comes from the thoracic and lumbar regions (T1 to L2) (also termed, thoracolumbar outflow) of the spinal cord. The axons of the postganglionic neuron extend from these ganglia to the tissues that they innervate and regulate. In most cases, the preganglion...