ABSTRACT Background: Cognitive dysfunction, presenting as learning and memory impairment, is a common manifestation in many chronic diseases, including depression, epilepsy and Alzheimer’s disease. It could also be present without any known underlying medical condition. Till date, no drug has shown convincing efficacy in improving learning and memory deficits in these conditions although some medicinal plants are demonstrating promising effects. The aim of the study was to investigate the e...
ABSTRACT Background: Diabetic nephropathy (DN), a diabetes-induced nerve damaging effect on the kidney structure and function due to hyperglycaemia is a major microvascular complication. Hyperglycaemia causes uremia, hypercreatininemia, declined glomerular filtration rate, and decreased levels of serum protein and albumin. This condition leads to progressive decline in renal function resulting in renal insufficiency and End-Stage Renal Disease. The prevalence of DN in Africa has increased sig...
ABSTRACT Background: Sepsis is a major cause of death among neonates. In neonates, symptoms of sepsis are often non-specific and diagnosis requires a high index of suspicion. Thus, the role of additional diagnostic markers is important. Amikacin is used as first-line treatment of neonatal sepsis and it is usually co-administered with aminophylline in preterm neonates in Ghana. Amikacin dosing is well established, however, optimal effect requires specific dose titration and maintenance therap...
ABSTRACT The main objective of this study was to compare the hypoglycemic activity of ethylacetate soluble portion of aqueous acetone extract of the root bark (EtOAcfr TARB) and stem (EtOAcfr TASB) back of Treculia africana Decne in diabetic rats and also to characterize the ultraviolent and infrared spectra of an isolated constituent. Oral administration of the EtOAcfr TARB reduced fasting blood glucose level by 28.6% in 144hrs and 15.9% at 240 hrs in alloxan (100 mg/kg) induced rat of five ...
In rural savannah areas of Nigeria, Echics ocellatus (Carpet viper) is responsible for high incidence of snakebite morbidity and mortality. The snakebites are commonly treated with plant extracts in form of traditional medicine. The antivenom activity of Paullinia pinnata Linn and Detarium microcarpum Guill and Perr, popular herbs used in the treatment of Echis ocellatus bites are of great interest and were investigated in vivo and in vitro against the venom (2mg/kg) of Echis carniatus. ...
ABSTRACT Garcinia kola Heckel (Guttiferae) seed, has found use in folkloric medicine of Southern Nigeria for the treatment of toothache and prevention of dental caries. The crude ethanolic extract, chromatographic fractions and isolated constituents of Garcinia kola seed against clinical strains of dental-caries-causing and related microorganisms is being evaluated. Antimicrobial evaluations were done by testing different concentrations of the crude extract, vacuum liquid chromatographic (VL...
ABSTRACT The characteristics of the post-junctional -aarenoceptors in the isolated anococcygeus muscle and vas deferens were compared in spontaneously hypertensive rats (SHR) and normotensive rats (NCR). Responses to CK —adrenoceptor agonists were obtained in the absence and presence of cocaine and of antagonists, Noradrenaline I (NA) and phenylephrine (PE) produced concentration related contrac— tions of the preparations which were antagonised by phentolamine5 prazosin and yohimbine in b...
ABSTRACT Background: Cognitive dysfunction, presenting as learning and memory impairment, is a common manifestation in many chronic diseases, including depression, epilepsy and Alzheimer’s disease. It could also be present without any known underlying medical condition. Till date, no drug has shown convincing efficacy in improving learning and memory deficits in these conditions although some medicinal plants are demonstrating promising effects. The aim of the study was to investigate the e...
ABSTRACT An ethnobotanical survey was conducted among residents of Gboko and Kastina Ala local government areas in Benue state located in the middle belt of Nigeria.
ABSTRACT BACKGROUND: Termitomyces schimperi (TS) is an edible mushroom that is known to possess certain therapeutic properties. Anecdotal report from La Cote d’Ivoire suggests that the mushroom is traditionally used in combination with kaolin, to manage a number of cancers. There is, however, a dearth of information on its antioxidant and anticancer properties with or without kaolin. AIMS: The aims of this study were to determine the antioxidant and cytotoxic potential of aqueous and ethano...
ABSTRACT Background: There is considerable evidence that many patients concurrently take conventional drugs with dietary supplements or herbal products. One such supplement, with an amalgam of extracts, is Cellgevity®. There is, however, a dearth of information on the effect of this supplement on drug metabolizing enzymes, and on the pharmacokinetics of conventional drugs. Aim: To determine the effect of Cellgevity® on the activity of rat liver CYP1A1/2, CYP3A4, CYP2B1/2, CYP2C9 and CYP2D6 ...
ABSTRACT In the course of evaluating the contributions of phytomedicine to possible drug discovery of antimalarial drugs an ethnomedical survey of specialized children traditional clinics was done.
ABSTRACT Adenopus breviflorus is a perennial climber used locally as an anti-convulsant, sedative and pain-killer in West Africa. Several studies have reported gastrointestinal, reproductive and anti-microbial effects of extracts of Adenopus breviflorus, but there is dearth of information on its neurological effect. This study was therefore designed to investigate effect of Ethanol Extract of Adenopus breviflorus (EEAB) on central nervous system in mice. Three hundred gram of air-dried Adeno...
ABSTRACT The characteristics of the post-junctional -adrenoceptors in the isolated anococcygeus muscle and vas deferens were compared in spontaneously hypertensive rats (SHR) and normotensive rats (NCR), Responses to CK —adrenoceptor agonists were obtained in the absence and presence of cocaine and of antagonists, Noradrenaline I (NA) and phenylephrine (PE) produced concentration related contractions of the preparations which were antagonised by phentolamine5 prazosin and yohimbine in both ...
ABSTRACT The relationship of antenatal clinic (ANC) attendance and factors that could affect intermittent preventive treatment (IPT) uptake among 339 parturient women was examined. Respondents were enrolled over a period of three months in a secondary healthcare facility within 24 hours of delivery. Demographic details, delivery and antenatal history, insecticide treated net (ITN) use, and history of IPTp-Sulfadoxine-Pyrimethamine (SP) use in the index pregnancy were recorded. Finger and heel...