The growing number of diabetes coupled with the harsh side effects of some synthetic drugs has led to the increasing search for alternatives
which are relatively cheap with minimal side effects. This study sought to investigate the antidiabetic effect of ethanolic extract of Carica papaya leaves
in alloxan-induced diabetic rats. Thirty adult male albino rats were induced intraperitoneally with alloxan. The rats were grouped into six groups of
five animals per group: Group A was not induced with alloxan, Group B animals were induced but not treated, Group C animals were treated with
glibenclaimide, Group D, E and F animals were treated with 200, 400 and 600 mg/kg body weight of ethanolic leaf extract of C. papaya respectively.
The extracts were administered to the animals orally for 14 days. The animal’s blood sugar levels were assayed using glucometer. The lipid profiles
parameters were assayed using standard methods. The animals administered with 200, 400 and 600 mg/Kg B.W of extract showed significant
decrease (P<0.05) in blood sugar level compared to the untreated animals. The decrease in the blood glucose level of the animals following the
administration of the plant extract suggested that the plant extract possesses antidiabetic effects. The extract of C. papaya produces hypolipidaemic
effect and this is evident as there are significant decrease in plasma total cholesterol, triglycerides, low density lipoprotein-cholesterol and an
increase in plasma high density lipoprotein-cholesterol in the treated groups compared to the untreated group. This implies that C. papaya leaves
could replace glibenclamide in the treatment of diabetes as it has no side effect. The leaves could also be exceedingly helpful in the control of obesity
Augustine, A (2020). Antidiabetic Effect of Ethanolic Extract of Carica papaya Leaves in Alloxan-Induced Diabetic Rats. Afribary.com: Retrieved January 26, 2021, from https://afribary.com/works/antidiabetic-effect-of-ethanolic-extract-of-carica-papaya-leaves-in-alloxan-induced-diabetic-rats
Airaodion, Augustine. "Antidiabetic Effect of Ethanolic Extract of Carica papaya Leaves in Alloxan-Induced Diabetic Rats" Afribary.com. Afribary.com, 26 Jun. 2020, https://afribary.com/works/antidiabetic-effect-of-ethanolic-extract-of-carica-papaya-leaves-in-alloxan-induced-diabetic-rats . Accessed 26 Jan. 2021.
Airaodion, Augustine. "Antidiabetic Effect of Ethanolic Extract of Carica papaya Leaves in Alloxan-Induced Diabetic Rats". Afribary.com, Afribary.com, 26 Jun. 2020. Web. 26 Jan. 2021. < https://afribary.com/works/antidiabetic-effect-of-ethanolic-extract-of-carica-papaya-leaves-in-alloxan-induced-diabetic-rats >.
Airaodion, Augustine. "Antidiabetic Effect of Ethanolic Extract of Carica papaya Leaves in Alloxan-Induced Diabetic Rats" Afribary.com (2020). Accessed January 26, 2021. https://afribary.com/works/antidiabetic-effect-of-ethanolic-extract-of-carica-papaya-leaves-in-alloxan-induced-diabetic-rats