ABSTRACT Pesticides used in agriculture for the control of various pests often leave residues in foodstuffs and these have been shown to pose health hazards. Analysis of pesticide residues in food is one way to determine the level of human exposure to these chemicals and hence their potential human health hazards. Maize (Zea mays L.) and beans (Phaseolus vulgaris L.) samples purchased from different markets in Lagos State were analyzed for residues of organochlorine, organophosphate and carba...
Abstract One of the objectives of the present studies is to investigate the possible interaction potential between ciprofloxacin and some representative antimalarial agents
ABSTRACT White yam starch obtained from the tubers of Dioscorea rotundata Poir was modified by hydroxypropylation and used as a binding agent in a metronidazole tablet formulation and compared with corn starch BP. The quantitative effects of the novel starch binder on the mechanical (tensile strength and friability) and release properties (disintegration and dissolution times) of the metronidazole tablet was analyzed using a full 23 factorial experimental design. The individual and interactio...
sodiuma b s t r a c tFour natural gums, namely albizia, cissus, irvingia and khaya gums have been characterized and evaluatedas polymers for the formulation of microbeads for controlled delivery of diclofenac sodium. The naturalgums were characterized for their material properties using standard methods. Diclofenac microbeadswere prepared by ionotropic gelation using gel blends of the natural gums and sodium alginate at differentratios and zinc chloride solution (10%w/v) as the crosslinking a...
ABSTRACT The use of starches as natural polymers for pharmaceutical applications remains attractive because they are cheap, readily available, biodegradable and capable of modification (Lawal et al., 2007; Yiu et al., 2008; Okunlola et al., 2010). Native starch is a white powder with a bland taste and flavor, and is insoluble in cold water. Due to the sub-optimal properties of native starches, modifications are efficient methods of improving their suitability as excipients for specific pharma...
Austral'! The elhno;;,raphic study was conducted in IWI' communities in Oyo SI;Jle in Southwestern Nigeria. The study sites consisted of it rural .uu! an urban local government area located in the rroplcnl rain forest zone of Nigeria. The study was designed to obtain information on febrile illnesses alld herbal remedies 1'01 treatment with rhc aim of identifying potential antimalarial drugs. The study revealed that fever is a general term for describing illnesses ussociatcd with elevated hody...
Abstract Background: Acetylated starches with degrees of substitution (DS) of > 2 have been found suitable for sustained release applications because of their hydrophobic nature and thermoplasticity. The short half-life and high dosing frequency of repaglinide make it an ideal candidate for sustained release. Objectives: To formulate and evaluate repaglinide microspheres using acetylated starch of the indigenous rice species Oryza glaberrima Steud (Ofada) as polymer. Materials and Methods: Of...
ABSTRACT Controlled release floating metformin hydrochloride microbeads were prepared and optimized using a blend of varying concentrations of freeze-dried pregelatinized Chinese yam starch (Dioscorea oppositifolia L) and sodium alginate. Floating microbeads were prepared by the ionotropic gelation method using 10% w/v calcium chloride as the cross-linking agent and sodium bicarbonate as the gas releasing agent. A full 32 factorial design was used to investigate the influence of two variables...
ABSTRACT Globally, an estimated 3.4 billion people are at risk of malaria, including Nigerians. The current World Health Organization (WHO) Guideline for the treatment of malaria recommends the use of artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. Presently, the available formulations of ACTs are administered through the oral route. Rectal administration, which formed the basis of this work, is an alternative route of administration which overcomes the lim...
ABSTRACT Pregelatinized Chinese yam (Dioscorea oppositifolia) starch has been evaluated as a polymer for the formulation of floating gastroretentive beads for the controlled delivery of metformin hydrochloride. Floating microbeads were prepared by the ionotropic gelation method using a blend of modified Chinese yam starch and sodium alginate at different ratios. Sodium bicarbonate was added as a gas-generating agent. The floating microbeads were characterized by SEM, DSC, FTIR analyses and...
ABSTRACT Nimesulide microspheres were prepared by the quasi-emulsion solvent diffusion method, using acetylated starches of the indigenous Ofada rice (Oryza glaberrima Steud) with degrees of substitution (DS) 1.42 and 2.62. A full 23 factorial experimental design was performed using DS (X1), drug:polymer ratio (X2) and polymer concentration (X3) as independent factors; size, entrapment, swelling and time taken for 80% drug release (t80) were the dependent variables. Contour plots were generat...
ABSTRACT Starch is a naturally occurring polymer found in parts of the plants such as leaves, stems, tubers, and fruits. It is a commonly used excipient in pharmaceutical formulations because of its availability, affordability and inertness. Cyperus esculentus (tiger nut) is widely cultivated in the country especially in the northern part of Nigeria. Until recently, the use of tiger nut had been limited to food products and few pharmaceutical applications. This research is aimed at character...
Abstract In the present study, optimized binary lipid matrices of Tallow fat- Transcutol and Precirol-Transcutol were used to formulate sustained release solid lipid nanoparticles loaded lumefantrine and ciprofloxacin. The homolipid (tallow fat from Bos indicus was extracted and purified following standard methods. Abinitio selection of lipid matrices was done by formulation of binary (3:1) and ternary lipid matrices with different ratios, (1:1:1, 1:2:2 and 2:1:1). Single, binary and ter...
ABSTRACT Microsphere drug delivery systems are used to protect sensitive drugs from enzymatic degradation in the body, for controlled release and tissue targeting of the drug of interest. Starch and products derived from starch modification, are increasingly gaining acceptance in microsphere drug delivery. They are less expensive, non-toxic, readily available, bio-compatible and bio-degradable. The aim of the study was to formulate sustained release pantoprazole microspheres and enteric-coate...
ABSTRACT Propagation of mould and yeast isolates was carried out on a formulated acid-cassava starch medium and commercial potato dextrose agar.